Foreword by Timothy E. Wirth

The Market Street at Apollonia-Arsuf

“…Such structures are generally considered to be shops; they differ fundamentally from regular dwelling structures in towns, which are blank walled outside and have irregularly shaped rooms opening inwards, arranged around an inner courtyard (Petherbridge 1978: 197, 199;Canaan 1933: 40-41, 51-52). In origin, the concept of the market street goes back to the Hellenistic-Roman world (Wirth 1975: 6-46) continue to exist today in most of the large cities of the Middle East (Wirth 1974;1975;Scharabi 1983: 285-96), including in Palestine (fig. 10), which in their architectural elements parallel those disclosed at Apollonia-Arsuf.…”

Targeted Oncogene Therapy Before Surgery in Pediatric Patients With Advanced Invasive Thyroid Cancer at Initial Presentation

“…Within the last 2 years, a number of selective oncogene-specific targeted inhibitors have been investigated in clinical trials for patients with RAI-refractory DTC and advanced MTC. These agents, including rearranged during transfection (RET) inhibitors (pralsetinib/BLU-667 and selpercatinib/LOXO-292), tropomyosin receptor kinase (TRK) inhibitors (larotrectinib), and anaplastic lymphoma kinase (ALK) inhibitors (ensartinib and alectinib), have shown effectiveness in inducing tumor regression with substantially fewer adverse effects compared with MKIs …”

“…Initial data suggest the effectiveness of oncogene-specific targeted therapies in inducing tumor regression of diverse cancers in children and adults, with minimal adverse effects. Therefore, we propose a paradigm shift in the approach to treatment of select pediatric patients who initially present with widely invasive thyroid cancer, in whom neoadjuvant therapy with MKIs or oncogene-specific targeted therapy may be beneficial before a surgical procedure in an effort to reduce surgical morbidity.…”