Food entrainment: major and recent findings

Carneiro, Breno Tercio Santos; Araújo, John Fontenele

doi:10.3389/fnbeh.2012.00083

Cited by 45 publications

(30 citation statements)

References 76 publications

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“…In contrast, the locomotor activity of the Wistar rats was redistributed due to RF into only two bouts, one related to food presence and the second remaining synchronized with the external LD cycle. A similar effect of RF on the locomotor activity of Wistar rats has been observed previously elsewhere (e.g., see [40]). The results suggest that whereas in Wistar rats the behavioral activity is entrained by RF as well as by the external LD conditions, in SHR, RF dominates the entraining cue.…”

Section: Discussionsupporting

confidence: 87%

Increased Sensitivity of the Circadian System to Temporal Changes in the Feeding Regime of Spontaneously Hypertensive Rats - A Potential Role for Bmal2 in the Liver

et al. 2013

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The mammalian timekeeping system generates circadian oscillations that rhythmically drive various functions in the body, including metabolic processes. In the liver, circadian clocks may respond both to actual feeding conditions and to the metabolic state. The temporal restriction of food availability to improper times of day (restricted feeding, RF) leads to the development of food anticipatory activity (FAA) and resets the hepatic clock accordingly. The aim of this study was to assess this response in a rat strain exhibiting complex pathophysiological symptoms involving spontaneous hypertension, an abnormal metabolic state and changes in the circadian system, i.e., in spontaneously hypertensive rats (SHR). The results revealed that SHR were more sensitive to RF compared with control rats, developing earlier and more pronounced FAA. Whereas in control rats, the RF only redistributed the activity profiles into two bouts (one corresponding to FAA and the other corresponding to the dark phase), in SHR the RF completely phase-advanced the locomotor activity according to the time of food presentation. The higher behavioral sensitivity to RF was correlated with larger phase advances of the hepatic clock in response to RF in SHR. Moreover, in contrast to the controls, RF did not suppress the amplitude of the hepatic clock oscillation in SHR. In the colon, no significant differences in response to RF between the two rat strains were detected. The results suggested the possible involvement of the Bmal2 gene in the higher sensitivity of the hepatic clock to RF in SHR because, in contrast to the Wistar rats, the rhythm of Bmal2 expression was advanced similarly to that of Bmal1 under RF. Altogether, the data demonstrate a higher behavioral and circadian responsiveness to RF in the rat strain with a cardiovascular and metabolic pathology and suggest a likely functional role for the Bmal2 gene within the circadian clock.

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Section: Discussionsupporting

confidence: 87%

Increased Sensitivity of the Circadian System to Temporal Changes in the Feeding Regime of Spontaneously Hypertensive Rats - A Potential Role for Bmal2 in the Liver

et al. 2013

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“…Most species acquire food anticipatory behavior when food is restricted to a daily temporal window (reviewed in (Aragona, Curtis, Davidson, Wang, & Stephan, 2002; Carneiro & Araujo, 2012; Mistlberger, 2011; Schibler, Ripperger, & Brown, 2003)). Importantly, these food seeking oscillations persists even in SCN-ablated animals (Stephan, Swann, & Sisk, 1979), as does water seeking (Mistlberger, 1993).…”

Section: Introductionmentioning

confidence: 99%

A time to remember: The role of circadian clocks in learning and memory.

Smarr¹,

Jennings²,

Driscoll³

et al. 2014

Behavioral Neuroscience

144

131

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The circadian system has pronounced influence on learning and memory, manifesting as marked changes in memory acquisition and recall across the day. From a mechanistic level, the majority of studies have investigated mammalian hippocampal dependent learning and memory, as this system is highly tractable. The hippocampus plays a major role in learning and memory and has the potential to integrate circadian information in many ways, including information from local, independent oscillators, and through circadian modulation of neurogenesis, synaptic remodeling, intracellular cascades, and epigenetic regulation of gene expression. These local processes are combined with input from other oscillatory systems to synergistically augment hippocampal rhythmic function. This overview presents an account of the current state of knowledge on circadian interactions with learning and memory circuitry and provides a framework for those interested in further exploring these interactions.

