Forceps minor damage and co-occurrence of depression and fatigue in multiple sclerosis

Gobbi, Claudio; Rocca, Maria A.; Pagani, Elisabetta; Riccitelli, Gianna Carla; Pravatà, Emanuele; Radaelli, Marta; Boneschi, Filippo Martinelli; Falini, Andrea; Copetti, Massimiliano; Comi, Giancarlo; Filippi, Massimo

doi:10.1177/1352458514530022

Cited by 61 publications

(66 citation statements)

References 37 publications

(48 reference statements)

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“…The FMi connects the lateral and medial surfaces of the frontal lobes crossing the midline via the genu of the corpus callosum. Damage of the FMi detected by decreasing FA in DTI imaging has been associated with fatigue and depression in multiple sclerosis (Gobbi et al, 2014). Degradation of FMiin mild cognitive impairment (MCI) and AD relative to HC was found in a cohort study using multiple diffussion measures (Alves et al, 2013).…”

Section: Discussionmentioning

confidence: 99%

White Matter Tract Integrity in Alzheimer's Disease vs. Late Onset Bipolar Disorder and Its Correlation with Systemic Inflammation and Oxidative Stress Biomarkers

Besga

Chyzhyk

González-Ortega

et al. 2017

Front. Aging Neurosci.

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Background: Late Onset Bipolar Disorder (LOBD) is the development of Bipolar Disorder (BD) at an age above 50 years old. It is often difficult to differentiate from other aging dementias, such as Alzheimer's Disease (AD), because they share cognitive and behavioral impairment symptoms.Objectives: We look for WM tract voxel clusters showing significant differences when comparing of AD vs. LOBD, and its correlations with systemic blood plasma biomarkers (inflammatory, neurotrophic factors, and oxidative stress).Materials: A sample of healthy controls (HC) (n = 19), AD patients (n = 35), and LOBD patients (n = 24) was recruited at the Alava University Hospital. Blood plasma samples were obtained at recruitment time and analyzed to extract the inflammatory, oxidative stress, and neurotrophic factors. Several modalities of MRI were acquired for each subject,Methods: Fractional anisotropy (FA) coefficients are obtained from diffusion weighted imaging (DWI). Tract based spatial statistics (TBSS) finds FA skeleton clusters of WM tract voxels showing significant differences for all possible contrasts between HC, AD, and LOBD. An ANOVA F-test over all contrasts is carried out. Results of F-test are used to mask TBSS detected clusters for the AD > LOBD and LOBD > AD contrast to select the image clusters used for correlation analysis. Finally, Pearson's correlation coefficients between FA values at cluster sites and systemic blood plasma biomarker values are computed.Results: The TBSS contrasts with by ANOVA F-test has identified strongly significant clusters in the forceps minor, inferior longitudinal fasciculus, inferior fronto-occipital fasciculus, and cingulum gyrus. The correlation analysis of these tract clusters found strong negative correlation of AD with the nerve growth factor (NGF) and brain derived neurotrophic factor (BDNF) blood biomarkers. Negative correlation of AD and positive correlation of LOBD with inflammation biomarker IL6 was also found.Conclusion: TBSS voxel clusters tract atlas localizations are consistent with greater behavioral impairment and mood disorders in LOBD than in AD. Correlation analysis confirms that neurotrophic factors (i.e., NGF, BDNF) play a great role in AD while are absent in LOBD pathophysiology. Also, correlation results of IL1 and IL6 suggest stronger inflammatory effects in LOBD than in AD.

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Section: Discussionmentioning

confidence: 99%

White Matter Tract Integrity in Alzheimer's Disease vs. Late Onset Bipolar Disorder and Its Correlation with Systemic Inflammation and Oxidative Stress Biomarkers

Besga

Chyzhyk

González-Ortega

et al. 2017

Front. Aging Neurosci.

