Food protein–induced enterocolitis syndrome in the US population–based study

Nowak‐Węgrzyn, Anna; Warren, Christopher; Brown‐Whitehorn, Terri; Cianferoni, Antonella; Schultz‐Matney, Fallon; Gupta, Ruchi S.

doi:10.1016/j.jaci.2019.06.032

Cited by 72 publications

(40 citation statements)

References 9 publications

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“…This includes patients with respiratory sensitization to a large number of allergen families and patients with pollen-food or inhalant food syndromes. Another relevant application of PAMD@ is food allergy and the food proteininduced enterocolitis syndrome, [84][85][86] because it is now possible to determine the individual pattern of IgE sensitization by analyzing single allergenic molecules instead of complex allergenic extracts.…”

Section: Patients Most Likely To Benefit From Pamd@mentioning

confidence: 99%

A WAO — ARIA — GA2LEN consensus document on molecular-based allergy diagnosis (PAMD@): Update 2020

Ansotegui¹,

Melioli²,

Canonica³

et al. 2020

World Allergy Organization Journal

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Precision allergy molecular diagnostic applications (PAMD@) is increasingly entering routine care. Currently, more than 130 allergenic molecules from more than 50 allergy sources are commercially available for in vitro specific immunoglobulin E (sIgE) testing. Since the last publication of this consensus document, a great deal of new information has become available regarding this topic, with over 100 publications in the last year alone. It thus seems quite reasonable to publish an update. It is imperative that clinicians and immunologists specifically trained in allergology keep abreast of the new and rapidly evolving evidence available for PAMD@. PAMD@ may initially appear complex to interpret; however, with increasing experience, the information gained provides relevant information for the allergist. This is especially true for food allergy, Hymenoptera allergy, and for the selection of allergen immunotherapy. Nevertheless, all sIgE tests, including PAMD@, should be evaluated within the framework of a patient's clinical history, because allergen sensitization does not necessarily imply clinical relevant allergies.

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Section: Patients Most Likely To Benefit From Pamd@mentioning

confidence: 99%

A WAO — ARIA — GA2LEN consensus document on molecular-based allergy diagnosis (PAMD@): Update 2020

Ansotegui¹,

Melioli²,

Canonica³

et al. 2020

World Allergy Organization Journal

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“…As noted above, sesame has been associated recently with AFPIES and EOE [66][67][68][69]. However, the biochemical nature of allergens responsible for triggering these immune reactions is unknown.…”

Section: The Biochemical Diversity Of Sesame Allergens: Proteins and mentioning

confidence: 99%

“…The fourth type involves acute reactions with colic and diarrhea within 1-4 h upon eating sesame. This condition is known as acute food protein-induced enterocolitis syndrome (AFPIES) with explosive (or projectile) vomiting as the most common symptom [66,67]. This reaction can be potentially fatal in infants and children.…”

Section: Sesame Allergy: a Complex Spectrum Of Clinical Presentationsmentioning

confidence: 99%

“…Sesame is also increasingly linked to two other less understood types of allergic reactions: acute food-protein induced enterocolitis syndrome (AFPIES) and eosinophilic esophagitis (EOE) [66][67][68][69]. Both of these are non-IgE allergic reactions mediated by unknown mechanisms.…”

Section: Does Sesame Use Additional Immune Mechanisms To Trigger Allementioning

confidence: 99%

“…The AFPIES is characterized by vomiting, lethargy, and diarrhea in infants and children within 1-4 h after feeding. This requires immediate medical help because it can be life-threatening due to dehydration and shock [66]. Many major allergenic foods (milk, egg etc.…”

Section: Does Sesame Use Additional Immune Mechanisms To Trigger Allementioning

confidence: 99%

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The Global Rise and the Complexity of Sesame Allergy: Prime Time to Regulate Sesame in the United States of America?

Gangur

Acharya

2020

Allergies

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Sesame allergy is a life-threatening disease that has been growing globally with poorly understood mechanisms. To protect sensitive consumers, sesame is regulated in many countries. There were four research goals for this work on sesame allergy: (i) to map the timeline, and the extent of its global rise; (ii) to dissect the complexity of the disease, and its mechanisms; (iii) to analyze the global regulation of sesame; and (iv) to map the directions for future research and regulation. We performed a literature search on PubMed and Google Scholar, using combinations of key words and analyzed the output. Regulatory information was obtained from the government agencies. Information relevant to the above goals was used to make interpretations. We found that: (i) the reports appeared first in 1950s, and then rapidly rose globally from 1990s; (ii) sesame contains protein and lipid allergens, a unique feature not found in other allergenic foods; (iii) it is linked to five types of diseases with understudied mechanisms; and (iv) it is a regulated allergen in 32 advanced countries excluding the USA. We also provide directions for filling gaps in the research and identify implications of possible regulation of sesame in the USA.

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