Forebrain substrates of reward and motivation

Wise, Roy A.

doi:10.1002/cne.20689

Cited by 258 publications

(214 citation statements)

References 129 publications

(167 reference statements)

Supporting

Mentioning

203

Contrasting

Unclassified

Order By: Relevance

“…It is well documented that cocaine, methamphetamine or opiates act on a common neural substrate, i.e., the mesolimbic DA projection pathway (Wise, 2005;Xi and Gardner, 2007) by different mechanisms. For example, cocaine elevates extracellular DA by blocking DA transporters, while methamphetamine-induced increase in DA is mediated predominantly by reversal of DA transporter (Wise, 2005). In contrast, opiate-induced activation of the mesolimbic DA system is indirectly mediated by inhibition of VTA GABAergic neurons, which subsequently disinhibits VTA DA neurons (Xi and Stein, 2002).…”

Section: Discussionmentioning

confidence: 99%

“…In addition, it also has high binding affinity for α 1 -and α 2 -adrenergic receptors and several serotonin (5-hydroxytryptamine; 5-HT) receptors (5-HT 1A , 5-HT 4 and 5-HT 7 ) (Mantsch et al, 2007; Shijiang Li at the Medical College of Wisconsin, unpublished data). Given that cocaine is also a non-selective monoamine (DA, norepinephrine and 5-HT) reuptake inhibitor (Wise, 2005), the similar binding properties of l-THP for monoamine receptors suggest that l-THP may act as a natural cocktail-like cocaine antagonist. Recent studies have shown that l-THP significantly inhibits cocaine-or methamphetamineinduced conditioned place preference (Ren et al, 2000;Luo et al, 2003), cocaine selfadministration under fixed-ratio (FR) reinforcement and cocaine-triggered reinstatement of drug-seeking behavior in rats (Mantsch et al, 2007).…”

Section: Levo-tetrahydropalmatine (L-thp) Is a Purified Active Ingredmentioning

confidence: 99%

“…Therefore, in the present study, we investigated: 1) whether l-THP inhibits cocaine self-administration under both FR and progressive-ratio (PR) reinforcement, and cocaine-enhanced brain stimulation reward (BSR). Both PR self-administration and BSR are thought to be sensitive and reliable paradigms to evaluate a drug's rewarding effects (Gardner, 2000;Wise, 2005); 2) whether the same doses of l-THP inhibit locomotion or sucrose self-administration; 3) whether l-THP itself has rewarding or aversive effects in the BSR paradigm; and finally, 4) whether a presynaptic or postsynaptic DA receptor mechanism underlies l-THP's potential therapeutic actions by measuring brain DA responses to cocaine in the presence or absence of l-THP using in vivo brain microdialysis.…”

Section: Levo-tetrahydropalmatine (L-thp) Is a Purified Active Ingredmentioning

confidence: 99%

“…In light of the important role of the mesolimbic dopamine (DA) system in drug abuse (Wise, 2005), much attention has focused on various DA receptor antagonists as potential treatments (Rothman and Glowa, 1995;Platt et al, 2002). However, clinical trials with D 1 or D 2 receptor antagonists for cocaine addiction have failed due to either ineffectiveness, surmountability by increased drug intake, and/or unfavorable side-effects such as dysphoria, extrapyramidal movements or inhibition of natural reward (Sherer et al, 1989;Nann-Vernotica et al, 2001;Haney et al, 2001;Newton et al, 2001; see reviews by Platt et al, 2002;Gorelick et al, 2004).…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Levo-tetrahydropalmatine inhibits cocaine's rewarding effects: Experiments with self-administration and brain-stimulation reward in rats

