Foodborne illness caused by muscarine-containing mushrooms and identification of mushroom remnants using phylogenetics and LC-MS/MS

Parnmen, Sittiporn; Nooron, Nattakarn; Leudang, Siriwan; Sikaphan, Sujitra; Polputpisatkul, Dutsadee; Pringsulaka, Onanong; Binchai, Sutheewan; Rangsiruji, Achariya

doi:10.1016/j.foodcont.2021.108182

Cited by 15 publications

(21 citation statements)

References 30 publications

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“…The species diversity of Inocybaceae was documented by a series of studies in China (Fan and Bau, 2010 , 2013 , 2014a , b , 2016 , 2017 , 2018 , 2020 ; Bau and Fan, 2018 ; Fan et al, 2018 ; Yu et al, 2020 ; Deng et al, 2021a , b ; Li et al, 2021b ). Inosperma genus only includes a few toxic species, but a high level of muscarine was frequently detected (Kosentka et al, 2013 ; Sailatha et al, 2014 ; Latha et al, 2020 ; Deng et al, 2021a ; Patocka et al, 2021 ) and was reported constantly in mushroom poisoning incidents from tropical Asia (Chandrasekharan et al, 2020 ; Parnmen et al, 2021 ; Li et al, 2022 ).…”

Section: Introductionmentioning

confidence: 99%

A New Muscarine-Containing Inosperma (Inocybaceae, Agaricales) Species Discovered From One Poisoning Incident Occurring in Tropical China

Deng

Zeng

et al. 2022

Front. Microbiol.

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Currently, mushroom poisoning still poses a huge problem to humans' health and life globally. Poisoning incidents caused by Inosperma spp. were reported continuously in tropical China in recent years. In this study, a new poisonous Inosperma species, discovered from a poisoning incident, was described in tropical China based on morphological, molecular, and toxin detection evidence; detailed descriptions, photographs, and comparisons to closely related species were provided. For qualitative analysis, through targeted screening using ultra-high liquid chromatography triple quadrupole mass spectrometry (UPLC-MS/MS), the new species contains muscarine and no other toxins (two isoxazole derivatives, two tryptamine alkaloids, three amatoxins, and three phallotoxins). For quantitative analysis, muscarine contents in the pileus and the stipe were 2.08 ± 0.05 and 6.53 ± 1.88 g/kg, respectively.

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Section: Introductionmentioning

confidence: 99%

A New Muscarine-Containing Inosperma (Inocybaceae, Agaricales) Species Discovered From One Poisoning Incident Occurring in Tropical China

Deng

Zeng

et al. 2022

Front. Microbiol.

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“…This compound is unable to cross the blood-brain and blood-cerebrospinal fluid barriers, preventing potential effects on the acetylcholine receptors of the central nervous system. Although it is present as trace amounts (0.02% dry weight) in the basidiocarps, muscarine is notably responsible for the autonomic aspects of the symptoms-and, particularly, the gastrointestinal ones-upon mushroom consumption, involving perspiration, hypersalivation, lachrymation, bradycardia, diarrhea, and fatigue [36,37]. Higher concentrations of muscarine are reported in mushrooms belonging to the genera Inocybe, Inosperma and Pseudosperma [37].…”

Section: Muscarinementioning

confidence: 99%

Amanita muscaria: Ecology, Chemistry, Myths

Carboué

Lopez

2021

Encyclopedia

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Amanita muscaria is the most emblematic mushroom in the popular representation. It is an ectomycorrhizal fungus endemic to the cold ecosystems of the northern hemisphere. The basidiocarp contains isoxazoles compounds that have specific actions on the central nervous system, including hallucinations. For this reason, it is considered an important entheogenic mushroom in different cultures whose remnants are still visible in some modern-day European traditions. In Siberian civilizations, it has been consumed for religious and recreational purposes for millennia, as it was the only inebriant in this region.

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“…According to the classification of mushroom toxicity by White et al 6 , these mushrooms cause five major types of toxicity, including cytotoxicity ( A. brunneitoxicaria , D346), neurotoxicity ( Pseudosperma sp., D523), myotoxicity ( R. subnigricans , D338), metabolic/endocrine toxicity ( C. virosa , D287), gastrointestinal toxicity ( C. molybdites , D392), and gastrointestinal toxicity coupled with neurotoxicity ( E. mastoideum , D322 ) . Although ingestion of most of these mushrooms resulted in mild poisoning symptoms 4 , 5 , 7 , A. brunneitoxicaria and R. subnigricans caused fatal mushroom poisoning 1 , 3 .…”

Section: Introductionmentioning

confidence: 99%

“…However, due to their morphological resemblance, poisonous mushrooms are often misidentified as edible species. Unintentional ingestion of toxic mushrooms can result in adverse poisoning effects, ranging from mild gastrointestinal symptoms to severe cytotoxic effects and death of patients [1][2][3][4][5]. Gastrointestinal irritant mushroom poisoning was most commonly encountered, followed by neurotoxic, cytotoxic, myotoxic and metabolic/endocrine toxicity mushroom poisoning [1].…”

Section: Introductionmentioning

confidence: 99%

Draft Genomes of Six Wild Poisonous Mushrooms

Parnmen¹,

Nooron²,

Sikaphan³

et al. 2022

J. Genomics

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Foodborne illnesses caused by wild mushroom poisoning occur globally and have led to food safety concerns. Here, we reported de novo genome assemblies of the six most commonly encountered toxic mushrooms in Thailand. These comprised Amanita brunneitoxicaria , Cantharocybe virosa , Chlorophyllum molybdites , Entoloma mastoideum , Pseudosperma sp. and Russula subnigricans . The nuclear genome sizes of these species ranged from 40 to 77 Mb, with the number of predicted genes ranging from 5,375 to 14,099. The mitogenome sizes varied from 41,555 to 78,907 bp. The resulting draft genomes of these poisonous mushrooms provide insights into toxin-related genes that may be used to establish genetic markers for monitoring mushroom poisoning outbreaks.

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Foodborne illness caused by muscarine-containing mushrooms and identification of mushroom remnants using phylogenetics and LC-MS/MS

Cited by 15 publications

References 30 publications

A New Muscarine-Containing Inosperma (Inocybaceae, Agaricales) Species Discovered From One Poisoning Incident Occurring in Tropical China

A New Muscarine-Containing Inosperma (Inocybaceae, Agaricales) Species Discovered From One Poisoning Incident Occurring in Tropical China

Amanita muscaria: Ecology, Chemistry, Myths

Draft Genomes of Six Wild Poisonous Mushrooms

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