Food restriction as a modulator of age-related changes in serum lipids

Liepa, George U.; Ej, Masoro; Bertrand, Helen A.; Yu, Bo

doi:10.1152/ajpendo.1980.238.3.e253

Cited by 36 publications

(23 citation statements)

References 13 publications

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“…Old age is associated with changes in the hepatic synthesis and expression of many proteins (Swindell 2008;Tollet-Egnell et al 2001;Ward and Richardson 1991) and a substantial increase in blood cholesterol and triglyceride concentrations in many species including the Fischer F344 rat used in this study (Liepa et al 1980;Lingelbach and McDonald 2000;Masoro et al 1983). However, in this study, we found no significant change in the liver levels of apoE mRNA or protein.…”

Section: Discussioncontrasting

confidence: 66%

The effect of old age on apolipoprotein E and its receptors in rat liver

Sabaretnam

O'Reilly

Kritharides

et al. 2009

AGE

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Apolipoprotein E (apoE) is associated with aging and some age-related diseases. The majority of apoE is produced by hepatocytes for the receptormediated uptake of lipoproteins. Here, the effects of age on the hepatic expression and distribution of apoE and its receptors were determined using immunofluorescence, Western blots, and quantitative PCR in rat liver tissue and isolated hepatocytes. The expression of apoE mRNA and protein was not influenced significantly by aging. Immunofluorescence studies in isolated hepatocytes showed that apoE was more likely to be co-localized with early endosomes, golgi, and microtubules in isolated old hepatocytes. The mRNA expression of the receptor involved in sequestration of apoE, heparan sulfate proteoglycan was reduced in old age, without any significant effect on the expression of either the low-density lipoprotein receptor or low density-lipoprotein receptor-related protein. Old age is associated with changes in hepatic apoE intracellular trafficking and heparan sulfate proteoglycan expression that might contribute to age-related disease.

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Section: Discussioncontrasting

confidence: 66%

The effect of old age on apolipoprotein E and its receptors in rat liver

Sabaretnam

O'Reilly

Kritharides

et al. 2009

AGE

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“…Analysis of serum triglycerides (TGs) revealed that CR reduced many individual TG species (Dataset S1) and total TG levels ( Fig. S1L), consistent with elevated lipid oxidation and reduced fat stores during CR, as other groups have shown (29,30). Altogether, even though CR triggered large shifts in serum metabolomic profiles, both FLOX and MKO mice showed broadly similar responses to CR.…”

Section: Improvements In Metabolic Homeostasis During Cr Do Not Requirementioning

confidence: 55%

Skeletal muscle transcriptional coactivator PGC-1α mediates mitochondrial, but not metabolic, changes during calorie restriction

Finley

Lee

Souza

et al. 2012

Proc. Natl. Acad. Sci. U.S.A.

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Calorie restriction (CR) is a dietary intervention that extends lifespan and healthspan in a variety of organisms. CR improves mitochondrial energy production, fuel oxidation, and reactive oxygen species (ROS) scavenging in skeletal muscle and other tissues, and these processes are thought to be critical to the benefits of CR. PGC-1α is a transcriptional coactivator that regulates mitochondrial function and is induced by CR. Consequently, many of the mitochondrial and metabolic benefits of CR are attributed to increased PGC-1α activity. To test this model, we examined the metabolic and mitochondrial response to CR in mice lacking skeletal muscle . Surprisingly, MKO mice demonstrated a normal improvement in glucose homeostasis in response to CR, indicating that skeletal muscle PGC-1α is dispensable for the wholebody benefits of CR. In contrast, gene expression profiling and electron microscopy (EM) demonstrated that PGC-1α is required for the full CR-induced increases in mitochondrial gene expression and mitochondrial density in skeletal muscle. These results demonstrate that PGC-1α is a major regulator of the mitochondrial response to CR in skeletal muscle, but surprisingly show that neither PGC-1α nor mitochondrial biogenesis in skeletal muscle are required for the whole-body metabolic benefits of CR.

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“…Lower serum HDL2b is inversely related to atherosclerosis in humans (48-53) Thus, the significant increase in HDL2b seen in CR monkeys suggests a reduced occurrence of cardiovascular disease. Findings related to serum lipids in CR rodents also suggest improvements in cardiovascular disease risk (54)(55)(56)(57). The effects of CR on triglycerides and HDL2b, are unique in that only total calorie intake was reduced, while cholesterol, fatty acid composition, and the proportion of fat, protein, and carbohydrates were not changed.…”

Section: Fasting Fasting Insulin Sensitiwty ~ Glucosementioning

confidence: 98%

Beyond the rodent model: Calorie restriction in rhesus monkeys

Lane

Ingram

Roth

1997

AGE

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Lifespan extension and reduction of age-related disease by calorie restriction (CR) are among the most consistent findings in gerontological research. The well known effects of CR have been demonstrated many times in rodents and other short-lived species. However, effects of CR on aging in longerlived species, more closely related to humans, were unknown until recently. Studies of CR and aging using nonhuman primates (rhesus monkeys) were begun several years ago at the National Institute on Aging, the University of Wisconsin-Madison, and the University of Maryland. These studies are beginning to yield useful data regarding the effects of this nutritional intervention in primates. Several studies from these ongoing investigations have shown that rhesus monkeys on CR exhibit physiological responses to CR that parallel findings in rodents. In addition, several potential biomarkers of aging are being evaluated and preliminary findings suggest the possibility that CR in rhesus monkeys could slow the rate of aging and reduce age-related disease, specifically diabetes and cardiovascular disease. It will be several years before conclusive proof that CR slows aging and extends life span in primates is established, however, results from these exciting studies suggest the possibility that the anti-aging effects of CR reported in rodents also occur in longer-lived species such as nonhuman primates, strenghtening the possibility that this nutritional intervention will also prove beneficial in longer-lived species, including humans.

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Food restriction as a modulator of age-related changes in serum lipids

Cited by 36 publications

References 13 publications

The effect of old age on apolipoprotein E and its receptors in rat liver

The effect of old age on apolipoprotein E and its receptors in rat liver

Skeletal muscle transcriptional coactivator PGC-1α mediates mitochondrial, but not metabolic, changes during calorie restriction

Beyond the rodent model: Calorie restriction in rhesus monkeys

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