Food for thought: the ketogenic diet for epilepsy

Greener, Mark

doi:10.1002/pnp.329

Cited by 3 publications

(2 citation statements)

References 10 publications

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“…The classic ketogenic diet was introduced in 1921 to replace starvation in the treatment of epilepsy ( Greener, 2014 ). The ketogenic diet is high in fat with moderate levels of protein and low carbohydrate.…”

Section: Ketogenic Diet and Autism Spectrum Disordersmentioning

confidence: 99%

Diet in treatment of autism spectrum disorders

2023

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Altering the diet to treat disease dates to c. 400 BC when starvation was used to reduce seizures in persons with epilepsy. The current diversity of symptomology and mechanisms underlying autism spectrum disorders (ASDs) and a corresponding lack of disorder-specific effective treatments prompts an evaluation of diet as a therapeutic approach to improve symptoms of ASDs. In this review article, we summarize the main findings of nutritional studies in ASDs, with an emphasis on the most common monogenic cause of autism, Fragile X Syndrome (FXS), and the most studied dietary intervention, the ketogenic diet as well as other dietary interventions. We also discuss the gut microbiota in relation to pre- and probiotic therapies and provide insight into future directions that could aid in understanding the mechanism(s) underlying dietary efficacy.

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Section: Ketogenic Diet and Autism Spectrum Disordersmentioning

confidence: 99%

Diet in treatment of autism spectrum disorders

2023

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“…The new drugs are designed to address specific pathophysiologic defects such as seizure generation or spread where the old medicines are not useful any more. Other novel approaches to control epilepsy include electrical stimulation devices, such as vagus nerve stimulator (14)(15)(16), deep brain stimulation (DBS) (17,18) and dietary interventions (ketogenic diet) (19)(20)(21)(22). Despite the availability of all new and old AEDs, along with the arrival of new techniques, seizures are particularly challenging to treat.…”

Section: Introductionmentioning

confidence: 99%

An overview of structurally diversified anticonvulsant agents

Alotaibi

2019

Acta Pharmaceutica

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There are several limited approaches to treat epilepsy in hospitals, for example, using medicines, surgery, electrical stimulation and dietary interventions. Despite the availability of all these new and old approaches, seizure is particularly difficult to manage. The quest for new antiepileptic molecules with more specificity and less CNS toxicity continues for medicinal chemists until a new and ideal drug arrives. This review covers new antiseizure molecules of different chemical classes, the exact mode of action of which is still unidentified. Newer agents include sulfonamides, thiadiazoles, semi- and thiosemicarbazones, pyrrolidine-2,5-diones, imidazoles, benzothiazoles and amino acid deriva tives. These new chemical entities can be useful for the design and development of forthcoming antiseizure agents.

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Understanding drug-resistant epilepsy

Greener¹

2021

British Journal of Neuroscience Nursing

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Food for thought: the ketogenic diet for epilepsy

Cited by 3 publications

References 10 publications

Diet in treatment of autism spectrum disorders

Diet in treatment of autism spectrum disorders

An overview of structurally diversified anticonvulsant agents

Understanding drug-resistant epilepsy

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