Foreign Body Infection: Role of Fibronectin as a Ligand for the Adherence of Staphylococcus aureus

Vaudaux, Pierre; Suzuki, Riyoko; Waldvogel, Francis; Morgenthaler, J.‐J.; Nydegger, Urs E.

doi:10.1093/infdis/150.4.546

Cited by 144 publications

(127 citation statements)

References 24 publications

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“…In conclusion, our study has confirmed and extended to another biomaterial (PVC) the role of fibronectin in the adherence of S. aureus Wood 46 [3,5]. have binding sites on the fibronectin molecule, but the type of interaction at the molecular level remains to be studied [2,11].Some information regarding fibronectin as an adherence factor is nevertheless available: in an animal model [4], fibronectin was shown to mediate the attachment of S. aureus Wood 46 to an implanted biomaterial.…”

Section: Discussion Resultssupporting

confidence: 67%

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Monosaccharide Inhibition of Staphylococcus aureus Adherence to Human Solid-Phase Fibronectin

Velazco

Waldvogel

1987

Journal of Infectious Diseases

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Section: Discussion Resultssupporting

confidence: 67%

“…Staphylococci and streptococci bind to the amino-terminal region of fibronectin [1,2]. Fibronectin promotes adherence of staphylococcal cells to polymethylmethacrylate (a material widely used in prosthetic devices) in vitro [3] and in vivo [4,5]. There are conflicting data regarding the chemical structure of bacterial receptors for fibronectin [6,7].…”

mentioning

confidence: 99%

Monosaccharide Inhibition of Staphylococcus aureus Adherence to Human Solid-Phase Fibronectin

Velazco

Waldvogel

1987

Journal of Infectious Diseases

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“…Recently, Vaudaux and co-workers reported that different inserted materials reacted similarly with respect to their coating by host proteins. 6 We also found no differences between polystyrene tissue culture plates and PVC plates (which were compared in some experiments), except that without prior BSA blocking, staphylococcal adherence to non-coated surfaces was up to two times higher with polystyrene than with PVC plates. Recently, Muller et a1.…”

Section: Discussionmentioning

confidence: 55%

Role of fibronectin in staphylococcal colonisation of fibrin thrombi and plastic surfaces

Valentin‐Weigand

Timmis²,

Chhatwal³

1993

Journal of Medical Microbiology

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Summary. The adhesive glycoprotein fibronectin has been proposed as a mediator of adherence of certain gram-positive cocci to host cells and fibrin thrombi. This study compared the role of soluble and immobilised fibronectin in the adherence of coagulasenegative staphylococci (CNS) and Staphylococcus aureus to fibrin thrombi and plastic surfaces. Adherence of S. epidermidis to fibrin thrombi was significantly reduced when fibronectin was removed from the plasma used for thrombus preparation. Adherence was restored through restitution of fibronectin. S. epidermidis also adhered substantially more to plastic surface coated with fibronectin than to non-coated plastic. Increased adherence of CNS to plastic was also observed after coating with the 29-kDa N-terminal fragment of fibronectin. Soluble fibronectin did not affect the adherence of CNS to fibrin thrombi or plastic surfaces. The adherence of S. aureus to fibrin thrombi was significantly increased by the addition of soluble fibronectin, but not by incorporation of fibronectin into the clot. These results indicate that the binding of fibronectin is an important factor in the adherence of staphylococci to fibrin clots and plastic surfaces and, thus, colonisation of these surfaces. However, the two species of staphylococci seem to employ different mechanisms of fibronectin-mediated adherence : S. epidermidis interacts mainly with fibronectin incorporated in fibrin clots or immobilised on implanted synthetic materials, whereas S. aureus adheres to the fibrin matrix through binding of soluble fibronectin present in wound exudates.

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“…Fibronectin is one of the many binding sites (receptors) for Staphylococcus aureus [11][12][13]16]. The transformed cell line HEp-2, lacks fibronectin [35][36][37].…”

Section: Discussionmentioning

confidence: 99%

“…A number of staphylococcal adherence factors related to invasion and infection have been identified, but their role in colonisation of intact epithelium is unclear. These factors ¶ e-mail: gary.french@kcl.ac.uk Tel: +44 20 7 928 9292 x3244 Fax: +44 20 7 928 0730 include those expressed by human cells, such as vitronectin, fibronectin, fibrinogen, elastin, collagen and heparan sulphate [11][12][13][14][15], and those expressed by the bacterium, including lipoteichoic acid, techoic acid, protein A [16][17][18] and capsular polysaccharides [19].…”

Section: Introductionmentioning

confidence: 99%

Highly Epidemic Strains of Methicillin-Resistant Staphylococcus aureus Not Distinguished by Capsule Formation, Protein A Content or Adherence to HEp-2 Cells

Aathithan

Dybowski

French

2001

EJCMID

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During the 1990s, two strains of epidemic methicillin-resistant Staphylococcus aureus, designated 'phage types EMRSA-15 and EMRSA-16, have emerged as significant hospital pathogens. They have resisted standard methods of control and spread widely amongst in the UK, often becoming endemic, while the incidence of other epidemic types of MRSA has either declined or not changed. This suggests that EMRSA-15 and EMRSA-16 possess special properties that favour their dissemination and survival. In order to investigate this hypothesis, a study was undertaken that examined methicillin-sensitive and methicillinresistant strains of Staphylococcus aureus, including EMRSA types 1, 2, 3, 15 and 16, for capsule formation, the amount of bound protein A produced, and quantitative adherence to the human continuous epithelial cell line HEp-2. Although all these properties varied amongst the strains examined, there was no relationship between any of them and methicillin resistance or epidemic type, and, incidentally, no relationship between cell-wall bound protein A content and adherence.

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Foreign Body Infection: Role of Fibronectin as a Ligand for the Adherence of Staphylococcus aureus

Cited by 144 publications

References 24 publications

Monosaccharide Inhibition of Staphylococcus aureus Adherence to Human Solid-Phase Fibronectin

Monosaccharide Inhibition of Staphylococcus aureus Adherence to Human Solid-Phase Fibronectin

Role of fibronectin in staphylococcal colonisation of fibrin thrombi and plastic surfaces

Highly Epidemic Strains of Methicillin-Resistant Staphylococcus aureus Not Distinguished by Capsule Formation, Protein A Content or Adherence to HEp-2 Cells

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