Food Hypersensitivity in Atopic Dermatitis During Infancy: Skin Prick Testing for Whom?

Emeksiz, Zeynep Şengül; Cavkaytar, Özlem; Aksoy, İlknur; Daller, Yıldız; Soyer, Özge

doi:10.21911/aai.16

Cited by 3 publications

(2 citation statements)

References 18 publications

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“…In a study examining 110 AD patients younger than 1 year old, serum total IgE and serum eosinophil levels were found to be higher in the food sensitive group, and it was reported that the serum total IgE and serum eosinophil level elevations provided a prediction for food sensitivity in patients with severe AD. [ 40 ] In our study, on the contrary, no statistically significant correlation was found between the severity of AD, serum total IgE level, percentage of eosinophils, and food sensitivity. Ciğerci Günaydın et al [ 22 ] reported in their study that there was no difference between food sensitivity and total serum IgE and serum eosinophil levels, similar to our results.…”

Section: Discussioncontrasting

confidence: 86%

Food Sensitivity in Children Diagnosed with Atopic Dermatitis in The First 2 Years: How Many of These Patients Are Truly Allergic?

Sipahi Cimen

2023

Sisli Etfal

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Objectives In this study, it was aimed to examine food sensitivity in patients with atopic dermatitis (AD) and to investigate the frequency of food allergy in patients with food sensitivity. Methods Patients aged 0–2 years who were followed up with the diagnosis of AD were included in the study. The characteristics of demographic and clinical and laboratory findings of the patients were recorded retrospectively. Patients were classified as mild, moderate, and severe using the SCORing AD index according to the severity of AD. The presence of food sensitivity was evaluated by skin prick test and serum-specific immunoglobulin (Ig)E results. Food allergy was diagnosed by oral food challenge (OFC) test. Results Of the 72 patients included in the study, 62.5% (n=45) were male, and the mean age was 9±4.8 months. When the disease severity was evaluated, it was mild in 40 patients (55.6%); moderate/severe AD was present in 32 patients (44.4%). The frequency of moderate/severe AD was higher in patients who were younger (p=0.01), whose symptoms started in the first 6 months (p=0.03), who had a family history of allergic disease (p=0.001), who breastfed for <6 months (p=0.01), who had a higher median serum total IgE level, and a higher percentage of serum eosinophils (p=0.005 and p=0.01, respectively). Food sensitivity in 45.8% of patients; food allergy was detected in 41.7% of them. The most common sensitivities and allergies were eggs white/yolk and cow’s milk, respectively. The rate of food sensitivity was found to be higher in male gender (p=0.03) and breastfed patients (p=0.03), whereas it was similar in patients with mild and moderate/severe AD. Conclusion In the investigation of food sensitivity in patients with AD, it is important to evaluate other demographic and clinical characteristics such as gender and breastfeeding, apart from the severity of disease. The OFC test should be performed to confirm the food allergy in patients with food sensitivity before the recommendation of an elimination diet.

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Section: Discussioncontrasting

confidence: 86%

Food Sensitivity in Children Diagnosed with Atopic Dermatitis in The First 2 Years: How Many of These Patients Are Truly Allergic?

Sipahi Cimen

2023

Sisli Etfal

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“…In a study involving 110 infants with AD, it was found that 70% were male. 12 In our study, food allergy was found in 60.60% of patients with AD. In a study conducted in Korea, food allergy was found in 37.1% of infants with AD aged 0-5 months and in 38.5% of infants aged 6-11 months.…”

Section: Discussionsupporting

confidence: 47%

Food Allergy and Philagrine Mutation in Children with Atopic Dermatitis

Ayçin¹

2022

Eur J Ther

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Objective: To determine the frequency and type of food allergy in patients having atopic dermatitis and to show the presence of mutations genetically. Methods: Patients diagnosed as having atopic dermatitis according to the Hanifin Rajka criteria were evaluated retrospectively. Eosinophils, total immunoglobin E, milk-specific immunoglobulin E, egg-specific immunoglobulin E, wheat-specific immunoglobulin E, and filaggrin gene mutation results were recorded. Nutrient elimination was performed for 1 month in patients who were thought to have food allergy owing to skin prick test and milk-specific immunoglobulin E results. The diagnosis was confirmed through a food loading test for the patients who benefited from the elimination. Results: Of the 66 patients included in the study, 42 (63.63%) were male. Food allergies were detected in 40 patients (60.6%). According to the Scoring of Atopic Dermatitis index, 9 out of 16 patients aged 40 years and over had food allergy and 31 out of 50 patients aged under 40 years had food allergy. There was no significant difference between the groups (P = .56). All patients included in the study were examined for filaggrin. Only 1 patient with a Scoring of Atopic Dermatitis index below 40 and milk allergy was found to have p.R501 * and c.2282-2285delCAGT mutations. Conclusion: Atopic dermatitis food allergy was found to be 60.6%. The most common improvement was egg allergy and egg elimination. There was no difference between atopic dermatitis severity and food allergy and laboratory tests. Severe atopic dermatitis was found to be 24.2%.

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Evaluation of Food Sensitivity in Children With Atopic Dermatitis

Büyük Yaytokgil,

Vezir

2024

Kırıkkale Üniversitesi Tıp Fakültesi Dergisi

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Objective: Atopic dermatitis is considered an important risk factor for the development of food allergies. This retrospective study aimed to evaluate food sensitivity in pediatric patients with atopic dermatitis based on skin prick tests. Material and Methods: The study included children diagnosed with atopic dermatitis who underwent skin prick tests with food allergens at our hospital’s Pediatric Allergy Clinic between January 1, 2023 and January 31, 2024. Demographic data, atopic dermatitis onset age, severity, treatments, and co-existing atopic diseases (asthma, allergic rhinitis) were collected from medical records. Skin prick test results were evaluated retrospectively. Results: The study comprised 229 patients, predominantly male (64.2%) with a median age of 7 months (IQR:5-14). The median age at atopic dermatitis onset was 3 (IQR:2-6) months. Co-existing allergic diseases were present in 12 (5.2%) patients. Based on SCORing Atopic Dermatitis (SCORAD), atopic dermatitis severity was mild in 61.1%, moderate in 29.3%, and severe in 9.6% of patients. Food allergen sensitization was observed in 73 (31.9%) patients, predominantly to hen's egg (28.4%). Multiple food sensitivities occurred in 10% of patients (n=23). Patients with food sensitivityshowed earlier atopic dermatitis onset, higher total IgE and eosinophil counts, and more frequent moderate-severe atopic dermatitis (p500/ mm3 as risk factors for sensitization. Conclusion: Approximately one-third of pediatric atopic dermatitis patients exhibited sensitivity to at least one food allergen, most commonly hen’s egg. Early atopic dermatitis onset, elevated eosinophils, and moderate-severe atopic dermatitis pose a higher risk for sensitization. Hence, mitigating unnecessary elimination diets and prompt referral of these patients to pediatric allergy clinics is crucial.

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Food Hypersensitivity in Atopic Dermatitis During Infancy: Skin Prick Testing for Whom?

Cited by 3 publications

References 18 publications

Food Sensitivity in Children Diagnosed with Atopic Dermatitis in The First 2 Years: How Many of These Patients Are Truly Allergic?

Food Sensitivity in Children Diagnosed with Atopic Dermatitis in The First 2 Years: How Many of These Patients Are Truly Allergic?

Food Allergy and Philagrine Mutation in Children with Atopic Dermatitis

Evaluation of Food Sensitivity in Children With Atopic Dermatitis

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