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“…This has led to identifying specific pathologies within the frontal and parietal cortices [13,43,88,160,175,178], thalami and basal ganglia [13,89,145,149,225], among others. More interestingly, several MS fatigue networks have been described: the fronto-striatal network [157,179,209], the parieto-striatal network [37], the cortico-cortical network mainly involving fronto-frontal and fronto-parietal regions [13,157,169,202,221] and an interhemispheric network consisting of the corpus callosum and its radiating fibers [13,75,178,244,245]. All of them take part in the socalled ''cortico-striato-thalamo-cortical loop'' of MS fatigue [13,22,47,48,54,57,58,70,169,176,177].…”

Section: Anatomical Correlates Of Ms Fatigue: the Cortico-striato-thamentioning

confidence: 98%

Fatigue in multiple sclerosis – Insights into evaluation and management

Ayache

Chalah

2017

Neurophysiologie Clinique/Clinical Neurophysiology

123

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“…Kopitzki and his team had found that damage to the forceps minor may be related to the weakened motor function [38]. The FA value in the forceps minor can predict the rehabilitation outcome of an exercise control [39]. Our study strategy was to place a TMS coil on the contralateral cerebral cortex area M1 and provide SA stimulation on the 2/5 of the ipsilateral MS6 line.…”

Section: Discussionmentioning

confidence: 99%

Scalp acupuncture plus low-frequency rTMS promotes repair of brain white matter tracts in hemiplegic patients with stroke: A diffusion tensor imaging study

Zhao

Zhang

Qiu

et al. 2018

J. Integr. Neurosci.

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To study the clinical effects of scalp acupuncture plus low frequency rTMS in hemiplegic stroke patients. A total of 28 hemiplegic stroke patients were recruited and randomly assigned to the experimental group (scalp acupuncture low frequency rTMS routine rehabilitation treatment) or the control group (scalp acupuncture routine rehabilitation treatment). All patients received a diffusion tensor imaging examination on the day of admission and on the fourteenth day. Compared with pre-treatment, the upper limb motor function score and ability of daily life score increased significantly in the two groups, and motor function improvement was much greater in the experimental group. Fractional anisotropy values significantly increased in white matter tracts, such as the corticospinal tract, forceps minor, superior longitudinal fasciculus and uncinate fasciculus in the two groups. Compared with pretreatment, the fractional anisotropy values increased and mean diffusion values decreased synchronously in the forceps minor, left inferior fronto-occipital fasciculus, left inferior longitudinal fasciculus, left superior longitudinal fasciculus and left uncinate fasciculus in the experimental group. Before and after treatment, there were no significant differences in the changes of fractional anisotropy values between the two groups, but the changes of the mean diffusion values in the experimental group were much greater than those in the control group in the left superior longitudinal fasciculus and the left uncinate fasciculus (p < 0.05). Moreover, the increased fractional anisotropy values in the forceps minor in the experimental group were significantly positively correlated with the increased Fugl-Meyer assessment score. Our study concluded that based on routine rehabilitation treatment, scalp acupuncture plus low frequency rTMS can promote white matter tracts repair better than scalp acupuncture alone; the motor function improvement of the hemiplegic upper limb may be closely related to the rehabilitation of the forceps minor; the combination of scalp acupuncture and low frequency rTMS is expected to provide a more optimal rehabilitation protocol for stroke hemiplegic patients.

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Forceps minor damage and co-occurrence of depression and fatigue in multiple sclerosis

Abstract: This study provides evidence for partially overlapping damage to frontal and fronto-temporal pathways underlying depression and fatigue in MS.

Cited by 61 publications

References 37 publications

White Matter Tract Integrity in Alzheimer's Disease vs. Late Onset Bipolar Disorder and Its Correlation with Systemic Inflammation and Oxidative Stress Biomarkers

White Matter Tract Integrity in Alzheimer's Disease vs. Late Onset Bipolar Disorder and Its Correlation with Systemic Inflammation and Oxidative Stress Biomarkers

Fatigue in multiple sclerosis – Insights into evaluation and management

Scalp acupuncture plus low-frequency rTMS promotes repair of brain white matter tracts in hemiplegic patients with stroke: A diffusion tensor imaging study

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