Foot-and-mouth disease virus carrier status in Bos grunniens yaks

Chang, Huiyun; Ma, Yuehui; Lin, Tong; Cong, Guozheng; Du, Junzheng; Ma, Jinjin

doi:10.1186/1743-422x-10-81

Cited by 12 publications

(8 citation statements)

References 33 publications

(31 reference statements)

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“…Furthermore, in the same model, further studies showed that persistent FMDV evolves to induce a more intense shut-off of host-cell protein expression [24]. Viral mutations of FMDV during persistence, leading to antigenic variation, have been proposed to be among the key factors in the establishment and maintenance of persistence of infection in vivo [11,16,20,36]. Interestingly, sequencing the VP1 coding region of virus isolated from persistently infected cattle or water buffalo reveals modifications of only 2 to 6 amino acids, targeting mostly residues 40-50 and 135-151 [7,20].…”

Section: Discussionmentioning

confidence: 93%

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Establishment of persistent foot-and-mouth disease virus (FMDV) infection in MDBK cells

et al. 2015

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In addition to acute infection and disease, foot-and-mouth disease virus (FMDV) can cause persistent infection in ruminants. Such "carrier" animals represent a potential risk for FMDV transmission to susceptible animals. However, the mechanisms and the factors that determine FMDV persistence remain unknown. We describe here the establishment of FMDV type O persistent infection in a bovine epithelial cell line (Madin-Darby bovine kidney; MDBK). Preliminary experiments to assess the permissivity of MDBK cells to FMDV O infection revealed an unusual pattern of infection: after the initial phase of acute cell lysis, new monolayers formed within 48-72 h post-infection. We found that some cells survived cytolytic infection and subsequently regrew, thereby demonstrating that this bovine cell line can be persistently infected with FMDV type O. Further evidence that MDBK cells were persistently infected with FMDV includes: (i) detection of viral RNA in cells as well as in cell culture supernatants, (ii) detection of viral antigens in the cells by immunofluorescence analysis, and (iii) production of infectious viral particles for up to 36 cell passages. Furthermore, preliminary sequence analysis of persistent virus revealed a single nucleotide substitution within the VP1 coding region, resulting in the V50A amino acid substitution. This bovine model of FMDV persistence holds promise for the investigation of the viral and cellular molecular determinants that promote FMDV persistence.

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Section: Discussionmentioning

confidence: 93%

“…The FMDV carrier state has been clearly demonstrated in ruminants, particularly in bovine species (wild as well as domestic) [2,11,33,50]. We therefore sought to develop an in vitro model to study cellular and/or viral determinants of FMDV persistence, using a bovine epithelial cell line, the Madin-Darby bovine kidney (MDBK) cell line.…”

Section: Introductionmentioning

confidence: 99%

Establishment of persistent foot-and-mouth disease virus (FMDV) infection in MDBK cells

et al. 2015

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“…Most cattle carry foot-and-mouth disease virus (FMDV) for six months or less, but some animals can remain persistently infected for up to 3.5 years [ 4 , 5 ]. The virus or its nucleic acids have been found for up to 12 months in sheep, up to 4 months in goats, for a year in water buffalo, and up to 8 months in yaks [ 7 ]. Carrier animals can only be identified by collecting esophageal-pharyngeal fluids for virus isolation and/or the detection of nucleic acids.…”

Section: Introductionmentioning

confidence: 99%

Modeling the Effects of Multiple Intervention Strategies on Controlling Foot-and-Mouth Disease

Mushayabasa

Tapedzesa

2015

BioMed Research International

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Foot-and-mouth disease (FMD) is a threat to economic security and infrastructure as well as animal health, in both developed and developing countries. We propose and analyze an optimal control problem where the control system is a mathematical model for FMD that incorporates vaccination and culling of infectious animals. The control functions represent the fraction of animals that are vaccinated during an outbreak, infectious symptomatic animals that are detected and culled, and infectious nonsymptomatic animals that are detected and culled. Our aim was to study how these control measures should be implemented for a certain time period, in order to reduce or eliminate FMD in the community, while minimizing the interventions implementation costs. A cost-effectiveness analysis is carried out, to compare the application of each one of the control measures, separately or in combination.

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“…Self-recovery is the result of immunity against the serotype of the virus. Mostly, FMD occurs due to one type of virus and immunity remain limited against specific serotype, thus no immunity develops against another serotypes, so in endemic areas, it is the main reason behind occurrence of disease[31]. In most extreme cases, mortality in lambs and suckling pigs ranges from 20-75% and it depends on age.…”

mentioning

confidence: 99%

A review on foot and mouth disease in dairy animals, etiology, pathogenesis and clinical findings

Azeem¹

2020

PAB

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Foot-and-mouth disease (FMD) is an extremely contagious disease of angulated animals and in livestock, it is an important pathogen more than 120 years after it was recognized. The virus of this disease belong to a genus Aphthovirus of the family picornaviridae and present as seven serotypes C, O, A, SAT1, SAT2, SAT3, and Asia1. Transmission of this disease occurs by direct and indirect contact, ingestion and by aerosols. The best multiplication sites of this virus are oral cavity, udder, heart, feet, and oro-pharynx. Specific, sensitive and quick diagnostic tools are required for effective control of this disease. FMD causes fever, salivation, anorexia and vesicular eruption on teats, feet, and mouth. In FMDV (Foot and Mouth disease Virus) endemic areas, annual production losses and vaccination estimated US$6.5-US$21 billion. Currently, the techniques which are used for diagnosis of FMD are Sandwich-ELISA (S-ELISA), Virus Isolation (VI), indirect ELISA (DIVA), real time-PCR and Liquid-Phase Blocking ELISA (LPBE) can be used for recognition of antibody against nonstructural proteins. The techniques which are used for quick and specific detection of FMDV are microarray and recombinant antigen-based detection, biosensor, Nucleotide sequencing, phage display and nucleic-acid-based diagnostic for serotyping. This review provides information about the FMD in Pakistan as many cases are reported in Pakistan and lead to morbidity and mortality of many animals. This review helps the reader to handle the cases practically in the field and helps the researchers to analyze the comprehensive picture of the FMD and in future researchers try to minimize such cases after reading this in Pakistan.

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Foot-and-mouth disease virus carrier status in Bos grunniens yaks

Cited by 12 publications

References 33 publications

Establishment of persistent foot-and-mouth disease virus (FMDV) infection in MDBK cells

Establishment of persistent foot-and-mouth disease virus (FMDV) infection in MDBK cells

Modeling the Effects of Multiple Intervention Strategies on Controlling Foot-and-Mouth Disease

A review on foot and mouth disease in dairy animals, etiology, pathogenesis and clinical findings

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