Foreign Body Associated Anorectal Abscess

Бутырский, А Г; Novodranov, V.; Kuzhekina, Yu.; Khilko, S.

doi:10.29039/2070-8092-2020-23-1-124-127

Cited by 1 publication

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“…Сахарный диабет (СД) -одно из частых хронических заболеваний, которое относится к «неинфекционной эпидемии XXI века» в связи с его большим риском инвалидизации и высокой летальности пациентов [1].…”

Section: Introductionunclassified

Analysis of Platelet Aggregation in Patients With Diabetic Foot Syndrome

Stavchikov,

Zinovkin,

Marochkov

2024

Journal GrGMU

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Purpose. To analyze the aggregation function of platelets in patients with diabetic foot syndrome (DFS). Material and methods. Prospective clinical trial in which 31 patients participated have been conducted by us. To achieve this purpose, 2 groups have been formed: group 1 – patients with no history of diabetes (n=17); group 2 – patients with diabetes mellitus type 2 complicated by DFS (n=14). The studying of platelet aggregation was carried out once for first days after the admission of patients to the general somatic health care units, turbidimetric count method with an inductor: adenosine diphosphate (ADP) (concentrations of 0.3 mcg/ml, 0.6 mcg/ml, 1.25 mcg/ml and 2.5 mcg/ml were used), adrenaline (concentrations of 2.5 microns and 5.0 microns were used), collagen – 2 mg/ml. Results. In group 2 patients, the average platelet aggregation time, as well as in group 1, was lower than the reference values with an ADP inducer at a dose of 0.6 mcg/ml, 1.25 and 2.5 mcg/ml, and higher with adrenaline at a dose of 2.5 microns and with adrenaline at a dose of 5.0 microns. The degree of aggregation was lower than normal when used with all inducers except ADP 0.3 mcg/ml (normal), and the average platelet aggregation rate was lower with adrenaline. With the other inducers, platelet aggregation parameters were within the reference values. When adding inducers with all platelet aggregation parameters, significant differences were obtained between the two groups (p<0.05), and only when using ADP at doses of 0.6 mcg/ml, 1.25 mcg/ml and 2.5 mcg/ml, no significant differences were obtained for the aggregation rate parameter (p>0.05). Conclusion. In patients with DFS, compared with the people without diabetes mellitus type 2, the lowest degree of aggregation is noted with the use of ADP and adrenaline, the aggregation time is less with ADP, the aggregation rate is less with adrenaline and collagen 2 mg /ml. The degree of aggregation has increased with the use of collagen, and the aggregation time with adrenaline and collagen. The studying of platelet function is an important link in the laboratory control of spontaneous aggregation, which will limit the appearance of new vascular occlusions in patients with DFS.

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Section: Introductionunclassified