Editorial on the Research Topic Advancements in biomechanical modeling of injuries, diseases, diagnoses, and treatments of lower extremitiesThe musculoskeletal system is a complex multi-articular structure which provides a relative range of motion for functional activities. It seems similarities between the joint biomechanics of the upper and the lower extremities. However, the upper extremity is more specialized for daily activities with greater ranges of motion, and the lower extremity structures are well prepared for locomotion and its weight-bearing (Yan et al., 2015). The basic principles of lower limb biomechanics focus on understanding the mechanical response and performance, the effect of injuries or diseases, and movement optimization in hope of finding effective rehabilitation procedures. Nevertheless, there is still a lack of knowledge in this research field, particularly at the level of injury risk factors, muscle functions, control, and instability. Hence, studying the biomechanical response of healthy, diseased, and treated lower extremities has been of great interest to clinicians and researchers. Numerous experimental, theoretical, as well as computational biomechanical studies have been conducted in the hope of understanding the underlying mechanisms involved in lower limb biomechanics. While some studies have been geared toward the prevention of injuries, others deal with more effective diagnostic and treatment modalities. Experimental clinical studies, using both in-vitro and in-vivo platforms, have the ability to provide relevant information regarding the biomechanical behavior and response of the lower extremities. Incidentally, these studies are essential but could be costly and limited by their inability to estimate the detailed microstructural phenomenon.In the past few decades, different mathematical and computational methodologies of modeling [such as musculoskeletal and finite element (FE) modeling] have emerged as powerful and practical tools for non-invasive biomechanical investigations. These modeling approaches can explore the various aspects of the lower extremities, from the response of the