Food Protein-Based Nanodelivery Systems for Hydrophobic and Poorly Soluble Compounds

Maviah, Mily Bazezy Joelle; Farooq, Muhammad Asim; Mavlyanova, Rukhshona; Veroniaina, Hanitrarimalala; Filli, Mensura Sied; Aquib, Md; Kesse, Samuel; Boakye‐Yiadom, Kofi Oti; Wang, Bo

doi:10.1208/s12249-020-01641-z

Cited by 10 publications

(8 citation statements)

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“…Another study reported that protein segments generated by the digestion of sodium caseinate (SC) formed a stable emulsion, carrying lipophilic compounds such as β-carotene, preventing its oxidation and facilitating its transfer into mixed micelles, which increased the bioaccessibility of β-carotene [29]. However, while proteins have received much interest from pharmaceutical and food industries, especially for encapsulation and delivery of lipophilic compounds [30,31], including carotenoids [32], very little is known about the influence that proteins could have on the bioavailability of carotenoids, under conditions resembling the in vivo environment.…”

Section: Introductionmentioning

confidence: 99%

Impact of Protein-Enriched Plant Food Items on the Bioaccessibility and Cellular Uptake of Carotenoids

et al. 2021

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Carotenoids are lipophilic pigments which have been associated with a number of health benefits, partly related to antioxidant effects. However, due to their poor solubility during digestion, carotenoid bioavailability is low and variable. In this study, we investigated the effect of frequently consumed proteins on carotenoid bioaccessibility and cellular uptake. Whey protein isolate (WPI), soy protein isolate (SPI), sodium caseinate (SC), gelatin (GEL), turkey and cod, equivalent to 0/10/25/50% of the recommended dietary allowance (RDA, approx. 60g/d), were co-digested gastro-intestinally with carotenoid-rich food matrices (tomato and carrot juice, spinach), and digesta further studied in Caco-2 cell models. Lipid digestion, surface tension and microscopic visualization were also carried out. Co-digested proteins positively influenced the micellization of carotenes (up to 3-fold, depending on type and concentration), especially in the presence of SPI (p < 0.001). An increased cellular uptake was observed for xanthophylls/carotenes (up to 12/33%, p < 0.001), which was stronger for matrices with an initially poor carotenoid micellization (i.e., tomato juice, p < 0.001), similar to what was encountered for bioaccessibility. Turkey and cod had a weaker impact. Significant interactions between carotenoids, lipids and proteins were observed during digestion. Co-digested proteins generally improved lipid digestion in all matrices (p < 0.001), especially for carrot juice, though slight decreases were observed for GEL. Protein impact on the surface tension was limited. In conclusion, proteins generally improved both carotenoid bioaccessibility and cellular uptake, depending on the matrices and carotenoid-type (i.e., carotene vs. xanthophylls), which may be relevant under specific circumstances, such as intake of carotenoid-rich food items low in lipids.

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Section: Introductionmentioning

confidence: 99%

Impact of Protein-Enriched Plant Food Items on the Bioaccessibility and Cellular Uptake of Carotenoids

et al. 2021

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“…This includes casein, whey, gelatin, albumin, silk, zein, gliadin, soy, and pea ( Dai et al, 2019 ; Stevenson, Lewis & Whittington, 2018 ; Takeuchi et al, 2019 ; Tari et al, 2018 ). Recent increase in interest in plant-based protein NDS relates to their lower susceptibility to pathogenic infections compared to animal-sourced materials ( Maviah et al, 2020 ), suitability for those who follow certain religious practices or vegan diet, and general environmental sustainability.…”

Section: Protein Based Nano-delivery Systemsmentioning

confidence: 99%

“…Several studies have examined the use of whey proteins from animal sources in NDS for food due to their positive impact on texture and quality ( Ha et al, 2019 ; Liu et al, 2021 ; Sampathkumar, Tan & Say, 2020 ). Whey proteins have been used to incorporate vitamins such as folate ( Sampathkumar, Tan & Say, 2020 ) and folic acid, β-carotene, and caffeine ( Liu et al, 2021 ) in NDS as nanosuspensions, solid dispersions, nano-emulsions, and hydrogels ( Farooq et al, 2019 ; Maviah et al, 2020 ).…”

