Forced oscillation technique and impulse oscillometry

Smith, H. J.; Reinhold, Petra; Goldman,

doi:10.1183/1025448x.00031005

Cited by 238 publications

(340 citation statements)

References 107 publications

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“…For lung function testing, the impulse oscillometry system ("MasterScreen-IOS", V Healthcare, Hoechberg, Germany) was used as described by Smith et al [45]. This non-invasive technique was previously validated for conscious calves [29][30][31].…”

Section: Pulmonary Function Testsmentioning

confidence: 99%

“…The following variables of ventilation were analysed: respiratory rate (RR); tidal volume (Vt); volume of minute ventilation (Vmin); both, tidal volume and minute volume related per kg body weight (Vt/kg, Vmin/kg). In order to evaluate respiratory mechanics, respiratory resistance (R) and respiratory reactance (X) were analysed in dependence on frequency [45]. Recalculation of original IOS-data using the software FAMOS (Fast Analysis and Monitoring of Signals; imc Mess-Systeme GmbH, Berlin, Germany) enabled us to calculate R and X for each frequency within the frequency range of 1 to 10 Hz, and separated for inspiration and expiration (R in 1Hz .…”

Section: Pulmonary Function Testsmentioning

confidence: 99%

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A clinically silent respiratory infection withChlamydophilaspp. in calves is associated with airway obstruction and pulmonary inflammation

et al. 2007

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-This study was aimed at evaluating functional and inflammatory consequences of persistent chlamydial infections on the respiratory system in clinically inconspicuous calves aged 2-7 months. Thirteen calves persistently infected with Chlamydophila (C.) abortus and/or C. pecorum (Chl+) were compared to 12 calves without chlamydial infections (Chl-). In order to evaluate lung function, 36 non-invasive impulse oscillometry tests were performed per animal within 6 months. The group of chronically infected animals was distinguished by significantly higher peripheral airway resistance (indicating peripheral airway obstruction), significantly higher respiratory rates, and significantly higher minute volumes of ventilation. At the age of seven months, all calves were necropsied, broncho-alveolar lavage fluid (BALF) was obtained ex vivo, and lungs were examined histologically. Significantly higher concentrations of total protein and 8-iso-prostane (8-IP), as well as higher activities of matrix metalloprotease 2 were measured in BALF samples of Chl+ calves. Histologically, markedly activated bronchus-associated lymphoid tissue (BALT) causing partial obstruction of bronchiolar lumina was found in the apical pulmonary lobes of Chl+ calves. Chlamydial DNA was detected in the lung tissue of 7 out of 13 Chl+ calves by real-time PCR. In conclusion, respiratory chlamydial infection appeared to be associated with chronic inflammation of the lungs and airways. Despite the lack of clinical symptoms, pulmonary dysfunctions persisted in calves until the age of seven months. Data obtained in this study provide new insight illustrating the impact of nearly ubiquitous subclinical infections on the respiratory system. Chlamydia / Chlamydophila infection / airway obstruction / pulmonary inflammation / calves

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Section: Pulmonary Function Testsmentioning

confidence: 99%

Section: Pulmonary Function Testsmentioning

confidence: 99%

A clinically silent respiratory infection withChlamydophilaspp. in calves is associated with airway obstruction and pulmonary inflammation

et al. 2007

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“…Similar to FOT, impulse oscillometry (IOS) is easy to perform and requires only passive patient cooperation [34]. IOS delivers a regular square wave of pressure 5 times per second, and has the advantage of generating a larger sample during measurements thereby emitting a continuous spectrum of frequencies that provide a more detailed characterization of respiratory mechanics [35]. IOS has been employed in adults as well as in preschool asthmatic children to identify lung dysfunction [34,36] and in the clinical diagnostic testing of individuals with airway hyperreactivity and airway obstruction.…”

Section: Functional Assessment Of Peripheral Airwaysmentioning

confidence: 99%

Assessing and accessing the small airways; implications for asthma management

Scichilone

Contoli

Paleari

et al. 2013

Pulmonary Pharmacology & Therapeutics

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a b s t r a c tDespite the wealth of experience in the management of asthma, the disease remains inadequately controlled in some patients, who face long-term respiratory impairment and disability. The disease has been characterised as an inflammatory condition affecting first the larger airways and eventually the smaller airways, but there is evidence that peripheral airway involvement defines a particular and more severe phenotype of asthma. For this reason, assessing functional and biological parameters reflective of small airways involvement is important prognostically. No assessment method is universally and directly representative of peripheral airway function, but the traditional spirometric tests, including vital capacity, residual volume and forced vital capacity, are somewhat correlated with this function; useful methods for further assessment include the single-breath nitrogen wash-out test, impulse oscillometry, nitrous oxide and exhaled breath concentrate measurements, as well as computed tomography to reflect air trapping and response to treatment. Formulation advancements have made for easier treatment access to the smaller airways, with the new extrafine formulations resulting in better asthma control compared with non-extrafine formulations.

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“…23 We used resistance at 5 Hz (R 5 ), 20 Hz (R 20 ), frequency dependence (R [5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20] ) as indicators of total, large, and small airway resistance, respectively; reactance at 5 Hz (X 5 ) was used as an index of the reactance of the overall respiratory system. [23][24][25][26] We also measured resonant frequency (F res ) and integrated area of low-frequency X (AX) as a sensitive measure of small airways obstruction. [24][25][26] Allergy Skin Test Participants were tested with five common allergens, which could be persistent with the workplace: house dust mite (Dermatophagoides pteronyssinus), mixed grass pollen, Cladosporium sp, cat and dog, along with glycerol-saline and histamine controls (Bayer, Elkert, Ind).…”

Section: R T I C L E a R T I C L Ementioning

confidence: 99%