Food is medicine: actions to integrate food and nutrition into healthcare

Downer, Sarah; Berkowitz, Seth A.; Harlan, Timothy S.; Olstad, Dana Lee; Mozaffarian, Dariush

doi:10.1136/bmj.m2482

Cited by 217 publications

(234 citation statements)

References 34 publications

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“…35 In the face of the time-consuming research and development processes of novel radioprotective agents, there is an emerging focus on the use of auxiliary means, such as dietary interventions, to prevent, manage, and treat complications. 36,37 In this study, we report that 10 days of 30% CR preconditioning alleviates radiation-induced hematopoietic and gastrointestinal syndromes in both male and female experimental animals. In brief, short-term CR structures sex-specific gut microbiota configurations to mitigate different types of intestinal radiation toxicity.…”

Section: Discussionmentioning

confidence: 64%

Caloric restriction alleviates radiation injuries in a sex‐dependent fashion

Dong

Xiao

et al. 2021

FASEB j.

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Safe and effective regimens are still needed given the risk of radiation toxicity from iatrogenic irradiation. The gut microbiota plays an important role in radiation damage. Diet has emerged as a key determinant of the intestinal microbiome signature and function. In this report, we investigated whether a 30% caloric restriction (CR) diet may ameliorate radiation enteritis and hematopoietic toxicity. Experimental mice were either fed ad libitum (AL) or subjected to CR preconditioning for 10 days and then exposed to total body irradiation (TBI) or total abdominal irradiation (TAI). Gross examinations showed that short-term CR pretreatment restored hematogenic organs and improved the intestinal architecture in both male and female mice. Intriguingly, CR preconditioning mitigated radiation-induced systemic and enteric inflammation in female mice, while gut barrier function improved in irradiated males. 16S rRNA high-throughput sequencing showed that the frequency of pro-inflammatory microbes, including Helicobacter and Desulfovibrionaceae, was reduced in female mice after 10 days of CR preconditioning, while an enrichment of short-chain fatty acid (SCFA)-producing bacteria, such as Faecalibaculum, Clostridiales, and Lactobacillus, was observed in males. Using fecal microbiota transplantation (FMT) or antibiotic administration to alter the gut microbiota counteracted the short-term CR-elicited radiation tolerance of both male and female mice, further indicating that the radioprotection of a 30% CR diet depends on altering the gut microbiota. Together, our findings provide new insights into CR in clinical applications and indicate that a short-term CR diet prior to radiation modulates sexspecific gut microbiota configurations, protecting male and female mice against the side effects caused by radiation challenge.

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Section: Discussionmentioning

confidence: 64%

Caloric restriction alleviates radiation injuries in a sex‐dependent fashion

Dong

Xiao

et al. 2021

FASEB j.

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“…The emergence of the food pharmacy concept – an umbrella term for programs designed to increase public access to fruits and vegetables – has the potential to elicit changes in eating patterns, if sustainable and effective methods are developed. Food pharmacy, also coined “food farmacy,” is a component of the “food is medicine” initiative, which aims to integrate or coordinate nutrition interventions with the healthcare system [ 3 ], though a number of food pharmacy programs have also been undertaken outside of the healthcare system [ 4 , 5 ]. Food pharmacy programs primarily focus on removing barriers to healthy eating, such as financial constraints, through coupons and financial incentives to promote consumption of healthy foods, particularly fruits and vegetables.…”

Section: Introductionmentioning

confidence: 99%

The food pharmacy: Theory, implementation, and opportunities

Donohue¹,

Severson

Martin

2021

American Journal of Preventive Cardiology

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The food pharmacy is an emerging program model designed to increase the access to and consumption of healthful foods, particularly fruits and vegetables. Existing research on the efficacy of the food pharmacy model shows that these programs have been effective in improving patient understanding of nutrition and removing barriers to healthy eating, and in turn may have a significant impact on diet-related health outcomes. However, efforts to date aiming to evaluate program effectiveness have been small and lack rigorous research methods. More research is needed to adequately assess the longitudinal effects of food pharmacy programs on healthful food intake and diet-related health outcomes. In this review, we outline the strengths and limitations of previous programs and explore possible options to improve the scalability and sustainability of food pharmacy programs.

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“…For example, in 2010 Pakistan had a Gender Efficiency Measurement (GEM) status of 92 out of 94 countries, while Gender Development (GDI) ranking 120 out of 146 (UNDP, 2010). Many socio-economic problems in Pakistan are aggravated as Pakistani women are faced with birth barriers and cannot achieve equality of access to resources, such as food, education, and healthcare (Downer et al, 2020). In 2004, the Pakistani government adopted many policies for improving education and gender equality for women.…”

Section: Introductionmentioning

confidence: 99%

A Nexus Between Household Characteristics and Women’s Empowerment: A Case Study of Punjab, Pakistan

Batool

Anwar

Asghar

et al. 2021

HSSR

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Purpose of the study: The empowerment of women is an important aim for them to be fully engaged in economic life and to achieve sustainable growth worldwide. One form of empowerment is to provide women with basic facilities. Methodology: The study also analyzed the impact on women's empowerment by primary data taken via multi-phase cluster sampling methods of household socio-economic and cultural characteristics in Punjab. Given the diversity of nature and context, the 6-dimensional empirical polychoric principles of empowering women generate a stringent cumulative index of women's autonomy. Main Findings: The empirical findings show that empowering women and their six-dimensional effects are positive for women's years and jobs, legal advertisements, health care institutions, social participation, safe, smooth surroundings, communication, politics and residential negative participation, unpaid housekeeping, and the fear of violence. The results show that women's empowerment is positive. Applications of this study: This study can be more effective in the manner that to offer women free advice about their rights through electronic media, the government should establish an integrated legal cell with the local government. Novelty/Originality of this study: This research contribution in the field of women empowerment that how women can deal with legal advisory, to get jobs, protection in health and institutions.

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Food is medicine: actions to integrate food and nutrition into healthcare

Abstract: Sarah Downer and colleagues review new efforts to incorporate food and nutrition into prevention, management, and treatment of diet related disease in healthcare systems

Cited by 217 publications

References 34 publications

Caloric restriction alleviates radiation injuries in a sex‐dependent fashion

Caloric restriction alleviates radiation injuries in a sex‐dependent fashion

The food pharmacy: Theory, implementation, and opportunities

A Nexus Between Household Characteristics and Women’s Empowerment: A Case Study of Punjab, Pakistan

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