Food Sensitivities and Psychological Disturbance: a Review

Gettis, Alan

doi:10.1177/026010608900600303

Cited by 4 publications

(1 citation statement)

References 35 publications

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“…A plethora of epidemiological and clinical data suggests higher incidence of anxiety and increased emotional reactivity in individuals suffering from allergies [15–21]. In studies of food allergy, specifically, it has been shown that the prevalence of anxiety or depression is higher in adults with food allergy than in nonhealthy controls with lactose intolerance or in healthy controls [22].…”

Section: Neural Activity In Allergymentioning

confidence: 99%

Neural Pathways in Allergic Inflammation

et al. 2010

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Allergy is on the rise worldwide. Asthma, food allergy, dermatitis, and systemic anaphylaxis are amongst the most common allergic diseases. The association between allergy and altered behavior patterns has long been recognized. The molecular and cellular pathways in the bidirectional interactions of nervous and immune systems are now starting to be elucidated. In this paper, we outline the consequences of allergic diseases, especially food allergy and asthma, on behavior and neural activity and on the neural modulation of allergic responses.

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Section: Neural Activity In Allergymentioning

confidence: 99%

Neural Pathways in Allergic Inflammation

et al. 2010

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Neural correlates of IgE-mediated food allergy

Basso¹,

Costa-Pinto²,

Russo³

et al. 2003

Journal of Neuroimmunology

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Neural and Behavioral Correlates of Food Allergy

Costa-Pinto

Basso

2012

Chemical Immunology and Allergy

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Food allergy accounts for a great number of reactions leading to diminished quality of life in western countries. There has been an abundance of reports of behavioral changes, as well as psychiatric conditions associated with food allergy over the past decades. Most of this field inspired little medical attention for its lack of a solid scientific ground. We review the literature on the association of food allergy and brain activity, leading to changes in emotion and behavior. Moreover, we describe an experimental paradigm employed to dissect the biological relevance of this association. Mice allergic to ovalbumin avoid a palatable sweet solution in order to escape contact with antigen. This choice is associated with increased levels of anxiety, compatible with a conflicting situation. These responses are associated with increased activity in brain areas associated with emotional and affective behavior, which are also important for anxiety and stress responses. Higher levels of corticosterone accompany these changes in behavior. These responses are mediated by specific antibodies and prevented by depletion or immunological tolerance. They are also partially mediated by C-sensitive afferents and mast cells. Far from anecdote, neural repercussions of food allergy should be considered when planning a therapeutic strategy in affected individuals.

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Food Sensitivities and Psychological Disturbance: a Review

Cited by 4 publications

References 35 publications

Neural Pathways in Allergic Inflammation

Neural Pathways in Allergic Inflammation

Neural correlates of IgE-mediated food allergy

Neural and Behavioral Correlates of Food Allergy

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