Foreign-Body Reaction Against Intraocular Lenses

Sievers, H.; Domarus, D. von

doi:10.1016/0002-9394(84)90507-5

Cited by 79 publications

(12 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…This is in correspondence with the findings of Sievers and von Domarus [1984], Lenses 4 and 5 (table IX, on which endo thelial cells were found, were both removed because of corneal complications. On 1 of the lOLs.…”

Section: Discussionsupporting

confidence: 91%

“…1). The cells with the fine cytoplasmic processes were identical to the cells described by Sievers and von Domarus [1984] as either macrophages or epitheloid cells. The cells with the microvilli could not be named prop erly.…”

Section: Resultssupporting

confidence: 60%

“…6). The membrane fragments are supposed to be parts of the capsule which was described by Wolter [1982a, b] and by Sievers and von Domarus [1984], Wolter [1982a, b] specu lated that this membrane may sequester the IOL in the course of a foreign body reaction. The reason why only fragments could be found might be the destruction of this cap sule during surgery or during preparation for scanning electron microscopy.…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Cytology of Human Intraocular Lenses

et al. 1986

View full text Add to dashboard Cite

Scanning electron microscopy of 9 intraocular lenses, removed from patients mainly because of corneal problems, revealed the presence of different types of adhering elements. Independent of clinically significant symptoms of infection, macrophages and/or epitheloid cells and/or granulocytes were observed. On their anterior surface, 3 lenses showed flat cells or cellular remains which are supposed to represent corneal epithelial cells. Membrane fragments were found on 3 other lenses. Most of the polymethylmethacrylate optics of the lenses showed some deformation and/or cracking and to evaluate them some additional studies with new intraocular lenses were performed. High pressure during the preparation procedure for scanning electron microscopy was found to be the cause.

show abstract

Section: Discussionsupporting

confidence: 91%

Section: Resultssupporting

confidence: 60%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Cytology of Human Intraocular Lenses

et al. 1986

View full text Add to dashboard Cite

show abstract

“…In this regard, PMMA IOLs have shown the earliest and highest peak of numbers of mononuclear ( fi g. of Hydroview IOLs (hydrogel). However, some reports [30,31] demonstrated the IOL haptics to be a focus of marked foreign-body response as a result of the proximity to uveal tissue. BAB damage has a role in the mononuclear macrophage reaction in the immediate postimplantation intervals [19] .…”

Section: Discussionmentioning

confidence: 99%

Biological Compatibility of Polymethyl Methacrylate, Hydrophilic Acrylic and Hydrophobic Acrylic Intraocular Lenses

Barbour¹,

Saika²,

Miyamoto³

et al. 2005

Ophthalmic Res

View full text Add to dashboard Cite

Purpose: Extensive clinical investigations of the biocompatibility of different intraocular lenses (IOLs) have been made in an effort to optimize the outcome of modern cataract surgery. The aim of this study was to add animal eye experimental implantation data regarding cellular reaction on the anterior surface of IOLs. Methods: Thirteen adult albino rabbits had phacoemulsification/aspiration of the crystalline lens followed by implantation of a posterior chamber IOL in each eye. Three types of IOLs were studied: Hydroview^® (Bausch & Lomb; n = 7), Acrysof^® (Alcon, USA; n = 7), and polymethyl methacrylate (PMMA; HOYA, Japan; n = 7). The animals were killed by intravenous pentobarbital 1, 4, or 8 weeks later. The IOLs were explanted and stained with hematoxylin and eosin, and observed under a light microscope. The shape of mouse ascites-induced macrophages on the anterior surface of the three different IOL types (Hydroview, PMMA, and Acrysof) was studied after 24 h of oven culture. Results: Hydrophilic acrylic IOLs showed the highest affinity for lens epithelial cell (LEC) outgrowth, and the lowest and slowest maturation rate reaction of macrophages. PMMA IOLs showed the lowest affinity for LEC outgrowth, and the highest reaction of macrophages. Hydrophobic acrylic IOLs showed intermediate results both regarding LECs and macrophages. Conclusions: Results suggest that IOL biomaterial properties are the key factor that influences the quantity of monocytes/macrophages as well as the process of their maturation/senescence. LEC outgrowth is influenced both by the biomaterial of IOLs and by the monocyte/macrophage reaction.

show abstract

“…[6][7][8][9] This leads to cellular adhesion on the anterior surface of the implant and proliferation of lens epithelial cells resulting in posterior capsule opacification and anterior capsule phimosis. 10 Not only will these responses be heightened in eyes prone to intraocular inflammation, the clarity of the optic will also be jeopardised.…”

Section: Introductionmentioning

confidence: 99%

Brown deposits in the optic of foldable intraocular lenses in patients with uveitis

Manuchehri

Mohamed

Cheung

et al. 2004

Eye

View full text Add to dashboard Cite

Purpose To report a new finding of brown deposits scattered in the substance of the optic of foldable intraocular lenses (IOL) following phakoemulsification in patients with uveitis. Methods Consecutive uveitis patients (54 patients, 71 eyes) who had undergone phakoemulsification with a foldable posterior chamber IOL between March 1996 and November 2000 were studied. A variety of biomaterials from seven different manufacturers had been implanted. One masked observer using slit-lamp biomicroscopy assessed deposits in the substance of the optic of the IOL. Results Brown deposits were detected in the substance of the optic of 25/71 (35%) IOLs with 18/22 (82%) of AcrySof MA60BM IOLs being affected. Using logistic regression analysis, the AcrySof MA60BM IOL was significantly associated with the presence of deposits (adjusted odds ratio ¼ 38.5, 95% CI 6.9-200, Po0.001). Using multiple regression analysis, there was a significant association between the severity of deposits and the use of the AcrySof MA60BM IOL (P ¼ 0.005). Compared with other foldable IOLs implanted, the AcrySof MA60BM IOL was 38.5 times more likely to develop intra-IOL deposits. There was no association with those eyes that had undergone increased intraocular manipulations. The deposits did not appear to affect visual acuity. Conclusions To our knowledge the finding of brown intra-IOL deposits has not previously been described. These deposits are more frequent in the AcrySof MA60BM implant than the other foldable implants studied. They share some similarities with glistenings, but their exact nature remains unknown.

show abstract

Foreign-Body Reaction Against Intraocular Lenses

Cited by 79 publications

References 18 publications

Cytology of Human Intraocular Lenses

Cytology of Human Intraocular Lenses

Biological Compatibility of Polymethyl Methacrylate, Hydrophilic Acrylic and Hydrophobic Acrylic Intraocular Lenses

Brown deposits in the optic of foldable intraocular lenses in patients with uveitis

Contact Info

Product

Resources

About