Forensic, Metabolic, and Autoradiographic Studies of Δ8-and Δ9-Tetrahydrocannabinol

Just, Wilhelm W.; Erdmann, Georg; Werner, G.; Wiechmann, Manfred; Thel, S.

doi:10.1007/978-3-642-51624-5_11

Marihuana 1976

DOI: 10.1007/978-3-642-51624-5_11

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Forensic, Metabolic, and Autoradiographic Studies of Δ8-and Δ9-Tetrahydrocannabinol

Wilhelm W. Just¹,

Georg Erdmann²,

G. Werner³

et al.

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1979

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“…In addition, A9-THC has been reported to retard the proliferation of tumor cells in vivo (16) and in vitro (18). Because A9-THC accumulates in the central nervous system (13) and N. fowleri invades the brain (8), the cannabinoids merit examination as potential drugs for the treatment of primary amoebic meningoencephalitis. The growth of Naegleria fowleri was retarded by 5 and 10 jig of A"-THC per ml and was markedly inhibited by 20 jig of A"-THC per ml (Fig.…”

mentioning

confidence: 99%

Susceptibility of Naegleria fowleri to delta 9-tetrahydrocannabinol

Pringle¹,

Bradley²,

Harris³

1979

Antimicrob Agents Chemother

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Growth of the pathogenic amoeboflagellate Naegleria fowleri is inhibited by delta 9-tetrahydrocannabinol (delta 9-THC). delta 9-THC is amoebostatic at 5 to 50 micrograms/ml. delta 9-THC prevents enflagellation and encystment, but does not impair amoeboid movement. Calf serum at 10 and 20% (vol/vol) reduces the antiamoeba activity of delta 9-THC. Only 1-methoxy delta 8-tetrahydrocannabinol, of 17 cannabinoids tested, failed to inhibit growth of N. fowleri. Antinaeglerial activity was not markedly altered by opening the pyran ring, by converting the cyclohexyl ring to an aromatic ring, or by reversing the hydroxyl and pentyl groups on the benzene ring. delta 9-THC prevented the cytopathic effect of N. fowleri on African green monkey (Vero) cells and human epithelioma (HEp-2) cells in culture. delta 9-THC afforded modest protection to mice infected with N. fowleri.

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mentioning

confidence: 99%

Susceptibility of Naegleria fowleri to delta 9-tetrahydrocannabinol

Pringle¹,

Bradley²,

Harris³

1979

Antimicrob Agents Chemother

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Forensic, Metabolic, and Autoradiographic Studies of Δ8-and Δ9-Tetrahydrocannabinol

Cited by 1 publication

References 22 publications

Susceptibility of Naegleria fowleri to delta 9-tetrahydrocannabinol

Susceptibility of Naegleria fowleri to delta 9-tetrahydrocannabinol

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