Forensic applications of mass spectrometry

Yinon, Jehuda

doi:10.1002/mas.1280100303

Cited by 36 publications

(18 citation statements)

References 77 publications

(1 reference statement)

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“…34,68 Em 2008, Perret e colaboradores 34 confirmaram a presença de resíduos orgânicos de estabilizantes e explosivos (trinitrotolueno (TNT), nitroglicerina (NG), tetranitrato de pentaeritritol (PETN), ciclotrimetilenotrinitramina (RDX), difenilamina (DPA) e etilcentralina (EC)) usando LC/ MS-MS (liquid chromatography/tandem mass spectrometry). Baixos limites de detecção foram obtidos (ng L -1 ).…”

Section: Eletroforese Capilar (Ce) E Cromatografia Líquida (Lc)unclassified

Química forense: perspectivas sobre novos métodos analíticos aplicados à documentoscopia, balística e drogas de abuso

Romão¹,

Schwab²,

Bueno³

et al. 2011

Quím. Nova

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Section: Eletroforese Capilar (Ce) E Cromatografia Líquida (Lc)unclassified

Química forense: perspectivas sobre novos métodos analíticos aplicados à documentoscopia, balística e drogas de abuso

Romão¹,

Schwab²,

Bueno³

et al. 2011

Quím. Nova

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“…1), when the alkaloid was reacted with trimethylchlorosilane (TMCS) in the presence of tetramethylethylenediamine. Therefore, another subject of the present work is to investigate the reactivity of thebaine for TMS derivatization under the experimental conditions routinely used in the GC-MS analysis of opiate drugs [19][20][21][22], and whether the results obtained can be extended to the urinalysis of the alkaloid in specifi c opiate drug-use marking.…”

Section: Introductionmentioning

confidence: 99%

GC-MS detection and characterization of thebaine as a urinary marker of opium use

et al. 2007

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“…Currently, research efforts are under way to combine IMS with realtime data processing using neural network techniques. (157) …”

Section: Ion Mobility Spectrometrymentioning

confidence: 99%

“…(1,2,157) A review of the extensive MS literature on detection of explosives is beyond the scope of this article. We will instead restrict ourselves to laser-and optical-based ionization techniques that have been combined with MS detection, specifically resonance-enhanced multiphoton ionization (REMPI) spectrometry, (132,145,158 -160) which is sometimes also referred to as resonant ionization mass spectrometry (RIMS).…”

Section: Resonance-enhanced Multiphoton Ionization Spectroscopymentioning

confidence: 99%

Laser‐ and Optical‐Based Techniques for the Detection of ExplosivesUpdate based on the original article by David L. Monts, Jagdish P. Singh and Gary M. Boudreaux,Encyclopedia of Analytical Chemistry, © 2000, John Wiley & Sons, Ltd

Hummel

Dubroca

2013

Encyclopedia of Analytical Chemistry

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A wide variety of optical‐ and laser‐based techniques have been and are currently being investigated as means of identifying and characterizing explosive materials. These efforts are hampered by the very low volatility of explosive compounds at room temperature and their tendency to ignite at higher temperatures where their vapor pressures are beginning to reach a regime where the species can be readily detected. Traditional, condensed‐phase absorption spectroscopy (both infrared (IR) and ultraviolet/ visible (UV/VIS)) requires larger samples than are frequently available and, although useful as confirmatory techniques, do not provide signatures that enable unique identification of species. The choice of nontraditional techniques for analysis of explosive materials is dependent upon the amount of sample available, the sample matrix, and sample‐imposed constraints upon the measurement. Raman spectroscopy can identify and quantify condensed phase explosive materials, but the detection limit depends upon substrate, excitation wavelength, and illumination area: limits of detection (LODs) vary from 0.05 ng for 2,4,6‐trinitrotoluene (TNT) on glass to 10 µg for nitroglycerin (NG) on silica gel. The other detection techniques considered require volatilization of either the explosive compound itself or more often of characteristic decomposition products, such as NO, NO 2 , or N 2 O. Using IR irradiation, researchers have demonstrated that photoacoustic spectroscopy (PAS) has detection limits ranging from 0.55 ppb (parts per billion) for vapor‐phase NG with 9 mm excitation to 220 ppm (parts per million) for vaporphase 2,4‐dinitrotoluene (DNT) with 6‐µm excitation. IR laser differential absorption detection of dissociation products NO, NO 2 , and/or N 2 O can achieve detection limits of a few picograms. Laser‐induced fluorescence (LIF) detection of the photofragments (typically NO) of explosive compounds yields detection limits in the tens to hundreds of ppb (by weight) range. Low LODs can be achieved using ion detection techniques: resonance‐enhanced multiphoton ionization (REMPI) spectrometry is capable of LODs for detecting vapor‐phase explosives compounds in the hundredths to tens of ppb range; ion mobility spectrometry (IMS) has vapor‐phase detection limits for common explosive compounds of typically 200 pg, but for some species can be significantly lower: for example, 1 pg for TNT.

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Forensic applications of mass spectrometry

Cited by 36 publications

References 77 publications

Química forense: perspectivas sobre novos métodos analíticos aplicados à documentoscopia, balística e drogas de abuso

Química forense: perspectivas sobre novos métodos analíticos aplicados à documentoscopia, balística e drogas de abuso

GC-MS detection and characterization of thebaine as a urinary marker of opium use

Laser‐ and Optical‐Based Techniques for the Detection of ExplosivesUpdate based on the original article by David L. Monts, Jagdish P. Singh and Gary M. Boudreaux,Encyclopedia of Analytical Chemistry, © 2000, John Wiley & Sons, Ltd

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