Food supplements could be an effective improvement of diabetes mellitus: a review

Meng, Xiangxi; Li, Qinyu; Shi, Ruyu; Chang, Jiayin; Chang, Hong; Li, Min-Hui

doi:10.1016/j.jfutfo.2021.09.003

Cited by 19 publications

(9 citation statements)

References 107 publications

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“…Plants have long been thought to be the foundation of nutrient-dense and useful diets, as well as the source of modern medicines throughout human history, which is not only because of their easy availability and low cost, but also because they are believed to have less harmful effects than synthetic drugs ( 37 , 38 ). In addition, when used in combination with different conventional chemotherapy drugs, they produce synergistic effects, thereby reducing the dose of drugs used at the same time, optimizing efficacy and toxicity, and may overcome the problem of drug resistance ( 39 ). Therefore, it has a greater margin of safety and praiseworthy efficacy for a variety of diseases, and can be evaluated in clinical trials in a variety of cases ( 40 , 41 ).…”

Section: Discussionmentioning

confidence: 99%

The Immunomodulatory Effects of Active Ingredients From Nigella sativa in RAW264.7 Cells Through NF-κB/MAPK Signaling Pathways

et al. 2022

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Nigella sativa is a valuable herb for its functional compositions in both food and medication. N. sativa seeds can enhance immunity, anti-inflammation and analgesia and hypoglycemia, but most of the related researches are related to volatile oil and extracts, and the activity and mechanism of compounds is not clear. In this study, Ethyl-α-D-galactopyranoside (EG), Methyl-α-D-glucoside (MG), 3-O-[β-D-xylopyranose-(1 → 3)-α-L-rhamnose-(1 → 2)-α-L-arabinose]-28-O-[α-L-rhamnose-(1 → 4)-β-D-glucopyranose-L-(1 → 6)-β-D-glucopyranose]-hederagenin (HXRARG) and 3-O-[β-D-xylopyranose-(1 → 3)-α-L-rhamnose-(1 → 2)-α-L-arabinose]-hederagenin (HXRA) were isolated and identified from N. sativa seeds. In addition, four compounds could activate NF-κB pathway by promoting the expression of phosphorylation of P65 and IκBα, promoting the phosphorylation of JNK, Erk and P38 to activate MAPK signaling pathway, enhancing the proliferation and phagocytic activity of RAW264.7 cells, and promoting the release of NO, TNF-α and IL-6 on RAW264.7 cell in vitro. The results showed that N. sativa can be used as dietary supplement to enhance immune.

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Section: Discussionmentioning

confidence: 99%

The Immunomodulatory Effects of Active Ingredients From Nigella sativa in RAW264.7 Cells Through NF-κB/MAPK Signaling Pathways

et al. 2022

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“…The approximated rise in diabetic people would be 578 and 700 million people by 2030 and 2045 respectively (Saeedi et al, 2019). It is mainly caused by improper insulin secretion and functioning and triggered by genetic, lifestyle, and environmental factors (Meng et al, 2021). In diabetes, it becomes crucial to understand the integrated physiological mechanism of insulin resistance and β‐cell dysfunction which regulate the glucose uptake in muscles leading to type 1 and 2 diabetes.…”

