Force Measurement for the Interaction between Cucurbit[7]uril and Mica and Self-Assembled Monolayer in the Presence of Zn<sup>2+</sup> Studied with Atomic Force Microscopy

Bae, Youngin; Hwang, Ilha; Kim, Ikjin; Kim, Kimoon; Park, Chong-Yun

doi:10.1021/acs.langmuir.7b02168

Cited by 8 publications

(5 citation statements)

References 59 publications

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“…Therefore, in principle, these 1–2 nm high globular structures could be consistent with single CB[8] molecules. In addition, this morphology is consistent with previous results 34 . A detailed inspection of the background in the image allows to detect up to two depth levels.…”

Section: Resultssupporting

confidence: 93%

Electrochemical sensor based on the synergy between Cucurbit[8]uril and 2D-MoS2 for enhanced melatonin quantification

Martínez‐Moro¹,

Pozo²,

Vázquez

et al. 2023

Sci Rep

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We present the development of an electrochemical sensor towards melatonin determination based on the synergistic effect between MoS2 nanosheets and cucurbit[8]uril. For the sensor construction cucurbit[8]uril suspensions were prepared in water, and MoS2 nanosheets were obtained by liquid exfoliation in ethanol:water. The sensing platform was topographically characterized by Atomic Force Microscopy. Electrochemical Impedance Spectroscopy experiments allowed us to study the charge transfer process during melatonin oxidation. Moreover, stoichiometry of the resulting complex has also been determined. After the optimization of the sensor construction and the experimental variables involved in the Differential Pulse Voltammetric response of melatonin, detection limit of 3.80 × 10−7 M, relative errors minor than 3.8% and relative standard deviation lower than 4.4% were obtained. The proposed sensor has been successfully applied to melatonin determination in pharmaceutical and biological samples as human urine and serum, with very good recoveries ranging from 90 to 102%.

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Section: Resultssupporting

confidence: 93%

Electrochemical sensor based on the synergy between Cucurbit[8]uril and 2D-MoS2 for enhanced melatonin quantification

Martínez‐Moro¹,

Pozo²,

Vázquez

et al. 2023

Sci Rep

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show abstract

“…Several groups also investigated the host–guest interactions with SMFS measurements (all data were included in Table S1). − In most cases, the researchers only measured the rupture force but did not calculate the associate/disassociate rate constants. Our experimentally determined dissociation rate constants (0.024, 0.135, 0.106 s –1 ) are very close to 0.08 s –1 (Fc-CB[7]) and 0.03 s –1 (Ad-CB[7]) .…”

Section: Resultsmentioning

confidence: 99%

Regulating Host–Guest Interactions between Cucurbit[7]uril and Guests on Gold Surfaces for Rational Engineering of Gold Nanoparticles

Zhang

Gong

Yang

et al. 2020

ACS Appl. Nano Mater.

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Although macrocyclic host engineered nanoparticles have drawn a lot of attention in the past decade, little attention was paid to the binding affinity between the host and guest assembled on nanoparticles. In this work, the interactions between cucurbit[7]uril (CB[7]) and three guests with phenyl (1), adamantyl (2), and ferrocene (3) groups on a gold surface were investigated. Their interactions were classified into four groups. The binding constants between CB[7] and three guests in the solution (group I) were determined by proton nuclear magnetic resonance (1H NMR) and isothermal titration calorimetry (ITC) experiments. The binding constants between CB[7]-stabilized gold nanosphere and guests 1 and 3 (group II) and those between 1-stabilized gold nanosphere and CB[7] (group III) were determined by ITC experiments. The binding constants determined in groups II and III decrease to approximately 20% of those in group I. The interactions between CB[7] and three guests on gold (group IV) were measured by single-molecule force spectroscopy (SMFS). Much lower binding constants than those in other groups were deduced. The hydrophobic and ion–dipole interactions play important roles in the pulling-out process in a thorough SMFS analysis. Furthermore, the CB[7]-capped gold nanospheres with different sizes were prepared, and their binding constant with the free guest (group II) depends on the nanoparticle size. All of these results are of great benefit to the rational design of macrocyclic host engineered nanoparticles for drug delivery and many other applications.