Zheng

et al. 2007

Neuropharmacology

View full text Add to dashboard Cite

It was recently reported that levo-tetrahydropalmatine (l-THP), a dopamine (DA) D 1 and D 2 receptor antagonist purified from the Chinese herb Stephanie, appears to be effective in attenuating cocaine self-administration, cocaine-triggered reinstatement and cocaine-induced conditioned place preference in preclinical animal models. The present study was designed to contrast l-THP's effects on cocaine self-administration under fixed-ratio (FR) and progressive-ratio (PR) reinforcement, and to study l-THP's effects on cocaine-enhanced brain stimulation reward (BSR). Systemic administration of l-THP produced dose-dependent, biphasic effects, i.e., low-to-moderate doses (1, 3, 10 mg/kg) increased, while a high dose (20 mg/kg) inhibited cocaine self-administration behavior under FR2 reinforcement. The increased cocaine self-administration is likely a compensatory response to a reduction in cocaine's rewarding effects, because the same low doses of l-THP dosedependently attenuated cocaine self-administration under PR reinforcement and also attenuated cocaine-enhanced BSR. These attenuations of PR cocaine self-administration and cocaine-enhanced BSR are unlikely due to l-THP-induced sedation or locomotor inhibition, because only 10 mg/kg, but not 1-3 mg/kg of l-THP inhibited locomotion, sucrose self-administration and asymptotic operant performance in the BSR paradigm. In vivo microdialysis demonstrated that l-THP slightly elevates extracellular nucleus accumbens DA by itself, but dose-dependently potentiates cocaine-augmented DA, suggesting that a postsynaptic, rather than presynaptic, DA receptor antagonism underlies l-THP's actions on cocaine reward. Together, the present data, combined with previous findings, support the potential use of l-THP for treatment of cocaine addiction.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Levo-tetrahydropalmatine (L-thp) Is a Purified Active Ingredmentioning

confidence: 99%

Section: Levo-tetrahydropalmatine (L-thp) Is a Purified Active Ingredmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Levo-tetrahydropalmatine inhibits cocaine's rewarding effects: Experiments with self-administration and brain-stimulation reward in rats

Zheng

et al. 2007

Neuropharmacology

View full text Add to dashboard Cite

show abstract

“…These expectations are assumed to have an effect on behavior through neural processes constantly signaling not only whether the outcome of actions reached the task goals or not but also to what extent these could fit the participants' preconceptions/predictions [14]. According to the theories concerning the brain's reward prediction system, unexpected reward or punishment elicits brief bursts of phasic dopamine signaling originating from the midbrain dopamine system [15,16]. This reward prediction error (RPE) signal is thought to have an interplay with prefrontal cortical areas such as the prefrontal cortex (PFC) and the anterior cingulate cortex (ACC) [14,17,18].…”

mentioning

confidence: 99%

Age-related characteristics of risky decision-making and progressive expectation formation

Kardos

Kóbor

Takács

et al. 2016

Behavioural Brain Research

View full text Add to dashboard Cite

During daily encounters, it is inevitable that people take risks. Investigating the sequential processing of risk hazards involve expectation formation about outcome contingencies. The present study aimed to explore risk behavior and its neural correlates in sequences of decision making, particularly in old age, which represents a critical period regarding risk-taking propensity. The Balloon Analogue Risk Task was used in an electrophysiological setting with young and elderly age groups. During the task each additional pump on a virtual balloon increased the likelihood of a balloon burst but also increased the chance to collect more reward. Event-related potentials associated with rewarding feedback were analyzed based on the forthcoming decisions (whether to continue or to stop) in order to differentiate between states of expectation towards gain or loss. In the young, the reward positivity ERP component increased as a function of reward contingencies with the largest amplitude for rewarding feedback followed by the decision to stop. In the elderly, however, reward positivity did not reflect the effect of reward structure. Behavioral indices of risk-taking propensity suggest that the performance of the young and the elderly were dissociable only with respect to response times: The elderly was characterized by hesitation and more deliberative decision making throughout the experiment. These findings signify that sequential tracking of outcome contingencies has a key role in cost-efficient action planning and progressive expectation formation.Keywords: Aging; Decision making; Feedback-related ERPs; Reward positivity; Risk-taking behavior Whether we are aware of the fact or not, risk-taking behavior occurs more frequently during our everyday actions than generally thought. Besides those simple and common examples like taking only one more drink before driving, a temporary excursion from one's self-regulatory goals, i.e., risking the long-term goals for short-term advantages such as making a cheat in a diet, can be considered as a more complex form of 'gambling' [1]. Risk-taking behavior can be defined as a decision making propensity motivated by gain reward beside the possible opportunity to lose [2][3][4]. Since natural circumstances usually include continuous fluctuations in risk, the ability of making decisions based on the acquisition of action-outcome contingencies is an essential part of adaptive risk behavior [5]. In particular, old age represents a critical period due to substantial neurocognitive changes having an effect on both frontal cortical and subcortical brain areas known to be involved in decision making [6,7]. The question remains, however, whether there is a specific inability of the acquisition of relevant information behind the possibly reduced decision quality of the elderly.From the perspective of self-report questionnaires, elderly are characterized by higher risk-avoidance tendency [8]. However, regarding risk behavior, results show evidence for both normal and altered patterns of ...

show abstract