Forensic parameters and admixture in seven geographical regions of the Guerrero state (South, Mexico) based on STRs of the Globalfiler<sup>®</sup>kit

Aguilar-Velázquez, José Alonso; Locia-Aguilar, Gorge; López-Saucedo, Briselda; Deheza-Bautista, S.; Favela-Mendoza, Alma Faviola; Rangel-Villalobos, Héctor

doi:10.1080/03014460.2019.1568548

Cited by 7 publications

(4 citation statements)

References 24 publications

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“…In this study, despite the small sample sizes and reduced number of markers, we previously confirmed that the LOCPRIOR model in the Structure software offers acceptable admixture estimates in Mexican populations (Aguilar‐Velázquez et al, 2019; Falush et al, 2003; Pritchard et al, 2000). For this study, we considered that the African and European references were sufficient because their ancestries were individually represented in principal clusters in the structure plot and, as expected, they were observed in all the American populations (Figure 3).…”

Section: Discussionsupporting

confidence: 74%

“…Previously, this separation was done with genome‐wide SNPs (Moreno‐Estrada et al, 2014), but it was not possible with the same set of autosomal STRs employed herein (Rangel‐Villalobos et al, 2016). Consequently, our admixture results in Mayas and those recently reported in Mexican Mestizos from Guerrero (Aguilar‐Velázquez et al, 2019) allow us to recommend the use of these parameters in the Structure software, particularly when a limited number of population samples and STRs are available for the anthropological analysis.…”

Section: Discussionsupporting

confidence: 64%

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Genetic diversity, structure, and admixture in Mayans from Guatemala and Mexico based on 15 short tandem repeats

Aguilar-Velázquez

Stephenson-Ojea

García-King

et al. 2021

American J Phys Anthropol

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Objective To analyze the genetic origin, relationships, structure, and admixture in Mayan Native American groups from Guatemala and Mexico based on 15 autosomal short tandem repeats (STRs) loci commonly used in human identification (HID). Methods We genotyped 513 unrelated Mayan samples from Guatemala based on 15 STR loci (AmpFlSTR® Identifiler kit). Moreover, we included 4408 genotypes previously reported, as following: Mayas from Guatemala and Mexico (n = 1666) and from Latin American, European, and African (n = 2742) populations. Forensic parameters, genetic distances, admixture, and population structure were assessed. Results Forensic parameters of the 15 STRs in different Mayan groups from Guatemala were reported. Low (Fst = 0.78%; p = 0.000) and non‐significant differentiation (Fst = 1.8%; p = 0.108) were observed in Mayas from Guatemala and Mexico, respectively. The relative homogeneity observed among Mayan groups supported theories of extensive pre‐Columbian gene flow and trade throughout the Mayan Empire. The distribution of the three Native American ancestries among these Mayan groups did not support the presumable Guatemalan origin of Tojolabal and Lacandon people (South, Mexico). The nonsignificant differentiation between Ladinos and Mayas suggests a relative panmixia in Guatemala. Mestizos from southeastern Mexico and Guatemala constitute a core of Native American ancestry in Latin America related to the Mayan Empire in Central America. Conclusions The higher European admixture and homogeneity in Mexican Mayas of the Yucatan Peninsula suggest more intensive post‐Columbian gene flow in this region than in Guatemalan Mayas.

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Section: Discussionsupporting

confidence: 74%

Section: Discussionsupporting

confidence: 64%

Genetic diversity, structure, and admixture in Mayans from Guatemala and Mexico based on 15 short tandem repeats

Aguilar-Velázquez

Stephenson-Ojea

García-King

et al. 2021

American J Phys Anthropol

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“…For this purpose, STR population databases that included Mexican Native Americans 16 , as well as Europeans and Africans from the USA, were employed as ancestral references 17 . The structure parameters employed herein offered consistent admixture estimates regarding those based on AIMs and genome-wide SNPs, as previously demonstrated in Mexican populations 18 .…”

Section: Methodssupporting

confidence: 74%

Predicting Pathogenicity of CDH1 Gene Variants in Patients with Early-onset Diffuse Gastric Cancer from Western Mexico

