Foreword by the Guest Editors: Surfaced Enhanced Spectroscopies

Kosower, Edward M.; Markovich, Gil

doi:10.1560/ijc_46_3_i

Cited by 2 publications

(3 citation statements)

References 32 publications

(39 reference statements)

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“…The IR spectra were obtained on an Avatar 370 FT-IR Thermo Nicolet and only noteworthy absorptions are listed. The 1 H NMR (400 MHz) and the 13 C NMR (100 MHz) spectra were recorded on a Bruker Avance, using DMSO-d 6 or CDCl 3 as solvents. Chemical shifts are reported in ppm downfield from TMS as internal standard; coupling constants J are given in Hertz.…”

Section: Scheme 1 Experimentalmentioning

confidence: 99%

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Synthesis of New Multi-Functionalised 1,1′-Carbonylbispyrazole Derivatives

Mohadeszadeh

Saberi

Gholizadeh

2015

Journal of Chemical Research

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Recent research into the synthesis of bis-heterocyclic compounds, which have various practical applications, have attracted the attention of scientists. 1 Bis-pyrazole derivatives have been used as excellent inhibitors of corrosion for many metals and alloys (1, Fig. 1). [2][3][4][5] They are also used as efficient ligands in palladium-catalysed C-O and C-N cross-coupling reactions. [6][7][8][9] The bispyrazole derivatives have coordination properties to metals and are useful as catalysts, 10 for example, heteroscorpionate [RR'C(pz) 2 ] ligands derived from bis(pyrazol-1-yl)methane (2, Fig. 1). 11 The high fluorescence quantum yield of pyrazoline rings add to their wide application in selective recognition of metal ions (3, Fig. 1). 12 Bis-pyrazoles have been used in the treatment of Alzheimer's disease, brain ischaemia, heart diseases, gastrointestinal diseases, cancer, ageing and inflammation. [13][14][15][16] These compounds are also antibacterial and antifungal agents (4, Fig. 1). 17 In addition, palladium and platinum complexes of 5,5'-dimethyl-3,3'-bipyrazole and some poly substituted 1,1'-carbonylbispyrazoles have been reported as potential anti-tumour agents (5, Fig. 1). 18,19 Recently, we have investigated a new versatile route for the synthesis of 1,1'-carbonylbispyrazole derivatives 20 . In an extension of this work, we are undertaking related studies employing bispyrazole derivatives derived from pyrazole carbohydrazides. We now consider the nature of some nucleophiles and the properties of substituted methylene malonitriles which react through Michael addition-cyclisation with the subsequent construction of bis-heterocyclic compounds. Results and discussionEthyl hydrazinecarboxylate 6 reacted with substituted methylene malonitriles 7a-c in absolute ethanol to give ethyl 5-amino-4-cyano-1H-pyrazole-1-carboxylate 8a and ethyl 5-amino-4-cyano-3-methyl-1H-pyrazole-1-carboxylate 8b which have been reported previously, 20 and ethyl 5-amino-4-cyano-3-(methylthio)-1H-pyrazole-1-carboxylate 8c. They were prepared in 80-85% yield, respectively (Scheme 1). The formation of compound 8a-c was confirmed by the presence of the C=O band around 1771 cm -1 in the IR spectrum. The 1

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Section: Scheme 1 Experimentalmentioning

confidence: 99%

“…12 Bis-pyrazoles have been used in the treatment of Alzheimer's disease, brain ischaemia, heart diseases, gastrointestinal diseases, cancer, ageing and inflammation. [13][14][15][16] These compounds are also antibacterial and antifungal agents (4, Fig. 1).…”

mentioning

confidence: 99%

Synthesis of New Multi-Functionalised 1,1′-Carbonylbispyrazole Derivatives

Mohadeszadeh

Saberi

Gholizadeh

2015

Journal of Chemical Research

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“…These changes allow us to exploit the control of sample size and distribution that is an inherent advantage of the smooth AgX element. Historically, SEIRA experiments have been carried out on rough metal surfaces such as silver or gold,4 but as we have noted elsewhere2b, 3, 5 the actual surface consists of a metal oxide or halide for which sample quantitation is not easy. It is easier on more uniform surfaces as shown by an ATR–FTIR study of functionalized sensor chips on a diamond element using averages of 120 scans 6…”

Section: Introductionmentioning

confidence: 99%

Molecule‐Enhanced Surface‐Enhanced Infrared Absorption Spectroscopy (MOSEIRA)

2007

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Surface-enhanced infrared absorption spectroscopy (SEIRA) of methanol, ethanol, 1-propanol, and 2-propanol in thin films on planar silver halide (AgX) fibers under slow N(2) flow using 1 sec scans reveals structure in absorbance-time plots. The absorption intensities show extra enhancements (3x) in the absorbance (O--H stretch) ascribed to oligomers present at the AgX surface (molecule enhanced, thus MOSEIRA). This is above those due to amplification (40x, 20 reflections) and enhancement (30x, image dipoles or surface phonon polaritons). In the case of ethanol an excellent initial pentamer spectrum evolves over 8-10 min to a mixture of pentamer, tetramer, and trimer spectra that within another minute forms small oligomers and monomers. We use a new type of cell for infrared spectroscopy containing an AgX planar fiber. The optical configuration leads to a vicinal region at the surface defined by evanescent waves. Within this region are surface-induced organized species such as ethanol oligomers. The planar AgX fiber supports 20 reflections and transmits light over a wide visible-infrared wavelength range. Short scan times permit the study of volatile substrates or solvents, including the effects of solvent polarity.

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Foreword by the Guest Editors: Surfaced Enhanced Spectroscopies

Cited by 2 publications

References 32 publications

Synthesis of New Multi-Functionalised 1,1′-Carbonylbispyrazole Derivatives

Synthesis of New Multi-Functionalised 1,1′-Carbonylbispyrazole Derivatives

Molecule‐Enhanced Surface‐Enhanced Infrared Absorption Spectroscopy (MOSEIRA)

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