Foreign Body Giant Cell Reaction Associated with Epidermoid Tumor

Moran, Catherine C.; Vakili, Saeed T.; Caldemeyer, Karen S.; Smith, Richard R.

doi:10.1097/00004728-199507000-00024

Cited by 19 publications

(10 citation statements)

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“…Foreign giant cell reaction, an inflammatory giant cell reaction of the ruptured epidermoid cyst, may also occur in the brain parenchyma (2). Moran et al (4) suggested that the epidermoid cyst in their patient may have ruptured spontaneously into the adjacent brain parenchyma, leading to an intense local inflammatory response with the presence of multinucleated giant cells (4). In such cases, MRI may show an enhanced region with associated vasogenic edema.…”

Section: Discussionmentioning

confidence: 99%

“…Typical magnetic resonance imaging (MRI) features include lesions with signal intensity slightly greater than that of the cerebrospinal fluid on T1-weighted imaging and high density on T2-weighted imaging without contrast enhancement (2,3). The presence of contrast enhancement within or adjacent to an epidermoid cyst is rare, but may indicate various conditions including giant cell reaction, coexistence of different histological types and malignant transformation of the epidermoid cyst (4)(5)(6).…”

Section: Introductionmentioning

confidence: 99%

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Malignant transformation of an epidermoid cyst in the temporal and prepontine region: Report of a case and differential diagnosis

2016

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Abstract. Malignant transformation of an epidermoid cyst is rare. The current report presents a case of a 55-year-old female patient with squamous cell carcinoma arising from a benign epidermoid cyst in the left temporal region and prepontine area. She had undergone subtotal resection of an epidermoid cyst 7 months previously. Preoperative imaging findings included a focal enhancing area adjacent to the lesion. Postoperative computed tomography demonstrated an increase in the size of the enhancing area. The patient underwent removal of the lesion and postoperative histological examination revealed a squamous cell carcinoma possibly arising from the epidermoid cyst. Accurate diagnosis of malignant transformation prior to operation is difficult; however, the possibility of an intracranial epidermoid cyst must be considered if a focally enhancing area is visible. Postoperative histological examinations may be used to determine a definite diagnosis, and accurate diagnosis is important for planning a rational therapeutic strategy.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Malignant transformation of an epidermoid cyst in the temporal and prepontine region: Report of a case and differential diagnosis

2016

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“…Thus, histologic diagnosis should be confirmed prior to initial treatment for malignancy. 1,67,73 6. Differential diagnosis…”

Section: Radiologymentioning

confidence: 99%

Clinical characteristics and diagnostic imaging of epidermoid tumors

Nagasawa

Yew

Safaee

et al. 2011

Journal of Clinical Neuroscience

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“…Internal enhancement is seen only in exceptional situations such as malignant transformation [14][15][16][17] or spillage of the cyst contents into the brain parenchyma, resulting in inflammatory change. 18 Pathologically, a focal area of capillary aggregation corresponded to the enhanced area. We speculate that an episode of infection or other irritative situation had provoked neovascularization in the epidermoid cyst.…”

Section: Discussionmentioning

confidence: 99%

Intradiploic epidermoid cyst with focal internal enhancement

et al. 2006

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We report a case of intradiploic epidermoid cyst with focal internal enhancement. The patient was a 55-year-old woman presenting with right temporal head protrusion and head heaviness. Skull radiography and computed tomography demonstrated an expansile mass in the right diploic space. On magnetic resonance imaging, the mass showed makedly high signal T2-weighted images (T2WI) and intermediate to low signal on T1WI. On contrast-enhanced T1WI, there was nodular internal enhancement, which corresponded to neovascularity on pathology, as well as rim-like enhancement. It should be noted that internal enhancement, an indicator of malignant transformation, may be seen even in a benign epidermoid cyst.

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Foreign Body Giant Cell Reaction Associated with Epidermoid Tumor

Cited by 19 publications

References 0 publications

Malignant transformation of an epidermoid cyst in the temporal and prepontine region: Report of a case and differential diagnosis

Malignant transformation of an epidermoid cyst in the temporal and prepontine region: Report of a case and differential diagnosis

Clinical characteristics and diagnostic imaging of epidermoid tumors

Intradiploic epidermoid cyst with focal internal enhancement

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