García-Ruvalcaba¹,

Rizo-de-la-Torre²,

Magaña-Torres³

et al. 2021

RIC

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Background: Early-onset diffuse gastric cancer (EODGC) occurs at or before 50 years of age. Pathogenic mutations and germline deletions in the CDH1 gene (E-cadherin) are well-documented genetic factors associated with the causes of EODGC. Objective: The objective of the study was to study CDH1 germline variants and their potential functional impact in patients with EODGC in a Mexican population. Methods: We studied seven EODGC patients from a biomedical research center in western Mexico. Variants were identified by Sanger sequencing and multiplex ligation-dependent probe amplification. The DeepSEA and SNPClinic v.1.0 software and the Ensembl (1000 Genomes Project, 1kGP) and ClinVar databases were used to predict functional single-nucleotide polymorphisms (SNPs). The genetic admixture of the Mexican patients was corroborated by 22 short tandem repeat loci genotyping and structure analysis. Results: We found 12 germline CDH1 variants in all EODGC patients, and all of them are considered as polymorphisms: rs34561447, rs5030625, rs16260, rs1330727101, rs28372783, rs942269593, rs3743674, rs1801552, rs34939176, rs33964119, rs3556654, and rs1801026. The prediction of regulatory SNPs in the promoter suggests a role for a retrovirus in EODGC that induces the transcription of interferon-related genes through toll-like receptor-interferon response factor 3 signaling, as three SNPs in the CDH1 promoter alter three binding sites for this transcription factor. In addition, SNPs rs28372783 and rs1801026 could alter upstream stimulatory factors 1 (USF1)/USF2-mediated telomerase-dependent lymphocyte activation in EODGC. Other interesting result is a CTCF-dependent shorter CDH1 isoform lacking exon 14, probably due to exon-skipping mediated by rs33964119. Conclusions: Classical pathogenic germline mutations in the CDH1 gene were not found in these 7 EODGC patients. However, the in silico approaches revealed the possible involvement of a retrovirus and a shorter E-cadherin isoform in EODGC. Nevertheless, further in vitro and in vivo assays are needed to confirm these predictions. (REV INVEST CLIN. [AHEAD OF PRINT])

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“…Notably, the Colima Consensus reported a low BC mortality rate in spite of a high poverty proportion (38.7% moderate poverty and 26.9% extreme poverty) 3,11 . Guerrero state is characterized by a predominantly native American (70.9%) and Afro-descendant (3.2%) genetic makeup, particularly in the coastal regions of Acapulco and Costa Chica, which have significant public health implications 4,12,13 . This study aims to describe the clinical, pathological, and epidemiological characteristics of BC patients in Guerrero and compare them with existing reports on the Mexican population.…”

Section: Introductionmentioning

confidence: 99%

Breast cancer survival in Guerrero: oncologic care and geographic disparities in Mexico

Ocampo-Bárcenas,

De Ita,

Meneses-Morales

et al. 2024

GAMO

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Background: Breast cancer (BC) represents a public health concern among women. Despite the incidence and disparities in economic status, the state of Guerrero in Mexico demonstrates a lower BC mortality rate. Objective: This study investigates the epidemiological characteristics, treatment modalities, and survival outcomes of BC patients in Guerrero, and compares these findings with national data. Method: A retrospective cohort of 923 BC patients treated at the Instituto Estatal de Cancerología Dr. Arturo Beltrán Ortega, from 2010 to 2018 was analyzed. To determine the prognostic factors affecting survival, we employed overall survival analysis and the Cox proportional hazards model. Results: The 5-year survival rate was of 73% . BC patients ≤ 40 years exhibited lower survival rates and a 1.5-fold higher risk of mortality. When comparing the triple-negative subtype to HER2-positive tumors, no significant differences in reducing the risk of death were observed. Conclusion: Despite a higher prevalence of aggressive molecular subtypes in Guerrero, patients share clinical and epidemiological features with their counterparts in other Mexican regions.

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Forensic parameters and admixture in seven geographical regions of the Guerrero state (South, Mexico) based on STRs of the Globalfiler^®kit

Cited by 7 publications

References 24 publications

Genetic diversity, structure, and admixture in Mayans from Guatemala and Mexico based on 15 short tandem repeats

Genetic diversity, structure, and admixture in Mayans from Guatemala and Mexico based on 15 short tandem repeats

Predicting Pathogenicity of CDH1 Gene Variants in Patients with Early-onset Diffuse Gastric Cancer from Western Mexico

Breast cancer survival in Guerrero: oncologic care and geographic disparities in Mexico

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Forensic parameters and admixture in seven geographical regions of the Guerrero state (South, Mexico) based on STRs of the Globalfiler®kit

Cited by 7 publications

References 24 publications

Genetic diversity, structure, and admixture in Mayans from Guatemala and Mexico based on 15 short tandem repeats

Genetic diversity, structure, and admixture in Mayans from Guatemala and Mexico based on 15 short tandem repeats

Predicting Pathogenicity of CDH1 Gene Variants in Patients with Early-onset Diffuse Gastric Cancer from Western Mexico

Breast cancer survival in Guerrero: oncologic care and geographic disparities in Mexico

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Forensic parameters and admixture in seven geographical regions of the Guerrero state (South, Mexico) based on STRs of the Globalfiler^®kit