Food Restriction Inhibits the Growth of Intestinal Polyps in Multiple Intestinal Neoplasia Mouse

Kakuni, Masakazu; Morimura, Keiichiro; Wanibuchi, Hideki; Ogawa, Motome; Wei, Min; Hayashi, Shuji; Fukushima, Shoji

doi:10.1111/j.1349-7006.2002.tb02163.x

Cited by 14 publications

(18 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…An increase in physical activity without a change in food intake should have placed the treadmill runners in a state of negative caloric balance. Caloric restriction studies in Apc Min/ϩ mice have demonstrated a decrease on tumor formation and size, which is associated with a decrease in body weight (16,19). The decrease in body weight comes from decreased skeletal muscle and fat.…”

Section: Discussionmentioning

confidence: 99%

“…Both of these studies using Apc Min/ϩ mice point to gender as an important variable in modulating intestinal polyp development. However, a major caveat related to the second study was the extremely low number of intestinal polyps in control Apc Min/ϩ mice compared with other published studies (8,16,33).…”

mentioning

confidence: 82%

“…1). Acclimation consisted of running at gradually increasing speeds (10,12,16, and 18 m/min) at 5% grade for 20 min. After the acclimation period, the running protocol consisted of a brief 5-min warm-up (10 -14 m/min), followed by 55 min at 18 m/min and 5% grade.…”

Section: Methodsmentioning

confidence: 99%

See 2 more Smart Citations

Decreased intestinal polyp multiplicity is related to exercise mode and gender in Apc^Min/+ mice

Mehl¹,

Davis²,

Clements³

et al. 2005

Journal of Applied Physiology

113

View full text Add to dashboard Cite

Moderate-intensity treadmill running can alter male Apc(Min/+) mouse polyp formation. This purpose of this study was to examine whether exercise mode differentially affects Apc(Min/+) mouse intestinal polyp development in male and female mice. Male and female Apc(Min/+) mice were randomly assigned to control, treadmill (18 m/min; 60 min/day; 6 days/wk), or voluntary wheel running (24-h access) groups. Nine weeks of training decreased total intestinal polyps by 29% in male treadmill runners (66 +/- 9; P = 0.038) compared with male controls (93 +/- 7). The number of large polyps (>/=1-mm diameter) were also reduced by 38% in male treadmill runners (49 +/- 6; P = 0.005) compared with male controls (79 +/- 6). Treadmill running in female Apc(Min/+) mice and wheel running in both genders did not affect polyp number or size. Spleen weight decreased in male treadmill runners (91 +/- 9 mg; P = 0.011) and wheel runners (75 +/- 6 mg; P = 0.004) compared with controls (141 +/- 13 mg). Plasma IL-6 was reduced by 96% in male treadmill runners (1.2 +/- 0.6 pg/ml) and 78% in male wheel runners (6.6 +/- 3.3 pg/ml) compared with control mice (27.9 +/- 2.8 pg/ml; P < 0.05). Female mice responded similarly with an 86% decrease in plasma IL-6 with treadmill running (3.2 +/- 1.2 pg/ml) and 90% decrease with wheel running (2.9 +/- 2.0 pg/ml) compared with control mice (21.1 +/- 5.3 pg/ml; P < 0.05). The crypt depth-to-villus height ratio in the intestine, an indirect marker of intestinal inflammation, decreased by 21 (P = 0.024) and 24% (P = 0.029), respectively, in male and female treadmill runners but not wheel runners. Physical activity-induced attenuation of intestinal polyp number and size is dependent on exercise mode and differs between genders. The modulation of systemic and intestinal inflammation may also depend on exercise mode.

show abstract

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 82%

See 1 more Smart Citation

Decreased intestinal polyp multiplicity is related to exercise mode and gender in Apc^Min/+ mice

Mehl¹,

Davis²,

Clements³

et al. 2005

Journal of Applied Physiology

113

View full text Add to dashboard Cite

show abstract

“…Negative caloric balance induced by restricting caloric intake can prevent the development of tumors in Apc Min/+ mice (15, 20, 21). Likewise, excess consumption of calories can promote tumorigenesis.…”

Section: Introductionmentioning

confidence: 99%

The Interaction of a High-Fat Diet and Regular Moderate Intensity Exercise on Intestinal Polyp Development in ApcMin/+ Mice

