Food web biomagnification of the neurotoxin β-N-methylamino-L-alanine in a diatom-dominated marine ecosystem in China

Wang, Chao; Chen, Yan; Qiu, Jiangbing; Liu, Chao; Yan, Yeju; Ji, Ying; Wang, Guixiang; Chen, Hongju; Li, Yang; Li, Aifeng

doi:10.1016/j.jhazmat.2020.124217

Cited by 27 publications

(12 citation statements)

References 60 publications

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“…The absence of bacteria producing β- N -methylamino- l -alanine in the gut of gastropod Nevertia didyma suggests detection of the neurotoxin in the mollusc is evidence of trophic transfer. 360 A comparison of 313 polar metabolites within 21 phytoplankton species has shown that the bulk community metabolome is reflective of the producing algal community. These results show that the algal community composition can have a large effect on the carbon economy of the local ocean surface.…”

Section: Marine Microorganisms and Phytoplanktonmentioning

confidence: 99%

Marine natural products

et al. 2023

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Section: Marine Microorganisms and Phytoplanktonmentioning

confidence: 99%

Marine natural products

et al. 2023

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“…In addition to cyanobacteria, several diatoms species produce BMAA and its structural isomers [16][17][18]. Several of these potential BMAA-producers are present in our study area, the coast of Galicia in North-West (NW) Spain (Figure 1), i.e.,the diatoms Chaetoceros spp., Navicula spp., Skeletonema spp., and Thalassiosira spp.…”

Section: Introductionmentioning

confidence: 97%

No β-N-Methylamino-L-alanine (BMAA) Was Detected in Stranded Cetaceans from Galicia (North-West Spain)

Soliño

Kim

López

et al. 2022

JMSE

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The neurotoxin β-N-methylamino-L-alanine (BMAA), a non-proteinogenic amino acid produced by several species of both prokaryotic (cyanobacteria) and eukaryotic (diatoms) microorganisms, has been proposed to be associated with the development of neurodegenerative diseases. At first, BMAA appeared to be ubiquitously present worldwide in various organisms, from aquatic and terrestrial food webs. However, recent studies, using detection methods based on mass spectrometry, instead of fluorescence detection, suggest that the trophic transfer of BMAA is debatable. This study evaluated BMAA in 22 cetaceans of three different species (Phocoena phocoena, n = 8, Delphinus delphis, n = 8, and Tursiops truncatus, n = 6), found stranded in North-West Spain. BMAA analysis of the liver, kidney, or muscle tissues via sensitive liquid chromatography with tandem mass spectrometry did not reveal the presence of this compound or its isomers. The absence recorded in this study highlights the need to better understand the trophic transfer of BMAA and its anatomical distribution in marine mammals.

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“…The total amount of BMAA increases from 0.3 μg/g in cyanobacteria, to 1160 μg/g in cycad seeds, and further to 3560 μg/g in the Micronesian flying fox Pteropus mariannus , which is considered a delicacy food by the locals [ 5 ]. It is considered that diatom algae, dinoflagellates and even plants can also synthesize and accumulate BMAA [ 2 , 6 , 7 , 8 ]. Therefore, the accumulation of toxic doses of BMAA in humans from aquatic [ 9 , 10 ] and other food sources is quite probable, at least for some areas and seasons.…”

Section: Introductionmentioning

confidence: 99%

β-N-Methylamino-L-Alanine (BMAA) Modulates the Sympathetic Regulation and Homeostasis of Polyamines

Shkodrova

Mishonova

Chichova

et al. 2023

Toxins

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The neurotoxin β-N-methylamino-L-alanine (BMAA) is a non-proteinogenic amino acid produced by cyanobacteria. Non-neuronal toxicity of BMAA is poorly studied with a reported increase in reactive oxygen species and a decrease in the antioxidant capacity of liver, kidney, and colorectal adenocarcinoma cells. The aim of this research is to study the toxicity of BMAA (0.1–1 mM) on mitochondria and submitochondrial particles with ATPase activity, on the semicarbazide-sensitive amino oxidases (SSAOs) activity of rat liver, and on an in vitro model containing functionally active excitable tissues—regularly contracting heart muscle preparation with a preserved autonomic innervation. For the first time the BMAA-dependent inhibition of SSAO activity, the elimination of the positive inotropic effect of adrenergic innervation, and the direct and reversible inhibition of adrenaline signaling in ventricular myocytes with 1 mM BMAA were observed. Additionally, it is confirmed that 1 mM BMAA can activate mitochondrial ATPase indirectly. It is concluded that a higher dose of BMAA may influence multiple physiological and pathological processes as it slows down the degradation of biogenic amines, downregulates the sympathetic neuromediation, and embarrasses the cell signaling of adrenergic receptors.

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Food web biomagnification of the neurotoxin β-N-methylamino-L-alanine in a diatom-dominated marine ecosystem in China

Cited by 27 publications

References 60 publications

Marine natural products

Marine natural products

No β-N-Methylamino-L-alanine (BMAA) Was Detected in Stranded Cetaceans from Galicia (North-West Spain)

β-N-Methylamino-L-Alanine (BMAA) Modulates the Sympathetic Regulation and Homeostasis of Polyamines

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