Foot-and-mouth disease vaccine potency testing in cattle using homologous and heterologous challenge strains: Precision of the “Protection against Podal Generalisation” test

Goris, Nesya; Maradei, Eduardo; D’Aloia, Ricardo; Fondevila, Norberto; Mattion, Nora; Pérez, Andrés; Smitsaart, Eliana; Nauwynck, Hans; Torre, J.L. La; Palma, Eduardo L.; Clercq, Kris De

doi:10.1016/j.vaccine.2008.04.034

Cited by 37 publications

(37 citation statements)

References 24 publications

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“…It has been reported that this indirect potency measurement is at least as precise as the in vivo challenge test, and can be standardized to 'antigen PD 50 ' values [31]. Development of such an assay system need to be done in the country in order to avoid animal ethics problem, biosecurity and biosafety concerns, and problem in the disposal of infected cattle when challenge method is used for potency testing of the vaccine.…”

Section: Vaccine and Vaccinationmentioning

confidence: 99%

Foot-and-mouth Disease: Global Status and Future Road Map for Control and Prevention in India

et al. 2012

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Foot-and-mouth disease (FMD) is a transboundary, economically devastating and highly contagious viral disease of livestock, most importantly cattle, buffalo and pig. The disease also affects goats, sheep, wild ruminant species and elephants. The causative FMD virus is antigenically diverse having seven distinct serotypes and many variants within them. Being a single stranded RNA virus, it confirms the quasispecies nature with emergences and reemergences of different genetic lineages with altered antigenicity within the serotypes, making vaccination based control programme a high cost effective, time consuming and difficult to achieve. As per the OIE and FAO, the disease is a major threat to food security of the world, and particularly the countries having the disease are more prone to food insecurity. Further, FMD free status is an indicator of development, and all developed countries are free from it. The disease is endemic in India and three serotypes of the virus viz; O, A and Asia1 are circulating. Annual direct loss due to FMD in India has been estimated at Rs. 20,000 crores. Many countries in the world are now free from FMD with or without vaccination and presence of the disease in other neighboring countries is a major threat to them. Countries having FMD face trade barrier posed by FMD free countries, causing heavy economic loss to the livestock industry. Progressive control pathway has been developed by FAO for global eradication of FMD. Vaccination based FMD control programme is in operation in India which involves biannual vaccinations of all cattle and buffaloes in selected areas, regular active surveillance and antibody monitoring in vaccinated population with the objective of creating FMD free zones. At present, the disease occurrence, severity of the clinical disease and number of outbreaks have progressively and substantially declined in the control zones as a result of last 10 rounds of vaccination with an oil adjuvanted trivalent inactivated vaccine. In this review, FMD scenario in India and in the world is briefed. Besides, the measures taken for the control and eradication of this devastating disease is presented. Besides, the initial success achieved through the FMD control programme in India, a road map for the control and eradication of FMD at national level is discussed.

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Section: Vaccine and Vaccinationmentioning

confidence: 99%

Foot-and-mouth Disease: Global Status and Future Road Map for Control and Prevention in India

et al. 2012

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“…Vaccine efficacy as well as surveillance of vaccine immunity is performed by serology. Strain-specific antibody titers obtained with liquid phase blocking ELISA (LPBE) have been statistically correlated to in vivo protection to assess vaccine potency and herd immunity through the estimation of a percentage of expected protection (EPP) [8][9][10][11][12].…”

Section: Introductionmentioning

confidence: 99%

Simultaneous immunization of cattle with foot-and-mouth disease (FMD) and live anthrax vaccines do not interfere with FMD booster responses

Trotta¹,

Lahore

Cardoso³

et al. 2015

Trials in Vaccinology

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a b s t r a c tFoot-and-mouth disease (FMD) vaccination in Argentina is compulsory for most of the cattle population and conducted by certified veterinarians. This organized campaign may facilitate the controlled application of other vaccines against endemic diseases, provided immune responses against FMD are not hindered. There is no published information on the interference of immunity against FMD vaccines when applied together with a live bacterial vaccine. In this study we evaluated if the simultaneous application of a Bacillus anthracis live vaccine with a commercial tetravalent oil-based FMD vaccine (FMD-vac) used in Argentina, modifies the antibody booster responses against FMD virus (FMDV) in cattle. Two groups of 16 heifers with comparable liquid phase blocking ELISA (LPBE) titers were immunized with the FMD-vac alone or simultaneously with a commercial attenuated bovine anthrax Sterne strain vaccine (ABV). Serum samples were obtained at 0, 25, 60 and 90 days post vaccination (dpv) and specific antibodies against two FMDV vaccine strains were assessed by LPBE, avidity and IgG-isotype ELISAs. Bovines immunized with FMD-vac or FMDV-V + ABV responded with a boost in the LPBE antibody titers and avidity at 25 dpv, and remained within similar levels up to the end of the study. Animals vaccinated with FMD-vac + ABV had significantly higher LPBE titers at 25 dpv, compared to those immunized with FMD-vac alone; which was due to an increase in IgG2 titers. Overall, antibody titers elicited in both groups were similar and followed comparable kinetics over time. We conclude that the simultaneous application of a live anthrax vaccine with the current FMD tetravalent vaccine used in Argentina in cattle previously immunized against FMD, did not counteract the serological response induced by FMD vaccination.

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“…However, many studies have discussed alternative FMD vaccine potency tests that are amenable from an animal welfare perspective and show better statistical reliability (1,2,9,23). In this regard, the RP ELISA could be employed as a simple and reliable assay to replace the LPB ELISA or the VNT.…”

mentioning

confidence: 99%

Use of a Baculovirus-Expressed Structural Protein for the Detection of Antibodies to Foot-and-Mouth Disease Virus Type A by a Blocking Enzyme-Linked Immunosorbent Assay

Lee

Jeoung

et al. 2010

Clin Vaccine Immunol

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A blocking enzyme-linked immunosorbent assay (ELISA) with a baculovirus-expressed structural protein was developed for the detection of antibodies to foot-and-mouth disease virus type A. It exhibited 99% specificity with a cutoff of 53% inhibition. Its sensitivity was comparable to the sensitivities of the virus neutralization test and the liquid-phase blocking ELISA, indicating its potential as an alternative assay.

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Foot-and-mouth disease vaccine potency testing in cattle using homologous and heterologous challenge strains: Precision of the “Protection against Podal Generalisation” test

Cited by 37 publications

References 24 publications

Foot-and-mouth Disease: Global Status and Future Road Map for Control and Prevention in India

Foot-and-mouth Disease: Global Status and Future Road Map for Control and Prevention in India

Simultaneous immunization of cattle with foot-and-mouth disease (FMD) and live anthrax vaccines do not interfere with FMD booster responses

Use of a Baculovirus-Expressed Structural Protein for the Detection of Antibodies to Foot-and-Mouth Disease Virus Type A by a Blocking Enzyme-Linked Immunosorbent Assay

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