Foreign Body Granuloma After Cranial Surgery: A Systematic Review of Reported Cases

Akhaddar, Ali; Turgut, Ahmet Tuncay; Turğut, Mehmet

doi:10.1016/j.wneu.2018.09.143

Cited by 18 publications

(26 citation statements)

References 79 publications

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“…Akhaddar and Turgut in our recent manuscript published in this journal [2]. Since acceptance of our manuscript, they have communicated a systematic review on foreign body granulomas following cranial surgery in World Neurosurgery [1]. We wish to congratulate them for their thoughtful and comprehensive analysis.…”

mentioning

confidence: 96%

Intracranial foreign material granuloma after neurosurgical procedures

Al-Afif

Krauss

2018

Acta Neurochir

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confidence: 96%

Intracranial foreign material granuloma after neurosurgical procedures

Al-Afif

Krauss

2018

Acta Neurochir

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“…Notably, our patients were quite young (median age, 30.5 years). A recent systematic review ( n = 100 cases of intracranial FBG) identified an average patient age of 42.2 years at time of FBG diagnosis [3]. Whether or not younger age may constitute a risk factor for FBG development (e.g., by virtue of a more active immune status) remains an area of future investigation.…”

Section: Discussionmentioning

confidence: 99%

“…The clinical presentation of patients with intracranial FBG is variable. Depending on time of onset postsurgery, and lesion size and location, patients may present with new or worsening neurologic signs and symptoms [3, 4]. Interestingly, nearly all our patients remained asymptomatic from the new enhancing lesion detected during routine follow‐up imaging.…”

Section: Discussionmentioning

confidence: 99%

“…By contrast, intracranial FBG is considered a relatively rare phenomenon, with an estimated incidence between 0.1 –and 1 per 1,000 cranial procedures [3, 4], although the true number is likely higher as most patients may not undergo additional surgery to confirm the diagnosis. Presently, only approximately 100 cases of intracranial FBG have been reported in the literature [3]. Most appear to be caused by synthetic materials intentionally left in place, including nonabsorbable Teflon, suture, or cotton material and absorbable hemostatic material [4–6].…”

Section: Introductionmentioning

confidence: 99%

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Intracranial Foreign Body Granuloma Mimicking Brain Tumor Recurrence: A Case Series

et al. 2021

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Background. Intracranial foreign body granuloma (FBG) is a rare inflammatory reaction to retained foreign material, manifesting acutely or months to years following neurosurgical procedures. Radiographically, FBG can mimic tumor progression, and tissue biopsy may be required to guide management. Materials and Methods. In this retrospective case series, we present unique clinico-radiographic and histopathological features of six neuro-oncological patients diagnosed with FBG between 2007 and 2019. Results. All six patients (4 women and 2 men, aged 29-54 [median, 30.5] years) had undergone surgical resection of a low-(n = 4) or high-grade (n = 2) glioma. FBG manifestation postsurgery ranged from 1 day to 4 years and was predominantly asymptomatic (n = 5/6). Magnetic resonance imaging universally demonstrated one or multiple peripherally enhancing lesion(s) adjacent to the resection cavity. Histopathology in all (n = 4/4) resected specimens demonstrated an inflammatory reaction to foreign material, confirming FBG. Conclusion. Intracranial FBG constitutes a rare but challenging treatment-related condition effectively managed by surgery, with important therapeutic implications in neurooncology.

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“…Neurosarcoidosis is present in 5% of patients with systemic sarcoid [14]. There have been 100 cases of intracranial granulomas as of December 2018 due to foreign bodies remaining after cranial surgeries [15]. Tuberculomas, a common infectious etiology, represent 10 to 30% of all intracranial space occupying lesions in patients in tuberculosis endemic zones [16].…”

Section: Discussionmentioning

confidence: 99%

Spontaneous necrotizing granuloma of the cerebellum: a case report

et al. 2020

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Background: Intracranial necrotizing granulomatous space-occupying lesions are sparsely reported in literature. Variability in presenting symptomatology and radiographic features makes diagnostic work-up difficult. Case presentation: This report presents the case of a 77-year-old female with sinusitis and fatigue who underwent an MRI revealing a posterior fossa lesion compressing the fourth ventricle. Subsequent contrast CT of the chest, abdomen, and pelvis was negative for primary malignancy. Histopathologic examination of the lesion following biopsy showed it to be a necrotizing granuloma in an antineutrophil cytoplasmic antibody (ANCA) negative patient. The most likely diagnosis was determined to be spontaneous necrotizing granuloma, a rare entity with only one previous report noted. Conclusions: Spontaneous necrotizing granuloma of the CNS is a rare entity that represents an important differential consideration in the work-up of space occupying lesions of the CNS.

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Foreign Body Granuloma After Cranial Surgery: A Systematic Review of Reported Cases

Cited by 18 publications

References 79 publications

Intracranial foreign material granuloma after neurosurgical procedures

Intracranial foreign material granuloma after neurosurgical procedures

Intracranial Foreign Body Granuloma Mimicking Brain Tumor Recurrence: A Case Series

Spontaneous necrotizing granuloma of the cerebellum: a case report

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