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“…In the previous study, ZnO interacts with the chemotherapeutic agent dox through quinone and phenolic oxygen molecules of the dox aromatic moiety and CB[7], and ZnO can form a nanocomplex through chelating effects. , Hence, dox could be considered to bind to CB[7] via ZnO with considerable binding affinity and form a doxorubicin-ZnO-cucurbit[7]uril (CDZ) nanocomplex. Many studies have revealed that spermine is an overexpressed tumor biomarker in some tumor environments, such as colorectal tumors, and spermine can bind with CB[7] through host–guest interactions .…”

Section: Introductionmentioning

confidence: 99%

Supramolecular Chemotherapy: Noncovalent Bond Synergy of Cucurbit[7]uril against Human Colorectal Tumor Cells

Chen

Meng

et al. 2021

Langmuir

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Supramolecular chemotherapy has drawn increasing interest due to its ability to improve the efficiency of antitumor drugs and fewer associated toxic side effects. In this study, the smart supramolecular cargo, the doxorubicin-ZnO-cucurbit[7]uril (CDZ) nanocomplex, was constructed through ion−dipole interactions between cucurbit[7]uril {CB[7]} and doxorubicin-ZnO (dox-ZnO). The binding affinity of CB[7] and dox-ZnO was determined to be 10 4 M −1 by isothermal titration calorimetry. Importantly, spermine had a stronger binding affinity (10 6 M −1 ) with CB[7] than dox-ZnO through host−guest interactions. In the tumor microenvironment, spermine disassembled the CDZ nanocomplex, and dox was released from the nanocomplex by XRD, UV−visible spectra, and contact angle analysis. Compared to the single drug dox, the CDZ nanocomplex was demonstrated to possess higher activity of killing colorectal tumor cells by confocal laser scanning microscopy and cytotoxicity, which could be attributed to spermine concentration, spermine synthase, free radical damage, and G 1 cell cycle arrest. Overall, the supramolecular delivery of dox can enhance the inhibition of human colorectal tumor cell proliferation and reduce cytotoxicity in human myocardial cells through the noncovalent bond synergy of {CB[7]}.

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Force Measurement for the Interaction between Cucurbit[7]uril and Mica and Self-Assembled Monolayer in the Presence of Zn²⁺ Studied with Atomic Force Microscopy

Cited by 8 publications

References 59 publications

Electrochemical sensor based on the synergy between Cucurbit[8]uril and 2D-MoS2 for enhanced melatonin quantification

Electrochemical sensor based on the synergy between Cucurbit[8]uril and 2D-MoS2 for enhanced melatonin quantification

Regulating Host–Guest Interactions between Cucurbit[7]uril and Guests on Gold Surfaces for Rational Engineering of Gold Nanoparticles

Supramolecular Chemotherapy: Noncovalent Bond Synergy of Cucurbit[7]uril against Human Colorectal Tumor Cells

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Force Measurement for the Interaction between Cucurbit[7]uril and Mica and Self-Assembled Monolayer in the Presence of Zn2+ Studied with Atomic Force Microscopy

Cited by 8 publications

References 59 publications

Electrochemical sensor based on the synergy between Cucurbit[8]uril and 2D-MoS2 for enhanced melatonin quantification

Electrochemical sensor based on the synergy between Cucurbit[8]uril and 2D-MoS2 for enhanced melatonin quantification

Regulating Host–Guest Interactions between Cucurbit[7]uril and Guests on Gold Surfaces for Rational Engineering of Gold Nanoparticles

Supramolecular Chemotherapy: Noncovalent Bond Synergy of Cucurbit[7]uril against Human Colorectal Tumor Cells

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Force Measurement for the Interaction between Cucurbit[7]uril and Mica and Self-Assembled Monolayer in the Presence of Zn²⁺ Studied with Atomic Force Microscopy