Force-induced deformations and stability of biological bonds

Pereverzev, Yuriy V.; Prezhdo, Oleg V.

doi:10.1103/physreve.73.050902

Cited by 53 publications

(81 citation statements)

References 20 publications

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“…The current work applies the bond-deformation concept 18 to rationalize the anomalous behavior of the lifetime of the disulfide bond. 30 The paper is constructed as follows.…”

Section: Introductionmentioning

confidence: 99%

“…The model successfully described the behavior of the P-selectins/ PSGL-1 17 and actin/myosin 10 bonds, see Pereverzev and co-workers, 18,22 respectively. Recent atomistic simulations 9,16,27 as well as experimental data 1 support the deformation interpretation of catch-binding by showing that the proteins forming the bonds undergo large-scale conformational changes involving the binding pocket.…”

Section: Introductionmentioning

confidence: 99%

“…An alternative interpretation of catch-binding was given in Pereverzev and Prezhdo, 18 which used a single dissociation pathway and attributed bond stabilization to a force-induced deformation impeding dissociation of the receptor-ligand bond. The model successfully described the behavior of the P-selectins/ PSGL-1 17 and actin/myosin 10 bonds, see Pereverzev and co-workers, 18,22 respectively.…”

Section: Introductionmentioning

confidence: 99%

“…The catch-slip binding transitions were discovered recently in a number of receptor-ligand biological complexes. 2,3,7,8,10,17,18,[21][22][23][24]26,27,32 The disulfide bond presents the first example of a chemical catch-bond, i.e., a system in which the increased lifetimes are associated with breaking a covalent bond.…”

Section: Introductionmentioning

confidence: 99%

“…The deformation concept allowed us to rationalize not only the catch-behavior but also the large discrepancies between the bond dissociation rate constants obtained by extrapolating the finite force data to zero force and directly without force. 18 Depending on the magnitude and sign of the bond deformation energy, we classified biological bonds as stiff or deformable and as favorably or unfavorably deformed.…”

Section: Introductionmentioning

confidence: 99%

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Deformation Model for Thioredoxin Catalysis of Disulfide Bond Dissociation by Force

Pereverzev

Prezhdo

2009

Cel. Mol. Bioeng.

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Abstract-We develop a theoretical model describing the effect of applied force on the rate of enzymatic dissociation of disulfide bonds (Wiita, A. P. et al., Nature 450:124-127, 2007). The timescale characterizing the extension of the 8-domain protein chain, in which every domain contains a disulfide bond, exhibits anomalous force dependence: The extension time first increases and then decreases with increasing force. This type of force dependence indicates catch-binding and is under active investigation in a variety of systems. The disulfide system presents the first example of a chemical catch-bond. The key difference between the deformation model developed here and the two-pathway model used in the original publication is the bond-deformation term in the force dependence of the dissociation rate constant. The bond-deformation concept provides a different interpretation of the phenomenon. Rather than invoking a new dissociation pathway, which is difficult to rationalize for a simple S-S bond, catch-binding is explained by a force-induced deformation in the protein system disfavoring bond dissociation by thioredoxin. The analysis of the experimental data is performed within the Michaelis-Menten kinetic mechanism of enzyme catalysis. A simplified version of the MichaelisMenten mechanism containing only four parameters is found to provide a quantitative description of the key features of the experimental data.

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“…The current work applies the bond-deformation concept 18 to rationalize the anomalous behavior of the lifetime of the disulfide bond. 30 The paper is constructed as follows.…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Deformation Model for Thioredoxin Catalysis of Disulfide Bond Dissociation by Force

Pereverzev

Prezhdo

2009

Cel. Mol. Bioeng.

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Modeling cytoadhesion of Plasmodium falciparum‐infected erythrocytes and leukocytes—common principles and distinctive features

et al. 2016

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Cytoadhesion of Plasmodium falciparum‐infected erythrocytes to the microvascular endothelial lining shares striking similarities to cytoadhesion of leukocytes. In both cases, adhesins are presented in structures that raise them above the cell surface. Another similarity is the enhancement of adhesion under physical force (catch bonding). Here, we review recent advances in our understanding of the molecular and biophysical mechanisms underlying cytoadherence in both cellular systems. We describe how imaging, flow chamber experiments, single‐molecule measurements, and computational modeling have been used to decipher the relevant processes. We conclude that although the parasite seems to induce processes that resemble the cytoadherence of leukocytes, the mechanics of erythrocytes is such that the resulting behavior in shear flow is fundamentally different.

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Tailoring the mechanical properties of nanoparticle networks that encompass biomimetic catch bonds

Zhang

Mbanga

Yashin

et al. 2017

J Polym Sci B Polym Phys

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Biological "catch" bonds display the distinctive attribute that the bond lifetime can increase under an applied force. Insertion of biomimetic catch bonds into hybrid materials could lead to composites that exhibit remarkable mechanical properties. We model the tensile behavior of polymergrafted nanoparticle (PGN) networks interconnected by a mixture of catch bonds and conventional "slip" bonds, whose lifetimes decrease with force. We formulate a kinetic master equation that provides the complete probabilistic description of a system of two PGNs. The master equation is used to analyze the parameter space that determines the rupture behavior of the catch bonds in the two-particle system. We then utilize two exemplary sets of catch bond parameters in threedimensional computer simulations of larger PGN networks under strain-controlled tensile deformation. We demonstrate that the strain at break and toughness of the networks can be altered by "tuning" the attributes of the catch bonds and varying the fraction of catch bonds in the network. We show that networks encompassing the catch bonds could exhibit a several-fold increase in the strain-at-break and toughness relative to those interconnected solely by the slip bonds. Our studies can provide valuable guidelines for tailoring the mechanical properties of novel, bio-inspired nanocomposites.

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Force-induced deformations and stability of biological bonds

Cited by 53 publications

References 20 publications

Deformation Model for Thioredoxin Catalysis of Disulfide Bond Dissociation by Force

Deformation Model for Thioredoxin Catalysis of Disulfide Bond Dissociation by Force

Modeling cytoadhesion of Plasmodium falciparum‐infected erythrocytes and leukocytes—common principles and distinctive features

Tailoring the mechanical properties of nanoparticle networks that encompass biomimetic catch bonds

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