Footshock induced analgesia in mice: Its reversal by naloxone and cross tolerance with morphine

Chesner, G.B.; Chan, Ben

doi:10.1016/0024-3205(77)90233-8

Cited by 239 publications

(50 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Akil et al (1) and Chesher and Chan (7) showed that the analgesic effect induced by foot shock stress is antagonized by naloxone, a potent opioid receptor blocker, and suggested the involve ment of the endogenous opioid system in the underlying mechanisms of stress-induced analgesia (SIA). On the other hand, Lal et al (8) described a lack of the antagonistic effect of naloxone on the analgesia induced by forced swimming stress.…”

mentioning

confidence: 99%

Involvement of different mechanisms, opioid and non-opioid forms, in the analgesia induced by footshock (FS) and immobilized-water immersion (IW) stress.

1983

View full text Add to dashboard Cite

mentioning

confidence: 99%

Involvement of different mechanisms, opioid and non-opioid forms, in the analgesia induced by footshock (FS) and immobilized-water immersion (IW) stress.

1983

View full text Add to dashboard Cite

“…However, titration of the dose is critical since it has differing effects at different doses. [21][22][23] The epidural administration of 0.208 ug·kg -1· hr -1 naloxone in our experiment was an effective and safe dose that maintained the analgesic effects of morphine and prevented one of morphine's side-effects -delayed recovery of intestinal motility.…”

Section: Assessment Of Recovery In Intestinal Motilitymentioning

confidence: 63%

Epidural naloxone reduces intestinal hypomotility but not analgesia of epidural morphine

Lee¹,

Shim²,

Choi³

et al. 2001

Can J Anesth/J Can Anesth

View full text Add to dashboard Cite

Purpose: Epidural morphine is associated with decreased bowel motility and increased transit time. Low doses of intravenous naloxone reduce morphine-induced pruritus without reversing analgesia, but the effect of epidural naloxone on bowel motility has not been studied. Therefore we evaluated bowel motility and analgesia when naloxone was co-administered with morphine into the epidural space.Methods: Forty-three patients having combined thoracic epidural and general anesthesia for subtotal gastrectomy were randomly assigned to one of two study groups. All received a bolus dose of 3 mg epidural morphine at the beginning of surgery, followed by a continuous epidural infusion containing 3 mg morphine in 100 ml bupivacaine 0.125% with either no naloxone (control group, n=18) or a calculated dose of 0.208 µg·kg -1 ·hr -1 of naloxone (experimental group, n=25) for 48 hr. We measured the time to the first postoperative passage of flatus and feces to evaluate the restoration of bowel function, and visual analog scales (VAS) for pain during rest and movement. Scores were assessed at 2, 4, 8, 16, 24, 36 and 48 hr postoperatively.Results: The experimental group had a shorter time to the first postoperative passage of flatus (51.9 ± 16.6 hr vs 87.0 ± 19.5 hr, P < 0.001) and feces (95.3 ± 25.0 hr vs 132.9 ± 29.4 hr, P < 0.001). No differences were found in either resting or active VAS between the two groups.Conclusion: Epidural naloxone reduces epidural morphine-induced intestinal hypomotility without reversing its analgesic effects.Objectif : L'administration péridurale de morphine est associée à une baisse de la motilité intestinale et à une augmentation de la durée du transit. De faibles doses de naloxone intraveineuse réduisent le prurit induit par la morphine sans renverser l'analgésie, mais l'effet de l'administration péridurale de naloxone sur la motilité intestinale n'a pas encore été étudié. C'est pourquoi nous avons évalué cette action et l'analgésie de la naloxone administrée avec de la morphine dans l'espace péridural.Méthode : Quarante-trois patients qui recevaient une anesthésie péridurale thoracique et générale combinée, pour une gastrectomie partielle, ont été répartis au hasard en deux groupes. Tous ont reçu un bolus de 3 mg de morphine péridurale au début de l'intervention, suivi d'une perfusion péridurale continue de 3 mg de morphine dans 100 ml de bupivacaïne à 0,125 % sans naloxone (groupe témoin, n=18) ou avec une dose calculée de 0,208 µg·kg -1 ·h -1 de naloxone (groupe expérimental, n=25) pendant 48 h. Nous avons mesuré le temps écoulé avant la première expulsion des gaz intestinaux et des selles afin d'évaluer la restauration de la fonction intestinale et mesuré les scores de douleur à l'aide de l'échelle visuelle analogique (EVA), au repos et pendant le mouvement. Les scores postopératoires ont été relevés à 2, 4, 8, 16, 24, 36 et à 48 h.Résultats : Dans le groupe expérimental, le temps précédant le premier passage postopératoire des gaz (51,9 ± 16,6 h vs 87,0 ± 19,5 h, P < 0,001) et des selles (95,...

show abstract

“…The development of tolerance to an acute dose of morphine I mg kg' (s.c.) was assessed by the phenyl-benzoquinone writhing test in mice. This procedure to develop morphine tolerance is the same as that described by Chescher & Chan (1977). Drugs TRH (Bachem, Budendorf, Switzerland) was dissolved in distilled water or saline for peripheral and central administrations respectively.…”

Section: Study Of Opiate Systems Involvementmentioning

confidence: 99%

Potentiation by TRH of the effect of imipramine on the forced‐swimming test

Reny-Palasse

Rips

1985

British J Pharmacology

View full text Add to dashboard Cite

Footshock induced analgesia in mice: Its reversal by naloxone and cross tolerance with morphine

Cited by 239 publications

References 9 publications

Involvement of different mechanisms, opioid and non-opioid forms, in the analgesia induced by footshock (FS) and immobilized-water immersion (IW) stress.

Involvement of different mechanisms, opioid and non-opioid forms, in the analgesia induced by footshock (FS) and immobilized-water immersion (IW) stress.

Epidural naloxone reduces intestinal hypomotility but not analgesia of epidural morphine

Potentiation by TRH of the effect of imipramine on the forced‐swimming test

Contact Info

Product

Resources

About