Food sources and biomolecular targets of tyramine

Andersen, Gaby; Marcinek, Patrick; Sulzinger, Nicole; Schieberle, Peter; Krautwurst, Dietmar

doi:10.1093/nutrit/nuy036

Cited by 51 publications

(42 citation statements)

References 91 publications

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“…Tyramine is biogenic amine and is a decarboxyted product of tyrosine amino acid. It has both immunological and cardiovascular effects for differences in concentration at pico-nanomolar concentration (29). Tyramine concentration is affected by dietary as well GI bacteria (tyramine-producing bacteria e.g.…”

Section: Discussionmentioning

confidence: 99%

“…Tyramine concentration is affected by dietary as well GI bacteria (tyramine-producing bacteria e.g. Lactobacillus), and higher concentration of tyramine is associated with hypertension in humans (29). The hypertensive and atherogenic effects (of metabolites) could compromise the blood supply in various body tissues including in muscle tissue leading to atrophy and degradation, which could be pathophysiological condition occurring in myopathy bird.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Characterizing Woody Breast Myopathy in a Meat Broiler Line by Heat Production, Microbiota, and Plasma Metabolites

Maharjan¹,

Hilton²,

Weil³

et al. 2020

Front. Vet. Sci.

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Selection for quantitative traits in meat broilers such as breast yield and growth rate exert physiological pressure leading to ante mortem histological and biochemical alterations in muscle tissues. The poultry industry has recently witnessed a myopathy condition affecting Pectoralis major (breast muscle) of broilers, called woody breast (WB), an etiology still unclear to scientific community. A study was conducted to characterize the WB myopathy in a meat broiler line at its finishing phase (d 41) in terms of heat production (HP), microbiota and plasma metabolites. Two treatment groups were studied-WB affected (myopathy) and normal (non-myopathy) broiler; n = 20 in each group. Indirect calorimetry was utilized for HP measurement. Furthermore, body composition (BC) analysis was also performed using dual-energy x-ray absorptiometry (DEXA). Microbiota in ileal digesta was studied with PCR amplified 16s rRNA gene. LC-MS targeted metabolomics was performed to understand differential expression of plasma metabolites. Results showed that there was difference in fasting HP (P < 0.05) between these two treatment groups, with non-myopathy broiler producing more heat which was indicative of higher body protein content validated by higher protein: fat ratio by BC results. Less protein content in myopathy bird could be due to probable higher mixed muscle degradation occurring in lean tissue as marked by elevated 3-methylhistidine expression in plasma. Microbiota results showed unclassified Lactobacillus as predominant genus with higher abundance occurring in myopathy group; whereas at species level, L. acidipiscis was predominant bacteria for non-myopathy broiler. Differentially significant metabolites (P < 0.05) identified from plasma metabolome between these two treatment groups were homocysteine, cyclic GMP, trimethylamine N-oxide (TMAO), tyramine, carnitine, and acetylcarnitine, which were all associated to cardiovascular system. The findings suggest that more research in meat broilers could be opted toward delivering reduced vascularity issues to alleviate this myopathy condition.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Characterizing Woody Breast Myopathy in a Meat Broiler Line by Heat Production, Microbiota, and Plasma Metabolites

Maharjan¹,

Hilton²,

Weil³

et al. 2020

Front. Vet. Sci.

View full text Add to dashboard Cite

show abstract

“…In vitro studies with the model of BBB suggest that dietary tyramine can reach the central nervous system [47]. In humans, the diet seems to be the main source of physiologically relevant tyramine concentrations [46]. The mean concentration of 3HPAA was many times higher than that in corresponding plasma.…”

Section: -Hydroxyphenyl Acetic Acid In Csfmentioning

confidence: 99%

“…p-tyramine belongs to "trace amines" and can act as a neurotransmitter via G-protein coupled receptors in the brain. It can be formed endogenously as a product of enzymatic decarboxylation of tyrosine [45], or ingested with food (e.g., fish, cheese, chocolate, certain vegetables) [46]. In vitro studies with the model of BBB suggest that dietary tyramine can reach the central nervous system [47].…”

