Force field particle filter, combining ultrasound standing waves and laminar flow

Hawkes, Jeremy J.; Coakley, W. Terence

doi:10.1016/s0925-4005(01)00553-6

Cited by 208 publications

(126 citation statements)

References 25 publications

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“…While there are various resonant acoustofluidic systems, we investigated here the half-wave resonance in the z-direction, which is a widely used system for particle and cell manipulation. [38][39][40][41][42][43][44][45][46][47] The origin of the coordinates in these models was set at the centre of the fluid channels such that the fluid channels are located within coordinates:…”

Section: Modellingmentioning

confidence: 99%

Modal Rayleigh-like streaming in layered acoustofluidic devices

2016

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Classical Rayleigh streaming is well known and can be modelled using Nyborg’s limiting velocity method as driven by fluid velocities adjacent to the walls parallel to the axis of the main acoustic resonance. We have demonstrated previously the existence and the mechanism of four-quadrant transducer plane streaming patterns in thin-layered acoustofluidic devices which are driven by the limiting velocities on the walls perpendicular to the axis of the main acoustic propagation. We have recently found experimentally that there is a third case which resembles Rayleigh streaming but is a more complex pattern related to three-dimensional cavity modes of an enclosure. This streaming has vortex sizes related to the effective wavelength in each cavity axis of the modes which can be much larger than those found in the one-dimensional case with Rayleigh streaming. We will call this here modal Rayleigh-like streaming and show that it can be important in layered acoustofluidic manipulation devices. This paper seeks to establish the conditions under which each of these is dominant and shows how the limiting velocity field for each relates to different parts of the complex acoustic intensity patterns at the driving boundaries.

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Section: Modellingmentioning

confidence: 99%

Modal Rayleigh-like streaming in layered acoustofluidic devices

2016

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“…For example, focussed ultrasound [2,3] or near-field effects [4] can be used to trap particles prior to analysis, particles can be moved by using two or more opposing transducers to modulate the standing wave field [5,6], or particles can be held and moved within USWs excited by plate waves coupled into the containing fluid [7,8]. However, the use of a simple planar layered resonator with a single transducer [9][10][11] offers the simplest approach to establishing a USW suitable for particle movement.…”

Section: Introductionmentioning

confidence: 99%

Modelling for the robust design of layered resonators for ultrasonic particle manipulation

2008

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a b s t r a c t Several approaches have been described for the manipulation of particles within an ultrasonic field. Of those based on standing waves, devices in which the critical dimension of the resonant chamber is less than a wavelength are particularly well suited to microfluidic, or ''lab on a chip" applications. These might include pre-processing or fractionation of samples prior to analysis, formation of monolayers for cell interaction studies, or the enhancement of biosensor detection capability. The small size of microfluidic resonators typically places tight tolerances on the positioning of the acoustic node, and such systems are required to have high transduction efficiencies, for reasons of power availability and temperature stability. Further, the expense of many microfabrication methods precludes an iterative experimental approach to their development. Hence, the ability to design sub-wavelength resonators that are efficient, robust and have the appropriate acoustic energy distribution is extremely important. This paper discusses one-dimensional modelling used in the design of ultrasonic resonators for particle manipulation and gives example of their uses to predict and explain resonator behaviour. Particular difficulties in designing quarter wave systems are highlighted, and modelling is used to explain observed trends and predict performance of such resonators, including their performance with different coupling layer materials.

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“…The standing wave is maintained by a passive reflecting layer at the far side of the fluid, as shown in Such a resonator may be many wavelengths across, resulting in multiple planes into which cells are gathered [32]. Generally, the fluid layers in the microdevices considered here will be less than a wavelength thick and will gather cells into a single nodal plane [33,34]. An alternative arrangement, the transversal resonator, has been used extensively by Laurell's group in Lund [30,35].…”

Section: Devices For On-chip Ultrasonic Manipulationmentioning

confidence: 99%

Ultrasound assisted particle and cell manipulation on-chip

Mulvana

Cochran

Hill

2013

Advanced Drug Delivery Reviews

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Ultrasonic fields are able to exert forces on cells and other micron-scale particles, including microbubbles. The technology is compatible with existing lab-on-chip techniques and is complementary to many alternative manipulation approaches due to its ability to handle many cells simultaneously over extended length scales. This paper provides an overview of the physical principles underlying ultrasonic manipulation, discusses the biological effects relevant to its use with cells, and describes emerging applications that are of interest in the field of drug development and delivery on-chip.

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Force field particle filter, combining ultrasound standing waves and laminar flow

Cited by 208 publications

References 25 publications

Modal Rayleigh-like streaming in layered acoustofluidic devices

Modal Rayleigh-like streaming in layered acoustofluidic devices

Modelling for the robust design of layered resonators for ultrasonic particle manipulation

Ultrasound assisted particle and cell manipulation on-chip

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