Foreign Body Cyst Reaction to Porcine Acellular Dermal Matrix (ENDURAGen)

Pasricha, Neel D; Copperman, Thomas S; Crawford, J. Brooks; Kersten, Robert C.

doi:10.1097/iop.0000000000001364

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“…In ophthalmology, foreign body cyst reactions have been reported to both decellularized membrane (TarSys) and acellular dermal matrix (ENDURAGen) when used subcutaneously. 7,8 Similarly, Restore SIS, an acellular porcine collagenous matrix which was recommended for rotator cuff repair, was found in studies to elicit an inflammatory reaction and on nested PCR found to contain porcine DNA material. Animal studies revealed that implantation did cause a massive inflammatory reaction in porcine materials tested in this scenario.…”

Section: Discussionmentioning

confidence: 99%

Foreign Body Reaction Requiring Re-Exploration After Tympanoplasty With Porcine Small Intestinal Submucosa Reconstruction

Fullerton,

Wei,

Green

et al. 2023

Ann Otol Rhinol Laryngol

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Objective: We present the first published case of large foreign body reaction to Biodesign (Cook Medical, Bloomington, IN), an acellular otologic graft matrix derived from porcine small intestinal submucosa, after use in tympanoplasty surgery in a patient without previous exposure to meat products. Methods: A single case report of a 39-year-old female who developed tinnitus, ear drainage, and large fibrotic mass in external auditory canal and extending into middle ear after Type I medial graft tympanoplasty with Biodesign Graft. Left endoscopic microdissection and resection of the tympanic membrane and middle ear fibrotic mass were performed. Main findings: Surgical excision of the fibrous mass required extensive microdissection to ensure preservation of the ossicles and chorda tympani. Postoperatively, hearing improved and otalgia and otorrhea resolved. Conclusions: We report the first case of post-tympanoplasty reaction with the use of Biodesign acellular porcine graft in a patient with no previous known exposure to meat products. Although this presentation appears to be rare, it reinforces the need for careful patient selection and counseling around the use of porcine or other foreign grafts.

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Section: Discussionmentioning

confidence: 99%