Forebrain acetylcholine regulates adult hippocampal neurogenesis and learning

Mohapel, Paul; Leanza, Giampiero; Kokaia, Mérab; Lindvall, Olle

doi:10.1016/j.neurobiolaging.2004.07.015

Cited by 289 publications

(224 citation statements)

References 49 publications

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“…Serotoninergic, cholinergic and noradrenergic activation all increase neurogenesis in the dentate gyrus. [31][32][33] GABA, acting through GABA A receptors, decreases proliferation in both the dentate gyrus and the SVZ, 34,35 and dopaminergic signaling has a similar inhibitory effect. [36][37][38] Growth factors also can affect neurogenesis.…”

Section: Regulation Of Adult Neurogenesismentioning

confidence: 96%

Antidepressants and Cdk inhibitors: Releasing the brake on neurogenesis?

Chesnokova¹,

Pechnick²

2008

Cell Cycle

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Section: Regulation Of Adult Neurogenesismentioning

confidence: 96%

Antidepressants and Cdk inhibitors: Releasing the brake on neurogenesis?

Chesnokova¹,

Pechnick²

2008

Cell Cycle

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“…Second, manipulation of rearing or adult environment by in utero lipopolysaccharide (LPS) exposure during the last week of gestational life, lead exposure during the first three postnatal weeks, or vitamin A deficiency from adolescence on, reduce neurogenesis and induce deficits in novel object recognition, reference memory performances, and the formation of fear memories (Jaako-Movits and Zharkovsky 2005; Jaako- Bonnet et al 2008;Graciarena et al 2010). Finally, a lesion of the cholinergic septohippocampal pathway (Mohapel et al 2005) impairs spatial learning and reduces neurogenesis.…”

Section: Correlationsmentioning

confidence: 99%

Interaction between Neurogenesis and Hippocampal Memory System: New Vistas

Abrous

Wojtowicz

2015

Cold Spring Harb Perspect Biol

101

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During the last decade, the questions on the functionality of adult neurogenesis have changed their emphasis from if to how the adult-born neurons participate in a variety of memory processes. The emerging answers are complex because we are overwhelmed by a variety of behavioral tasks that apparently require new neurons to be performed optimally. With few exceptions, the hippocampal memory system seems to use the newly generated neurons for multiple roles. Adult neurogenesis has given the dentate gyrus new capabilities not previously thought possible within the scope of traditional synaptic plasticity. Looking at these new developments from the perspective of past discoveries, the science of adult neurogenesis has emerged from its initial phase of being, first, a surprising oddity and, later, exciting possibility, to the present state of being an integral part of mainstream neuroscience. The answers to many remaining questions regarding adult neurogenesis will come along only with our growing understanding of the functionality of the brain as a whole. This, in turn, will require integration of multiple levels of organization from molecules and cells to circuits and systems, ultimately resulting in comprehension of behavioral outcomes.

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“…GABA modulates neurogenesis, but appears to do so by altering cell differentiation, not survival (Tozuka et al, 2005, Karten et al, 2006. Manipulations of ACh levels can alter both proliferation and survival (Cooper- Kuhn et al, 2004, Mohapel et al, 2005. However, a recent paper showed that chronic acetylcholinesterase (AChE) antagonist treatment results in increased cell survival in the SGZ without affecting cell proliferation or fate (Kotani et al, 2006).…”

Section: Possible Mechanisms For Mor Regulation Of Neurogenesismentioning

confidence: 99%

Knockout of the mu opioid receptor enhances the survival of adult-generated hippocampal granule cell neurons

Harburg¹,

Hall²,

Harrist³

et al. 2007

Neuroscience

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Recent evidence suggests that mu opioid receptors (MOR) are key regulators of hippocampal structure and function. For example, exogenous MOR agonists morphine and heroin negatively impact hippocampal function and decrease adult hippocampal neurogenesis. Here we explored the role of MOR in the birth and survival of hippocampal progenitor cells by examining adult neurogenesis in mice that lack MOR. Adult male mice lacking exon 1 of MOR were injected with the S phase marker bromodeoxyuridine (BrdU) and sacrificed either two hours or four weeks later to evaluate proliferating and surviving BrdU-immunoreactive (IR) cells, respectively, in the adult hippocampal granule cell layer. WT, heterozygote, and homozygote mice did not differ in the number of BrdU-IR cells at a proliferation time point. However, four weeks after BrdU injection, heterozygote and homozygote mice had 57% and 54% more surviving BrdU-IR cells in the hippocampal granule cell layer as compared to WT mice. A decrease in apoptosis in the heterozygote and homozygote mice did not account for the difference in number of surviving BrdU-IR cells since there were no alterations in number of pyknotic, TUNEL-positive, or activated caspase 3-IR cells compared to WT. In concordance with the increased numbers of granule cells maturing into neurons, heterozygote and homozygote mice had larger hippocampal granule cell layers and increased numbers of granule cells. These findings indicate that MOR may play a role in regulating progenitor cell survival and more generally encourage further exploration of how MOR activation can influence hippocampal structure and function.

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Forebrain acetylcholine regulates adult hippocampal neurogenesis and learning

Cited by 289 publications

References 49 publications

Antidepressants and Cdk inhibitors: Releasing the brake on neurogenesis?

Antidepressants and Cdk inhibitors: Releasing the brake on neurogenesis?

Interaction between Neurogenesis and Hippocampal Memory System: New Vistas

Knockout of the mu opioid receptor enhances the survival of adult-generated hippocampal granule cell neurons

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