Accurate reduction is a critical component in the surgical treatment of ankle syndesmotic injuries, as it restores the joint anatomy and results in superior clinical outcomes. Data suggest a high incidence of malreduction in the treatment of syndesmotic injuries. This article describes the center-center technique for syndesmosis screw insertion. The technique defines the neutral anatomic axis of the distal tibiofibular joint, and improves the surgeon's ability to determine the ideal start point, clamp position, and screw trajectory. The technique avoids potential malreduction caused by suboptimal clamp and screw placement.Level of Evidence: Diagnostic Level 5. See Instructions for Authors for a complete description of levels of evidence.Ankle fractures are one of the most common operatively treated injuries for orthopedic surgeons. It has been estimated that approximately 23% of ankle fractures involve damage to the distal tibiofibular syndesmosis. 1 A critical step in the treatment of ankle fractures is accurate reduction of the syndesmosis to restore the overall anatomy and function of the ankle joint and prevent ankle arthritis. 2 Reduction of the syndesmosis has been cited as the only significant predictor of functional outcome in a retrospective review of 51 ankle fractures by Weening and Bhandari. 3 Despite the common occurrence of syndesmotic injuries and the importance of accurate fixation, there is a high incidence of malreduction of the syndesmosis. The rates of syndesmotic malreduction have previously been reported to be between 0% and 16%. 3-5 However, Gardner et al 6 demonstrated a syndesmotic malreduction rate of 52% in ankles treated with traditional screw fixation and evaluated with postoperative computed tomographic (CT) scan. A subsequent study by Miller et al 7 reported a decrease in the malreduction rate to 15% when an open technique and direct visualization were used. Given these unacceptably high rates of malreduction, surgeons have sought to reevaluate and improve upon the techniques and intraoperative imaging used to treat and assess syndesmotic reduction.A commonly used technique for syndesmosis fixation involves stabilization of the tibiofibular joint with a reduction clamp, evaluation of the reduction with 2-dimensional (2D) fluoroscopy, and placement of a trans-syndesmotic screw. Traditional teaching dictates that the surgeon angle the screw at 30 degrees to match the neutral anatomic axis.Cadaveric data indicate that both improper clamp and screw placement can lead to malreduction and overcompression of the syndesmosis. 7 Ideally, the clamp and screw would both be placed along the neutral axis to avoid malreduction. This problem with malreduction caused by off-axis clamp and screw placement has been further demonstrated by Phisitkul et al. 8 Miller and colleagues recommended more anterior screw trajectory for a screw through a posterior plate, and a more posterior trajectory for a lateral plate. Needleman 9 has described a glide path technique that uses direct K wire reduction along ...