Baltgalvis

Berger

Peña

et al. 2009

Cancer Prevention Research

View full text Add to dashboard Cite

AbstactDiet and exercise are two environmental factors that can alter colon cancer risk. The purpose of this study was to determine if regular moderate-intensity treadmill exercise training could attenuate polyp formation in Apc Min/+ mice fed the Western-style diet. Four-week-old male Apc Min/+ mice (n = 12 per group) were assigned to AIN-76A Control, AIN-76A Exercise, Western Control, or Western Exercise treatment groups. Mice were weaned to these diets and either subjected to regular moderate-intensity treadmill exercise (18 m/min, 60 min/d, 6 d/wk) or remained sedentary for 6 weeks. Mice fed the Western-style diet consumed ∼14% more calories and had 42% more epididymal fat compared with mice fed the AIN-76A diet. Exercise had no effect on fat pad mass with either diet treatment. Exercise reduced total intestinal polyp number by 50% and the number of large polyps (>1 mm diameter) by 67% in AIN-76A-fed mice. The Western-style diet increased polyp number by 75% when compared with AIN-76A-fed mice, but exercise did not decrease polyp number or alter polyp size in mice fed the Western-style diet. Markers of systemic inflammation and immune system function were improved with exercise in mice fed the AIN-76A diet. Mice fed the Western-style diet showed more inflammation and immunosuppression, which were not completely ameliorated by exercise. These data suggest that the induction of adiposity, inflammation, and immunosuppression by the Western-style diet may compromise the beneficial effect of moderate-intensity exercise on the intestinal polyp burden in Apc Min/+ mice.Colon cancer is the third most common type of cancer among American men and women (1). The lifetime probability of developing colorectal cancer is 1 in 18 for men and 1 in 19 for women (1). The main risk factors for developing colorectal cancer include age, family history, and environmental causes. Two environmental risk factors for colon cancer include a high-fat diet and physical inactivity, which can lead to obesity (1-4). A recent meta-analysis has summarized the epidemiologic studies on colon cancer risk and obesity. When examining 26 studies including more than 70,000 colorectal cancer cases that reported body mass index, individuals with a body mass index >30 kg/m 2 had a 20% greater risk for developing colorectal cancer compared with those with a normal body mass index (<25 kg/m 2 ; ref. 5). Because the lack of regular physical activity and poor dietary habits contribute to body weight gain, it remains important to determine how these factors contribute to the initiation and progression of colon cancer.The preventative effects of physical activity and/or exercise on colorectal cancer risk have been reviewed, and the data are convincing that physical activity is protective (3,(6)(7)(8). A meta-analysis examining the rates of colon cancer showed that both active men and women have an overall relative risk of 0.79 and 0.78, respectively, of developing colon cancer (6). The hypothesized mechanisms include improved immune function, decreased gastr...

show abstract

“…Studies assessing tumor initiation in the calorie restricted intestine in the same strain of mice and using the same or different (Tsao et al, 2002) genetic cancer models come to divergent conclusions. In general, all of these studies report a reduction in the overall size of adenomas consistent with the anti-growth effects of calorie restriction, but in terms of incidence some report either a neutral or negative effect (Kakuni et al, 2002; Mai et al, 2003). In another study by Weindruch and colleagues, calorie restriction, when started in middle aged mice, actually increased the incidence of spontaneous cancers (Pugh et al, 1999).…”

Section: Diet Stem Cells and Cancer Incidencementioning

confidence: 92%

Dietary and Metabolic Control of Stem Cell Function in Physiology and Cancer

2014

View full text Add to dashboard Cite

Organismal diet has a profound impact on tissue homeostasis and health in mammals. Adult stem cells are a keystone of tissue homeostasis that alter tissue composition by balancing self-renewal and differentiation divisions. Because somatic stem cells may respond to shifts in organismal physiology to orchestrate tissue remodeling and some cancers are understood to arise from transformed stem cells, there is a likely possibility that organismal diet, stem cell function, and cancer initiation are interconnected. Here we will explore the emerging effects of diet on nutrient-sensing pathways active in mammalian tissue stem cells and their relevance to normal and cancerous growth.

show abstract

Food Restriction Inhibits the Growth of Intestinal Polyps in Multiple Intestinal Neoplasia Mouse

Cited by 14 publications

References 35 publications

Decreased intestinal polyp multiplicity is related to exercise mode and gender in Apc^Min/+ mice

Decreased intestinal polyp multiplicity is related to exercise mode and gender in Apc^Min/+ mice

The Interaction of a High-Fat Diet and Regular Moderate Intensity Exercise on Intestinal Polyp Development in ApcMin/+ Mice

Dietary and Metabolic Control of Stem Cell Function in Physiology and Cancer

Contact Info

Product

Resources

About

Food Restriction Inhibits the Growth of Intestinal Polyps in Multiple Intestinal Neoplasia Mouse

Cited by 14 publications

References 35 publications

Decreased intestinal polyp multiplicity is related to exercise mode and gender in ApcMin/+ mice

Decreased intestinal polyp multiplicity is related to exercise mode and gender in ApcMin/+ mice

The Interaction of a High-Fat Diet and Regular Moderate Intensity Exercise on Intestinal Polyp Development in ApcMin/+ Mice

Dietary and Metabolic Control of Stem Cell Function in Physiology and Cancer

Contact Info

Product

Resources

About

Decreased intestinal polyp multiplicity is related to exercise mode and gender in Apc^Min/+ mice

Decreased intestinal polyp multiplicity is related to exercise mode and gender in Apc^Min/+ mice