Foot shock stress prolongs the telogen stage of the spontaneous hair cycle in a non‐depilated mouse model

Abstract

Background: There is an increasing evidence to indicate that stress can influence skin disease and cutaneous functions. Previous studies have shown that stress alters the murine hair cycle; however, these studies have been carried out by using mouse models in which the hair cycle is forcibly synchronized after depilation. Objective: To examine whether foot shock stress (FS) changes the spontaneous hair cycle in a non‐depilated animal model, and to evaluate the role of mast cells and substance P (SP) in the influence of stress on the hair cycle. Methods: Changes in the spontaneous hair cycle and the inhibitory effects of a specific SP NK1 receptor antagonist were examined in non‐depilated mice during 3–4 weeks of FS. Results: Foot shock stress prolonged the telogen stage of the hair cycle and delayed the induction of the subsequent anagen stage in the animal model. FS caused an increase in the ratio of de‐granulated mast cells in the skin, an increase in the number of TUNEL‐positive cells, and a decrease in the number of Ki67‐positive cells. The NK1 receptor antagonist, WIN 62577, inhibited these stress responses. Conclusion: Our results strongly support previous work, demonstrating that stress alters active hair‐cycling in vivo through the action of SP.

Chaotic Home Climate and Antisocial Behavior among Secondary School Adolescents in Aba Education Zone, Nigeria

“…Obviously, the influence of siblings' rivalry on antisocial behaviour shown in this work could be as a result of the stress and anxiety caused by the prevalence of internecine squabbles between siblings which are usually taken out on peers at school. This agrees with the findings of Keinedy-Moore and Katayama (2007) and Donna (2004) who reported from their separate studies that sibling rivalry often influences the child negatively, causing them to be involved in antisocial behaviour in schools and manifest other social problems. In summary, it is worthy of note that siblings' rivalry which is often dismissed as a normal event in the life of children could result in undesirable social problems and antisocial behaviour.…”

“…By three years old, children have a sophisticated grasp of social rules; can evaluate themselves in relation to their siblings within the family. According to Keinedy-Moore and Katayama (2007), siblings' rivalry often continues throughout childhood and can be very frustrating and stressful to parents and can also influence the children negatively by causing them to be involved in antisocial behaviours in schools.…”

Development of Alopecia Areata Is Associated with Higher Central and Peripheral Hypothalamic–Pituitary–Adrenal Tone in the Skin Graft Induced C3H/HeJ Mouse Model

“…These events may be mediated in part via SP signaling to mast cells and promotion of mast cell degranulation leading to hair follicle regression. Exposure to stress can curtail hair growth in mice with associated increased expression of SP (Arck et al, 2001, 2003; Katayama et al, 2007). In contrast, mice deficient in mast cells, or mast cell-expressed SP receptor NK1R, do not exhibit curtailment of their hair growth cycle in response stress (Arck et al, 2005).…”

Hair and stress: A pilot study of hair and cytokine balance alteration in healthy young women under major exam stress

“…in response to biological stressors such as surgery or acute inflammation [5] but also in monkeys exposed to sever housing stress [66]. In murine synchronized hair growth, psycho-social stress was shown to increase the telogen rate [67] by provoking premature catagen [68], whereby the length of the prematurely induced regression phase and the following telogen was not affected. Catagen in humans lasts for two to three weeks and telogen for approximately 10–12 weeks.…”