Section: Protein Based Nano-delivery Systemsmentioning

confidence: 99%

“…Literature searches reveal limited studies on the use of plant-based protein NDS in food products. Zein protein found in corn, which is primarily comprised of non-polar amino acids, has hydrophobic properties and is soluble in aqueous-alcohol solutions ( Maviah et al, 2020 ). These properties as well as its gelling and adhesive properties make zein proteins an ideal nanocarrier for hydrophobic and hydrophobic biomolecules ( Maviah et al, 2020 ).…”

Section: Applications Of Nano-delivery Systems In Food Product Develo...mentioning

confidence: 99%

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Current trends in nano-delivery systems for functional foods: a systematic review

Otchere

McKay

English

et al. 2023

PeerJ

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Background Increased awareness of the relationship between certain components in food beyond basic nutrition and health has generated interest in the production and consumption. Functional foods owe much of their health benefits to the presence of bioactive components. Despite their importance, their poor stability, solubility, and bioavailability may require the use of different strategies including nano-delivery systems (NDS) to sustain delivery and protection during handling, storage, and ingestion. Moreover, increasing consumer trend for non-animal sourced ingredients and interest in sustainable production invigorate the need to evaluate the utility of plant-based NDS. Method In the present study, 129 articles were selected after screening from Google Scholar searches using key terms from current literature. Scope This review provides an overview of current trends in the use of bioactive compounds as health-promoting ingredients in functional foods and the main methods used to stabilize these components. The use of plant proteins as carriers in NDS for bioactive compounds and the merits and challenges of this approach are also explored. Finally, the review discusses the application of protein-based NDS in food product development and highlights challenges and opportunities for future research. Key Findings Plant-based NDS is gaining recognition in food research and industry for their role in improving the shelf life and bioavailability of bioactives. However, concerns about safety and possible toxicity limit their widespread application. Future research efforts that focus on mitigating or enhancing their safety for food applications is warranted.

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“…Over the past decade or so, there has been a great deal of interest in developing colloidal delivery systems that can encapsulate, protect, and release bioactive substances, such as drugs, nutrients, and nutraceuticals [ 1 , 2 , 3 ]. To be suitable for commercial applications, these delivery systems should be fabricated from affordable and label-friendly food ingredients using cost-effective and sustainable manufacturing operations that are capable of being scaled up [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

Co-Encapsulation of Tannic Acid and Resveratrol in Zein/Pectin Nanoparticles: Stability, Antioxidant Activity, and Bioaccessibility

Liang

Cheng

Liang

et al. 2022

Foods

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Hydrophilic tannic acid and hydrophobic resveratrol were successfully co-encapsulated in zein nanoparticles prepared using antisolvent precipitation and then coated with pectin by electrostatic deposition. The encapsulation efficiencies of the tannic acid and resveratrol were 51.5 ± 1.9% and 77.2 ± 3.2%, respectively. The co-encapsulated nanoparticles were stable against aggregation at the investigated pH range of 2.0 to 8.0 when heated at 80 °C for 2 h and when the NaCl concentration was below 50 mM. The co-encapsulated tannic acid and resveratrol exhibited stronger in vitro antioxidant activity than ascorbic acid, as determined by 1,1-diphenyl-2-picrylhydrazyl free radical (DPPH·) and 2,2′-azinobis (3-ethylberizothiazoline-6-sulfonic acid) radical cation (ABTS+·) scavenging assays. The polyphenols-loaded nanoparticles significantly decreased the malondialdehyde (MDA) concentration and increased the superoxide dismutase (SOD) and catalase (CAT) activities in peroxide-treated human hepatoma cells (HepG2). An in vitro digestion model was used to study the gastrointestinal fate of the nanoparticles. In the stomach, encapsulation inhibited tannic acid release, but promoted resveratrol release. However, in the small intestine, it led to a relatively high bioaccessibility of 76% and 100% for resveratrol and tannic acid, respectively. These results suggest that pectin-coated zein nanoparticles have the potential for the co-encapsulation of both polar and nonpolar nutraceuticals or drugs.

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Food Protein-Based Nanodelivery Systems for Hydrophobic and Poorly Soluble Compounds

Cited by 10 publications

References 77 publications

Impact of Protein-Enriched Plant Food Items on the Bioaccessibility and Cellular Uptake of Carotenoids

Impact of Protein-Enriched Plant Food Items on the Bioaccessibility and Cellular Uptake of Carotenoids

Current trends in nano-delivery systems for functional foods: a systematic review

Co-Encapsulation of Tannic Acid and Resveratrol in Zein/Pectin Nanoparticles: Stability, Antioxidant Activity, and Bioaccessibility

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