Forearm vasoconstrictor response in uncomplicated type 1 diabetes mellitus

Abstract

Baseline FVR and sympathetic nerve activity are normal in patients with uncomplicated type 1 diabetes. However, the forearm vasoconstrictor response to sympathetic stimulation is attenuated, which cannot be attributed to an impaired sympathetic responsiveness.

Role of nitric oxide and endothelin in endothelial maintenance of vasoconstrictor responses in aortas of diabetic female rats (一氧化氮与内皮素对糖尿病雌性大鼠主动脉血管内皮维持血管收缩反应的影响)

“…Changes in vascular reactivity to vasoconstrictor agents have been observed in both animal models of diabetes and in patients with type 1 diabetes mellitus, although the results are not consistent. Specifically, unaltered, increased, and attenuated contractile vascular responses have been reported. Experimental variables such as sex, the type of artery, the vasoconstrictor agent tested, and the duration of diabetes may explain the apparent discrepancies between studies …”