Forehead biconvexity enhancement with fat grafting

Supplementation of Facial Fat Grafting to Increase Volume Retention: A Systematic Review

“… 4 , 19 , 44 , 67 , 105 , 108 , 110 , 113-116 , 119 Four studies reported dropouts and reported the number of participants who completed the follow up. 101 , 105 , 107 , 118 Based on the EPHPP guidelines, 20 studies had an overall final rating of weak, 6 studies were rated as moderate, and only 1 study was rated as strong (4%). 106 Data pooling and meta-analysis was not possible due to heterogeneity across studies in terms of clinical features, eg, population characteristics, indications, supplementation strategies, and additional interventions (facelift, additional injections), and methodologic characteristics, eg, assessment tools, study design, and follow up.…”

“…Repeated supplemented fat graft injections were performed in 11 studies and concerned merely supplementation with SVF and cellular components. 19 , 34 , 108-113 , 115 , 117 , 118 A minority of studies reported supplement concentrations: platelet concentration in PRP or PRF was 0.8 × 10 9 to 3.6 × 10 9 /mL (mean [standard deviation], 2.6 [1.3] × 10 9 /mL), and the number of nucleated cells in cSVF or tSVF was 0.3 × 10 5 to 100 × 10 5 cells. 112 , 107 , 109 Some studies reported a concentration range of fat-supplemented therapy and the single addition of bone marrow–derived stromal cells (BMSCs) ranged from 3 to 86 × 10 8 at a volume ratio of 2:1 of BMSC:fat graft.…”

“… 102 , 104 , 112 Follow up was sometimes not reported or ranged considerably within studies (3-30 months). 109 , 112 , 113 , 118 …”