Forensic potential of comprehensive two-dimensional gas chromatography

Sampat, Andjoe A. S.; Lopatka, Martin; Sjerps, Marjan; Vivó-Truyols, Gabriel; Schoenmakers, Peter J.; Asten, Arian C. van

doi:10.1016/j.trac.2015.10.011

Cited by 55 publications

(22 citation statements)

References 98 publications

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“…While established laboratory-based methods for drug investigation (e.g., hyphenated mass spectrometric (MS), spectroscopy, etc.) are known for their accuracy, broad applicability, and court admissibility [8,11,12], throughput is hindered by the required preparative steps and overall duty cycle. Ambient MS techniques [13,14], which increase sample throughput by forgoing extensive sample preparations, have shown proficiency in forensic chemical analysis [15][16][17], with recent reports involving the analysis of biofluids [18,19], explosives [20], adulterated foodstuffs [21], mind-altering plant-based evidence [22], and simultaneous molecular/elemental composition [23].…”

Section: A Review Of the 2009 Census For Publicly Funded Forensicmentioning

confidence: 99%

Analytical Validation of a Portable Mass Spectrometer Featuring Interchangeable, Ambient Ionization Sources for High Throughput Forensic Evidence Screening

Lawton

Traub

Fatigante

et al. 2016

J. Am. Soc. Mass Spectrom.

103

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Abstract. Forensic evidentiary backlogs are indicative of the growing need for costeffective, high-throughput instrumental methods. One such emerging technology that shows high promise in meeting this demand while also allowing on-site forensic investigation is portable mass spectrometric (MS) instrumentation, particularly that which enables the coupling to ambient ionization techniques. While the benefits of rapid, on-site screening of contraband can be anticipated, the inherent legal implications of field-collected data necessitates that the analytical performance of technology employed be commensurate with accepted techniques. To this end, comprehensive analytical validation studies are required before broad incorporation by forensic practitioners can be considered, and are the focus of this work. Pertinent performance characteristics such as throughput, selectivity, accuracy/precision, method robustness, and ruggedness have been investigated. Reliability in the form of false positive/negative response rates is also assessed, examining the effect of variables such as user training and experience level. To provide flexibility toward broad chemical evidence analysis, a suite of rapidly-interchangeable ion sources has been developed and characterized through the analysis of common illicit chemicals and emerging threats like substituted phenethylamines.

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Section: A Review Of the 2009 Census For Publicly Funded Forensicmentioning

confidence: 99%

Analytical Validation of a Portable Mass Spectrometer Featuring Interchangeable, Ambient Ionization Sources for High Throughput Forensic Evidence Screening

Lawton

Traub

Fatigante

et al. 2016

J. Am. Soc. Mass Spectrom.

103

View full text Add to dashboard Cite

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“…In this way, the goal of separate detection is realized. (3)(4)(5) Despite having an excellent capability to detect odorants, GC is not an olfactory sensor. In addition, owing to its high price and rather high demand for skilled experimental operators, GC is mainly used in assessments of complicated mixtures.…”

Section: Gc and Gc-msmentioning

confidence: 99%

Recent Advances in Olfactory Receptor (OR) Biosensors and Cell Signaling Cascade Amplification Systems

2018

Sensors and Materials

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There are a variety of methods to detect odorant molecules, including gas chromatography (GC) and its related coupled techniques, electronic noses, and olfactory receptor (OR)-based biosensors. Nevertheless, studies in which cell and cell signaling amplifier systems were directly utilizied to detect odors are very few. In this review, we aim to provide some references and suggestions for researchers in related fields by summarizing OR sensors and olfactory cell signaling cascade amplifier systems. In this paper, we summarize the detection methods for odorants, introduce the research and progress on OR sensors, and present a proposal of utilizing cell or tissue signaling cascade amplifier systems to amplify electrochemical signals and the use of the G protein signaling cascade amplifier system to prepare electrochemical biosensors. In recent years, the detection technology of electrochemical sensors has matured. Meanwhile, olfactory sensation within organisms basically transfer nerve signals or metabolic endocrine signals in the form of electrochemical signals. Therefore, ORs combined with cell signaling cascade amplifier systems, as well as electrochemical sensors of signal cascade amplifier systems, have incredible prospects for development and application. The proposal of OR electrochemical biosensors and their cell signaling cascade amplifier systems, provides a new idea and a quantitative method for the detection and assessment of odorants and their physiologic processes in the nervous system.

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“…For more thorough information, a series of reviews can be consulted (Adahchour et al, 2006a(Adahchour et al, ,b,c, 2008Tranchida et al, 2004Tranchida et al, , 2007bTranchida et al, , 2015Tranchida et al, , 2016Cortes et al, 2009;Nizio et al, 2012;Cordero et al, 2015;Sampat et al, 2016). The focus of this chapter will be devoted to the penetration of GC Â GC into the lipid analysis field.…”

Section: Applicationsmentioning

confidence: 99%