Food Intake during the Normal Activity Phase Prevents Obesity and Circadian Desynchrony in a Rat Model of Night Work

Salgado‐Delgado, Roberto; Ángeles-Castellanos, Manuel; Saderi, Nadia; Buijs, Ruud M.; Escobar, Carolina

doi:10.1210/jcem.95.2.9987

Cited by 35 publications

(76 citation statements)

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“…Thereby, we assume that our SHIFTWORK rats did not shift most of their feeding to their shiftwork period as described by Salgado-Delgado et al (2008). When these authors prevented the shift in feeding by restricting shiftworkers' food availability to the dark phase (when they are back in their home cages), they also no longer observed an increased growth rate in shiftworking rats (Salgado-Delgado et al, 2010). Alternatively, our shiftwork rats could also, for example, have eaten less than the other groups.…”

Section: Discussionmentioning

confidence: 88%

“…A repetitive shift of the LD cycle has been proposed as an animal model for shiftwork (Bartol-Munier et al, 2006;Tsai et al, 2005). However, this procedure shows more resemblance to repetitive jetlag caused by traveling to different time zones than to shiftwork where the LD cycle stays continuous and activity is altered respective to the LD phase (Salgado-Delgado et al, 2010). Another proposed model limits the availability of food and access to an activity wheel to the light (inactive) phase (Murphy et al, 2003).…”

Section: Introductionmentioning

confidence: 99%

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Unaltered Instrumental Learning and Attenuated Body-Weight Gain in Rats During Non-rotating Simulated Shiftwork

Leenaars

Kalsbeek²,

Hanegraaf

et al. 2012

Chronobiology International

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Exposure to shiftwork has been associated with multiple health disorders and cognitive impairments in humans. We tested if we could replicate metabolic and cognitive consequences of shiftwork, as reported in humans, in a rat model comparable to 5 wks of non-rotating night shifts. The following hypotheses were addressed: (i) shiftwork enhances body-weight gain, which would indicate metabolic effects; and (ii) shiftwork negatively affects learning of a simple goal-directed behavior, i.e., the association of lever pressing with food reward (instrumental learning), which would indicate cognitive effects. We used a novel method of forced locomotion to model work during the animals' normal resting period. We first show that Wistar rats, indeed, are active throughout a shiftwork protocol. In contrast with previous findings, the shiftwork protocol attenuated the normal weight gain to 76 ± 8 g in 5 wks as compared to 123 ± 15 g in the control group. The discrepancy with previous work may be explained by the concurrent observation that with our shiftwork protocol rats did not adjust their between-work circadian activity pattern. They maintained a normal level of activity during the "off-work" periods. In the control experiment, rats were kept active during the dark period, normally dominated by activity. This demonstrated that forced activity, per se, did not affect body-weight gain (mean ± SEM: 85 ± 11 g over 5 wks as compared to 84 ± 11 g in the control group). Rats were trained on an instrumental learning paradigm during the fifth week of the protocol. All groups showed equivalent increases in lever pressing from the first (3.8 ± .7) to the sixth (21.3 ± 2.4) session, and needed a similar amount of sessions (5.1 ± .3) to reach a learning criterion (≥ 27 out of 30 lever presses). These results suggest that while on prolonged non-rotating shiftwork, not fully reversing the circadian rhythm might actually be beneficial to prevent body-weight gain and cognitive impairments.

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Section: Discussionmentioning

confidence: 88%

Section: Introductionmentioning

confidence: 99%

Unaltered Instrumental Learning and Attenuated Body-Weight Gain in Rats During Non-rotating Simulated Shiftwork

Leenaars

Kalsbeek²,

Hanegraaf

et al. 2012

Chronobiology International

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“…Studies implementing 12‐hour TRF windows in animals demonstrate conflicting findings for body weight . In two short‐term studies (4 weeks), mice fed during a 12‐hour TRF window in either the light phase or dark phase demonstrated no change in body weight versus controls.…”

Section: Animal Studiesmentioning

confidence: 98%

Time-restricted feeding and risk of metabolic disease: a review of human and animal studies

et al. 2014

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Time-restricted feeding (TRF), a key component of intermittent fasting regimens, has gained considerable attention in recent years. TRF allows ad libitum energy intake within controlled time frames, generally a 3-12 hour range each day. The impact of various TRF regimens on indicators of metabolic disease risk has yet to be investigated. Accordingly, the objective of this review was to summarize the current literature on the effects of TRF on body weight and markers of metabolic disease risk (i.e., lipid, glucoregulatory, and inflammatory factors) in animals and humans. Results from animal studies show TRF to be associated with reductions in body weight, total cholesterol, and concentrations of triglycerides, glucose, insulin, interleukin 6, and tumor necrosis factor-α as well as with improvements in insulin sensitivity. Human data support the findings of animal studies and demonstrate decreased body weight (though not consistently), lower concentrations of triglycerides, glucose, and low-density lipoprotein cholesterol, and increased concentrations of high-density lipoprotein cholesterol. These preliminary findings show promise for the use of TRF in modulating a variety of metabolic disease risk factors.

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“…For example, when rats on a shift work protocol are forced to work during the day, but are restricted to eating only during the night, excess weight gain, usually gained from abnormally timed feeding, is prevented, thus supporting a role for feeding time as an important factor in circadian disruption and metabolism [49]. …”

Section: Shifting Food: the Cue For The Food Entrainable Oscillatomentioning

confidence: 99%

Circadian disruption and metabolic disease: Findings from animal models

Arble

Ramsey

Bass

et al. 2010

Best Practice & Research Clinical Endocrinology & Metab

160

112

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Social opportunities and work demands have caused humans to become increasingly active during the late evening hours, leading to a shift from the predominantly diurnal lifestyle of our ancestors to a more nocturnal one. This voluntarily decision to stay awake long into the evening hours leads to circadian disruption at the system, tissue, and cellular levels. These derangements are in turn associated with clinical impairments in metabolic processes and physiology. The use of animal models for circadian disruption provides an important opportunity to determine mechanisms by which disorganization in the circadian system can lead to metabolic dysfunction in response to genetic, environmental, and behavioral perturbations. Here we review recent key animal studies involving circadian disruption and discuss the possible translational implications of these studies for human health and particularly for the development of metabolic disease.

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Food Intake during the Normal Activity Phase Prevents Obesity and Circadian Desynchrony in a Rat Model of Night Work

Cited by 35 publications

References 0 publications

Unaltered Instrumental Learning and Attenuated Body-Weight Gain in Rats During Non-rotating Simulated Shiftwork

Unaltered Instrumental Learning and Attenuated Body-Weight Gain in Rats During Non-rotating Simulated Shiftwork

Time-restricted feeding and risk of metabolic disease: a review of human and animal studies

Circadian disruption and metabolic disease: Findings from animal models

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