Section: Diabetesmentioning

confidence: 99%

Diosgenin: An ingress towards solving puzzle for diabetes treatment

Arya

Kumar

2022

Journal of Food Biochemistry

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The consumption and composition of food in daily life predict our health in long run. The relation of diabetes to sweets is quite popular. Diabetes hampers the glucose and insulin regulation in the human body by damaging pancreatic β cells. Diabetes has a strong potential towards altering cellular mechanisms of organs causing unlawful performance. Diabetes alters pathways like TLR4, AChE, NF‐ĸB, LPL, and PPAR at different sites that affect the normal cellular machinery and cause damage to the local tissue and organ. The long‐lasting effect of diabetes was observed in vascular, cardia, nervous, skeletal, reproductive, hepatic, ocular, and renal systems. The increasing awareness of diabetes and its concern has awakened the common people more enthusiastically. Due to rising harm from diabetes, scientific researchers tend to have more eyes toward it. While searching for diabetes solutions, fenugreek diosgenin could pop up with some positive effects in curing the same. Diosgenin helps to lower the scathe of diabetes by modifying cellular pathways in favor of healthy bodily functions. Diosgenin altered the pathways for renewal of pancreatic β cells for better insulin secretion, initiate GLUT4, enhanced DHEA, modify ER‐α‐mediated PI3K/Akt pathways. Diosgenin can be an appropriate insult for diabetes in a much evolving way for a healthy lifestyle. Practical applications Diabetes is one of the most death causing diseases in the medical world. Regrettably the cure of diabetes is yet to be found. Various scientific team working on the same to look after the most appropriate way for diabetes treatment. There is enormous growth of nutraceutical in the market claiming for cure of different metabolic disorders. Among various bioactive compound fenugreek's diosgenin could took a leap over other in curing and preventing the damage caused by diabetes to different organs. The role of diosgenin in curing various metabolic disorders is quite popular from some time. This article also emphasizes over beneficiary effect of diosgenin in curing the damages caused by diabetes by altering cellular metabolism processes. Hence diosgenin could be a better way for researchers to develop a method for diabetes treatment.

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“…Iridoids, as the main chemical constituents of P. scabiosaefolia, exhibit various biological activities, such as antiinflammatory, antioxidant, and antitumor [32][33][34][35][36][37][38]. Furthermore, an increasing number of studies have shown that iridoids can improve T2DM through multiple ways [39]. Catalpa, a bioactive ingredient in Zantedeschia rehmannii root, can not only improve liver insulin resistance by acting on AMPK/NOX4/PI-3 K/AKT pathways [7] but also improve HFD-induced insulin resistance in mice by reducing adipose tissue inflammation and inhibiting JNK and NF-κB pathways [40].…”

Section: Discussionmentioning

confidence: 99%

Patrinoside and Patrinoside A from Patrinia scabiosaefolia Improve Insulin Resistance by Inhibiting NF-κB, MAPK Pathways and Oxidative Stress in RAW264.7 and 3 T3-L1 Cells

Liu

Wang

Liu

et al. 2023

Oxidative Medicine and Cellular Longevity

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Patrinia scabiosaefolia, as traditional food and medicine plant, was used to treat appendicitis, enteritis, and hepatitis for thousand years in China. Patrinoside and patrinoside A isolated from P. scabiosaefolia could significantly improve insulin resistance (IR) by activating PI-3 K/AKT signaling pathway in our previous study. Since IR is closely related to inflammation, their anti-inflammatory activities in RAW264.7 inflammatory model induced by LPS and in 3 T3-L1 IR inflammatory model induced by TNF-α were evaluated to identify whether the effects on improving IR related to anti-inflammatory activity. In RAW264.7 cells, patrinoside and patrinoside A significantly inhibited the transcription and secretion of inflammatory mediators NO, TNF-α, and IL-6. Western blot analysis showed that the significant inhibition of phosphorylation of IκB and P65 and P38, ERK and JNK suggested that the effects were exerted through NF-κB pathway and MAPK pathway. In 3 T3-L1 cells, patrinoside and patrinoside A also inhibited the activation of NF-κB and MAPK pathways through inhibiting the transcriptions of inflammatory cytokines IL-6 and chemokines MCP-1 and MIP-1α. These events resulted in the inhibition of macrophages migration to adipocytes. In addition, patrinoside and patrinoside A ameliorated oxidative stress by inhibiting ROS release in LPS-stimulated RAW264.7 cells. In conclusion, patrinoside and patrinoside A could active PI-3 K/AKT pathway, inhibit NF-κB pathway, MAPK pathway, and improve oxidative stress, which showed multipathways on improving IR. These results provided the scientific basis for material basis and mechanism on improving IR of P. scabiosaefolia.

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Food supplements could be an effective improvement of diabetes mellitus: a review

Cited by 19 publications

References 107 publications

The Immunomodulatory Effects of Active Ingredients From Nigella sativa in RAW264.7 Cells Through NF-κB/MAPK Signaling Pathways

The Immunomodulatory Effects of Active Ingredients From Nigella sativa in RAW264.7 Cells Through NF-κB/MAPK Signaling Pathways

Diosgenin: An ingress towards solving puzzle for diabetes treatment

Patrinoside and Patrinoside A from Patrinia scabiosaefolia Improve Insulin Resistance by Inhibiting NF-κB, MAPK Pathways and Oxidative Stress in RAW264.7 and 3 T3-L1 Cells

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