Forced and voluntary exercise counteract insulin resistance in rats: The role of coping style

Boersma, Gretha J.; Barf, R. Paulien; Benthem, Lambertus; Dijk, Gertjan van; Scheurink, Antonius

doi:10.1016/j.yhbeh.2012.05.006

Cited by 13 publications

(6 citation statements)

References 31 publications

(36 reference statements)

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“…The switch from regular chow to MF diet itself revealed marked differences between the RHA and RLA strain, with a larger increment in food intake and RW activity displayed by the RLA rats versus the RHA rats. This is a pattern that we have seen previously in male rats from the same strains (Boersma et al, 2012). In the present study, OLZ treatment has a tendency to reduce caloric intake in the RLA strain and caused a profound reduction in RW activity, which apparently balanced energy homeostasis yielding no differences in body weight or adiposity level between the control and OLZ treated RLA groups.…”

Section: Discussionsupporting

confidence: 89%

Roman high and low avoidance rats differ in their response to chronic olanzapine treatment at the level of body weight regulation, glucose homeostasis, and cortico-mesolimbic gene expression

et al. 2017

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Olanzapine, an antipsychotic agent mainly used for treating schizophrenia, is frequently associated with body weight gain and diabetes mellitus. Nonetheless, studies have shown that not every individual is equally susceptible to olanzapine's weight-gaining effect. Therefore, Roman high and low avoidance rat strains were examined on their responsiveness to olanzapine treatment. The Roman high avoidance rat shares many behavioral and physiological characteristics with human schizophrenia, such as increased central dopaminergic sensitivity, whereas the Roman low avoidance rat has been shown to be prone to diet-induced obesity and insulin resistance. The data revealed that only the Roman high avoidance rats are susceptible to olanzapine-induced weight gain and attenuated glucose tolerance. Here it is suggested that the specific olanzapine-induced weight gain in Roman high avoidance rats could be related to augmented dopaminergic sensitivity at baseline through increased expression of prefrontal cortex dopamine receptor D1 mRNA and nucleus accumbens dopamine receptor D2 mRNA expression. Regression analyses revealed that olanzapine-induced weight gain in the Roman high avoidance rat is above all related to increased prolactin levels, whereas changes in glucose homeostasis is best explained by differences in central dopaminergic receptor expressions between strains and treatment. Our data indicates that individual differences in dopaminergic receptor expression in the cortico-mesolimbic system are related to susceptibility to olanzapine-induced weight gain.

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Section: Discussionsupporting

confidence: 89%

Roman high and low avoidance rats differ in their response to chronic olanzapine treatment at the level of body weight regulation, glucose homeostasis, and cortico-mesolimbic gene expression

et al. 2017

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“…One study using rats examining both forced and voluntary exercise simultaneously illustrated that regardless of exercise method, exercise produces improvements in insulin resistance. 38 Despite these parallel results linking improvements in T2DM and obesity symptoms to any form of exercise, there are differences between forced and voluntary exercise regarding other physiological outcomes. For example, mice consuming a high-fat diet have shown reduced inflammation when given access to running-wheels; 15 conversely, forced exercise may promote inflammation 39 and differently affect the gut microbiome compared to voluntary wheel-running in rodent models.…”

Section: Discussionmentioning

confidence: 99%

Removal of a high-fat diet, but not voluntary exercise, reverses obesity and diabetic-like symptoms in male C57BL/6J mice

Hatzidis

Hicks

Gelineau

et al. 2017

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ObJeCTIVe: both the consumption of high-fat diets and exercise are known to produce alterations in metabolism and behavior. This study focuses on the effects of a change to a lowfat diet from a high-fat diet and voluntary exercise on obesity, type-2 diabetic-like symptoms, and locomotor behavior in male C57BL/6J mice. DeSIgN: Mice were initially given either a high-fat diet or regular chow, along with a cage with a running-wheel to mimic exercise, or one without, to determine to what extend exercise affects these symptoms. Then half of the mice given a high-fat diet were switched to regular chow to ascertain if the switch in diet would improve type-2 diabetic-like and obesity symptoms. ReSUlTS: Wheel-running alone produced an improvement in insulin in mice continuously fed a high-fat diet (p=0.006), but running-wheels did not produce any further improvements in mice with regular chow replacement (p=0.999) or in controls (p=0.996). Replacement of a high-fat diet with regular chow led to physiological improvements in insulin (p=0.012) and leptin (p <0.001), glucose tolerance (p <0.001), and obesity (p <0.001), more so than exercise alone. Mice consuming a high-fat diet without a wheel exhibited reduced home-cage activity compared to controls after the diet switch (p=0.030), while no reduction was found in running-wheel activity between high-fat diet and regular chow consuming mice after switching diets (p=0.516). CONCLUSIONS: These results suggest that exercise is only partially beneficial to improving health outcomes in mice consuming a high-fat diet, whereas incorporating a better diet, even without exercise, improves quality of health and can suppress T2DM symptoms and related conditions more so than exercise alone.

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“…Exercise ameliorates anxiety or depression [1], enhances insulin sensitivity and thus glucose metabolism [2-4], and maintains or improves cognitive function [5, 6] in humans and animals. Physical activity is also highly recommended as a method to prevent multiple health issues such as obesity and cardiovascular disease [7, 8].…”

Section: Introductionmentioning

confidence: 99%

Wheel running decreases palatable diet preference in Sprague–Dawley rats

Moody

Liang

Choi

et al. 2015

Physiology & Behavior

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Physical activity has beneficial effects on not only improving some disease conditions but also by preventing the development of multiple disorders. Experiments in this study examined the effects of wheel running on intakes of chow and palatable diet e.g. high fat (HF) or high sucrose (HS) diet in male and female Sprague Dawley rats. Experiment 1 demonstrated that acute wheel running results in robust HF or HS diet avoidance in male rats. Although female rats with running wheel access initially showed complete avoidance of the two palatable diets, the avoidance of the HS diet was transient. Experiment 2 demonstrated that male rats developed decreased HF diet preferences regardless of the order of diet and wheel running access presentation. Running associated changes in HF diet preference in females, on the other hand, depended on the testing schedule. In female rats, simultaneous presentation of the HF diet and running access resulted in transient complete HF diet avoidance whereas running experience prior to HF diet access did not affect the high preference for the HF diet. Ovariectomy in females resulted in HF diet preference patterns that were similar to those in male rats during simultaneous exposure of HF and wheel running access but similar to intact females when running occurred before HF exposure. Overall, the results demonstrated wheel running associated changes in palatable diet preferences that were in part sex dependent. Furthermore, ovarian hormones play a role in some of the sex differences. These data reveal complexity in the mechanisms underlying exercise associated changes in palatable diet preference.

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Forced and voluntary exercise counteract insulin resistance in rats: The role of coping style

Cited by 13 publications

References 31 publications

Roman high and low avoidance rats differ in their response to chronic olanzapine treatment at the level of body weight regulation, glucose homeostasis, and cortico-mesolimbic gene expression

Roman high and low avoidance rats differ in their response to chronic olanzapine treatment at the level of body weight regulation, glucose homeostasis, and cortico-mesolimbic gene expression

Removal of a high-fat diet, but not voluntary exercise, reverses obesity and diabetic-like symptoms in male C57BL/6J mice

Wheel running decreases palatable diet preference in Sprague–Dawley rats

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