Section: -Hydroxyphenyl Acetic Acid In Csfmentioning

confidence: 99%

The Presence of Caffeic Acid in Cerebrospinal Fluid: Evidence That Dietary Polyphenols Can Cross the Blood-Brain Barrier in Humans

et al. 2020

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Epidemiological data indicate that a diet rich in plant polyphenols has a positive effect on brain functions, improving memory and cognition in humans. Direct activity of ingested phenolics on brain neurons may be one of plausible mechanisms explaining these data. This also suggests that some phenolics can cross the blood-brain barrier and be present in the brain or cerebrospinal fluid. We measured 12 phenolics (a combination of the solid-phase extraction technique with high-performance liquid chromatography) in cerebrospinal fluid and matched plasma samples from 28 patients undergoing diagnostic lumbar puncture due to neurological disorders. Homovanillic acid, 3-hydroxyphenyl acetic acid and caffeic acid were detectable in cerebrospinal fluid reaching concentrations (median; interquartile range) 0.18; 0.14 µmol/L, 4.35; 7.36 µmol/L and 0.02; 0.01 µmol/L, respectively. Plasma concentrations of caffeic acid (0.03; 0.01 µmol/L) did not correlate with those in cerebrospinal fluid (ρ = −0.109, p = 0.58). Because food (fruits and vegetables) is the only source of caffeic acid in human body fluids, our results indicate that the same dietary phenolics can cross blood-brain barrier in humans, and that transportation of caffeic acid through this barrier is not the result of simple or facilitated diffusion.

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“…MVA biosynthetic intermediates are crucial regulators of intrinsic immunity in bovine endometritis [39]. Tyramine is a biological trace amine that is generated through decarboxylation of the amino acid tyrosine, and substantial evidence suggest that tyramine is a neuroactive chemical exhibiting multiple physiological effects [41]; it can affect various physiological mechanisms, exhibits neuromodulatory properties and cardiovascular and immunological effects [42], stimulates the insulin-IGF-1 signaling (IIS) pathway, and blocks the induction of stress response genes by activating adrenergiclike receptors in the intestine. Tyrosine can directly or indirectly act on the ovaries to inhibit luteal function, thereby affecting reproduction.…”

Section: High-temperature Environment and Salivary Metabolitesmentioning

confidence: 99%

Characteristics of menstrual cycle disorder and saliva metabolomics of young women in high-temperature environment

Wei¹,

An²,

Fan³

et al. 2021

Preprint

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Objective: High-temperature environments induce menstrual disorders, which can seriously damage women's reproductive health and workability. The regulation mechanism underlying the induction of these disorders at high temperature is yet to be elucidated. Saliva is an information-rich biological fluid that can reflect systemic diseases. Blood metabolites can enter the saliva through extracellular, intracellular, or paracellular pathways. Therefore, saliva metabolites may provide a window for the early detection of diseases. Methods: Here, we investigated the characteristics of menstrual cycle disorders and saliva metabolomics. Women from high and normal temperature areas of China were selected and divided into two groups—high-temperature (H group) and control (C group). A questionnaire survey was conducted in summer (July) to investigate the incidence rate of menstrual disorders, characteristics of the disorders, and factors influencing the risk of these disorders in different regions. Metabolomics was applied to analyze the characteristics of the salivary metabolites and neurotransmitters in the two groups of women with menstrual disorders.Results: The incidence rate of menstrual disorders was significantly higher in the H group than in the C group (P < 0.05). High-temperature environment, anxiety, pressure, and sleep quality were identified as critical factors associated with menstrual disorders. Non-targeted saliva metabolomics identified 64 significantly different metabolites, which mainly enriched in metabolic pathways such as carbohydrate metabolism, membrane transport, digestive system, and nucleotide metabolism(P < 0.05). Targeted metabolomics of neurotransmitters revealed increased expression of histamine (HA) and glutamine and decreased expression of 5-hydroxyindole acetic acid (5-HIAA) (P < 0.05).Conclusions: The incidence rate of menstrual disorder was increased in the H group, which is significantly related to factors such as anxiety and pressure. Changes in metabolites and neurotransmitters indicated that besides mood, endocrine regulation mechanism, inflammatory reactions that affect the formation of the follicular, cell membrane might contribute to the development of menstrual disorders.

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Food sources and biomolecular targets of tyramine

Cited by 51 publications

References 91 publications

Characterizing Woody Breast Myopathy in a Meat Broiler Line by Heat Production, Microbiota, and Plasma Metabolites

Characterizing Woody Breast Myopathy in a Meat Broiler Line by Heat Production, Microbiota, and Plasma Metabolites

The Presence of Caffeic Acid in Cerebrospinal Fluid: Evidence That Dietary Polyphenols Can Cross the Blood-Brain Barrier in Humans

Characteristics of menstrual cycle disorder and saliva metabolomics of young women in high-temperature environment

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