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“…Bolles and de Lorge (5) were the first to demonstrate endogenous circadian control of food anticipation (reviewed in Ref. 10). The oscillators linking such rhythms to feeding schedule are referred to as food-entrainable oscillators (FEO; Ref.…”

Section: Discussionmentioning

confidence: 99%

Leptin-sensitive neurons in the arcuate nucleus integrate activity and temperature circadian rhythms and anticipatory responses to food restriction

Wiater

Dinh

et al. 2013

American Journal of Physiology-Regulatory, Integrative and Comp

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Wiater MF, Li A-J, Dinh TT, Jansen HT, Ritter S. Leptin-sensitive neurons in the arcuate nucleus integrate activity and temperature circadian rhythms and anticipatory responses to food restriction. Am J Physiol Regul Integr Comp Physiol 305: R949 -R960, 2013. First published August 28, 2013 doi:10.1152/ajpregu.00032.2013.-Previously, we investigated the role of neuropeptide Y and leptin-sensitive networks in the mediobasal hypothalamus in sleep and feeding and found profound homeostatic and circadian deficits with an intact suprachiasmatic nucleus. We propose that the arcuate nuclei (Arc) are required for the integration of homeostatic circadian systems, including temperature and activity. We tested this hypothesis using saporin toxin conjugated to leptin (Lep-SAP) injected into Arc in rats. Lep-SAP rats became obese and hyperphagic and progressed through a dynamic phase to a static phase of growth. Circadian rhythms were examined over 49 days during the static phase. Rats were maintained on a 12:12-h light-dark (LD) schedule for 13 days and, thereafter, maintained in continuous dark (DD). After the first 13 days of DD, food was restricted to 4 h/day for 10 days. We found that the activity of Lep-SAP rats was arrhythmic in DD, but that food anticipatory activity was, nevertheless, entrainable to the restricted feeding schedule, and the entrained rhythm persisted during the subsequent 3-day fast in DD. Thus, for activity, the circuitry for the light-entrainable oscillator, but not for the food-entrainable oscillator, was disabled by the Arc lesion. In contrast, temperature remained rhythmic in DD in the Lep-SAP rats and did not entrain to restricted feeding. We conclude that the leptin-sensitive network that includes the Arc is required for entrainment of activity by photic cues and entrainment of temperature by food, but is not required for entrainment of activity by food or temperature by photic cues.feeding; obesity; hypothalamus; saporin; BMAL-1; glucose THE ARCUATE NUCLEUS (ARC) of the hypothalamus is a key site for the regulation of feeding, adiposity, and metabolism, which is dependent on the adipose tissue-derived hormone leptin (19,56). Receptors for leptin occur densely in the Arc and are often coexpressed with neuropeptide Y (NPY) (3, 52). The mediobasal hypothalamus, including the Arc, contributes to the hypothalamic control of circadian rhythms, including feeding and rest/activity (22,49,59,28). Obese Zucker rats lacking leptin receptors maintain modified light-entrained temperature and locomotor rhythms and enhanced food anticipatory activity (41, 37). Diet-induced obesity decreases food anticipatory activity (43), suggesting that the Arc leptin/NPY circuits are critical to the anticipation of scheduled food availability, inhibiting activity when leptin levels are enhanced by obesity and facilitating activity when leptin signaling is absent (38). Similar observations in obese lesioned rats for core body temperature (Tb), activity, and food anticipation have been reported for rats with electrolytic...

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Food entrainment: major and recent findings

Cited by 45 publications

References 76 publications

Increased Sensitivity of the Circadian System to Temporal Changes in the Feeding Regime of Spontaneously Hypertensive Rats - A Potential Role for Bmal2 in the Liver

Increased Sensitivity of the Circadian System to Temporal Changes in the Feeding Regime of Spontaneously Hypertensive Rats - A Potential Role for Bmal2 in the Liver

A time to remember: The role of circadian clocks in learning and memory.

Leptin-sensitive neurons in the arcuate nucleus integrate activity and temperature circadian rhythms and anticipatory responses to food restriction

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