2015
DOI: 10.1007/s00428-015-1758-z
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For early-stage oral tongue cancer, depth of invasion and worst pattern of invasion are the strongest pathological predictors for locoregional recurrence and mortality

Abstract: Despite early diagnosis and treatment, almost 20% of patients with early-stage (cT1-cT2N0) oral tongue squamous cell carcinoma (OTSCC) still die of their disease. The prognosis of OTSCC patients is influenced by several demographic, clinical, and histopathologic factors. The aim of this multicenter international study was to find which of the factors age, gender, stage, grade, lymphocytic host response, perineural invasion, worst pattern of invasion, or depth of invasion has the strongest prognostic power in e… Show more

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Cited by 123 publications
(148 citation statements)
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“…When the tumor depth was between 4-9mm, there was 44% subclinical nodal metastasis, 7% local recurrence and 76% 5 year survival was detected; and they suggested elective neck dissection. Likewise, in another study, high recurrence and metastasis risk was found to be present in tumors with an invasion depth of 4 mm or more 14. In our study, it was found to be statistically significant that ipsilateral metastasis risk increases when tumor depth increased.…”
Section: Discussionsupporting
confidence: 77%
“…When the tumor depth was between 4-9mm, there was 44% subclinical nodal metastasis, 7% local recurrence and 76% 5 year survival was detected; and they suggested elective neck dissection. Likewise, in another study, high recurrence and metastasis risk was found to be present in tumors with an invasion depth of 4 mm or more 14. In our study, it was found to be statistically significant that ipsilateral metastasis risk increases when tumor depth increased.…”
Section: Discussionsupporting
confidence: 77%
“…DOI assesses the invasiveness of a carcinoma regardless of its exophytic component . Its use as a prognostic factor and criterion for neck dissection (ND) in patients with OCSCC has been the topic of multiple clinical analyses, and DOI > 4 mm has been shown to be associated with worse outcomes . However, these studies have been heterogeneous and frequently included patients of any stage and with multiple risk factors for recurrence.…”
Section: Introductionmentioning
confidence: 99%
“…Tongue squamous cell carcinoma (SCC) is the most common malignancy of the oral cavity [2], and nodal metastasis has been reported as one of the prognostic factors for patients with tongue SCC [3].…”
Section: Introductionmentioning
confidence: 99%