Food supplementation among HIV-infected adults in Sub-Saharan Africa: impact on treatment adherence and weight gain

Audain, Keiron; Zotor, Francis; Amuna, Paul; Ellahi, Basma

doi:10.1017/s0029665115000063

Cited by 25 publications

(24 citation statements)

References 42 publications

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“…Absence of nutritional support fuels the synergistic co-existence of HIV and malnutrition that has a perverse effect on ART adherence and the wellbeing of PLWHA (Mekuria et al, 2015;Sicotte et al, 2014;Berhe, Tegabu & Alemayehu, 2013). Therefore, nutritious food support is highly regarded as a viable option to increase weight gain (Audain et al, 2015) and improve treatment outcome (Chaiyachati et al, 2014;Tiyou et al, 2012).…”

Section: Discussionmentioning

confidence: 99%

Magnitude of non-adherence to antiretroviral therapy and associated factors among adult people living with HIV/AIDS in Benishangul-Gumuz Regional State, Ethiopia

Nigusso

Mavhandu-Mudzusi

2020

PeerJ

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Introduction Following global efforts to increase antiretroviral therapy (ART) access and coverage, Ethiopia has made significant achievement with a 6.3% annual decline in the HIV/AIDS incidence rate between 1990 and 2016. Such success depends not only on access to ART but also on attaining optimum treatment adherence. Emerging studies in Ethiopia has shown the increasing prevalence of poor adherence and lack of the desired viral suppression, but the extent and factors associated with non-adherence to ART are not well known, especially in the current study setup. In this study, we examined the magnitude and factors associated with treatment and non-adherence to ART among people living with HIV in Benishangul-Gumuz Regional State, northwest Ethiopia. Methods An institutional facility based cross-sectional descriptive study was carried out among adult people living with HIV/AIDS from mid-December 2016 to February 2017 with only 98.9% response rate. Sociodemographic factors (age, gender, marital status and residential area), economic factors (educational status, income, asset possession, employment status, dietary diversity, nutritional status and food security), and clinical characteristics (CD4 count, duration on ART and history of opportunistic infections) were explanatory variables. ART non-adherence was measured using a visual analogue scale (VAS). We used binary logistic regression and subsequent multivariate logistic regression analysis to determine the factors associated with ART non-adherence. Result Overall, 39.7% of the participants were found non-adherent to ART. Strong association was found between non-adherence to ART and young age below 25 years (AOR: 4.30, 95% CI [1.39–3.35]; p = 0.011), urban residential area (AOR: 2.78, CI [1.23–7.09], p = 0.043), lack of employment (AOR: 1.75, 95% CI [1.05–2.91], p = 0.032), food insecurity (AOR: 2.67, 95% CI [7.59–8.97]; p < 0.0001), malnutrition (AOR: 1.55, 95% CI [1.94–2.56]; p = 0.027) and opportunistic infections (AOR: 1.81, 95% CI [1.11–2.97]; p = 0.018). Conclusion The prevalence of non-adherence to ART in this study was high. Sociodemographic and economic factors such as young age of below 25 years, urban residential area, lack of employment, food insecurity, malnutrition and opportunistic infections were among the factors associated with non-adherence to ART.

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Section: Discussionmentioning

confidence: 99%

Magnitude of non-adherence to antiretroviral therapy and associated factors among adult people living with HIV/AIDS in Benishangul-Gumuz Regional State, Ethiopia

Nigusso

Mavhandu-Mudzusi

2020

PeerJ

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“…Manuscript to be reviewed nutritious food support is highly regarded as a viable option to increase weight gain (Audain et al, 2015) and improve treatment outcome (Chaiyachati et al, 2014:Tiyou et al, 2012.…”

Section: Discussionmentioning

confidence: 99%

Peer Review #3 of "Magnitude of non-adherence to antiretroviral therapy and associated factors among adult people living with HIV/AIDS in Benishangul-Gumuz Regional State, Ethiopia (v0.2)"

2020

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Introduction. Following global efforts to increase antiretroviral therapy (ART) access and coverage, Ethiopia has made significant achievement with a 6.3% annual decline in the HIV/AIDS incidence rate between 1990 and 2016. Such success depends not only on access to ART but also on attaining optimum treatment adherence. Emerging studies in Ethiopia has shown the increasing prevalence of poor adherence and lack of the desired viral suppression, but the extent and factors associated with nonadherence to ART are not well known, especially in the current study setup. In this study, we examined the magnitude and factors associated with treatment and non-adherence to ART among people living with HIV in Benishangul-Gumuz Regional State, northwest Ethiopia. Methods. An institutional facility based cross-sectional descriptive study was carried out among adult people living with HIV/AIDS from mid-December 2016 to February 2017 with only 98.9% response rate. Sociodemographic factors (age, gender, marital status and residential area), economic factors (educational status, income, asset possession, employment status, dietary diversity, nutritional status and food security), and clinical characteristics (CD4 count, duration on ART and history of opportunistic infections) were explanatory variables. ART non-adherence was measured using a visual analogue scale (VAS). We used binary logistic regression and subsequent multivariate logistic regression analysis to determine the factors associated with ART non-adherence. Result. Overall, 39.7% of the participants were found non-adherent to ART. Strong association was found between non-adherence to ART and young age below 25 years (

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“… [33] The epidemic of peripheral neuropathy in Cuba and the facilitated crossing over of HIV in Africa could be explained by the emergence of virulent mutated RNA viruses in the population with micronutrient deficiency. [ 33 , 145 , 146 ]…”

Section: Search Strategy and Selection Criteriamentioning

confidence: 99%

Potential roles of micronutrient deficiency and immune system dysfunction in the coronavirus disease 2019 (COVID-19) pandemic

Gorji

Ghadiri

2021

Nutrition

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Highlights A robust immune response is crucial in the recovery COVID-19 infection. Micronutrients play a role in recruitment of immune responses (IR) to viral infections. Micronutrients deficiency (MD) contributes to the emergence of more virulent strains. MD and IR dysfunction may contribute to the morbidity of COVID-19 infection.

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Food supplementation among HIV-infected adults in Sub-Saharan Africa: impact on treatment adherence and weight gain

Cited by 25 publications

References 42 publications

Magnitude of non-adherence to antiretroviral therapy and associated factors among adult people living with HIV/AIDS in Benishangul-Gumuz Regional State, Ethiopia

Magnitude of non-adherence to antiretroviral therapy and associated factors among adult people living with HIV/AIDS in Benishangul-Gumuz Regional State, Ethiopia

Peer Review #3 of "Magnitude of non-adherence to antiretroviral therapy and associated factors among adult people living with HIV/AIDS in Benishangul-Gumuz Regional State, Ethiopia (v0.2)"

Potential roles of micronutrient deficiency and immune system dysfunction in the coronavirus disease 2019 (COVID-19) pandemic

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