Food emulsifier polysorbate 80 promotes the intestinal absorption of mono-2-ethylhexyl phthalate by disturbing intestinal barrier

Zhu, Yuting; Yuan, Yi-Zhen; Feng, Qiu-Ping; Hu, Ming‐Liang; Li, Wenjie; Wu, Xue-Ru; Xiang, Su-Yun; Yu, Shu‐Qin

doi:10.1016/j.taap.2021.115411

Cited by 20 publications

(11 citation statements)

References 49 publications

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“…[ 43 , 44 ] In addition, DTX micelles have good water solubility, which eliminates the need for Tween 80 to increase the dissolution of DTX and thus reduces damage to the intestinal barrier. [ 45 ] This may be the reason that the DTX micelles caused less intestinal barrier damage than free DTX.…”

Section: Resultsmentioning

confidence: 99%

Effects of Docetaxel Injection and Docetaxel Micelles on the Intestinal Barrier and Intestinal Microbiota

Liu

Xiao

et al. 2021

Advanced Science

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Increasing evidence has suggested that chemotherapeutics affect the integrity of the intestinal barrier and alter the intestinal microbiota, thus limiting the therapeutic outcomes of cancer chemotherapy. Docetaxel (DTX) is used for breast cancer treatment and has gastrointestinal side effects, but the influence of DTX formulations on the intestinal barrier and intestinal microbiota remains unknown. Therefore, in this work, the influence of DTX injection (free DTX, commercial formulation) and DTX/methoxy poly(ethylene glycol)-block-poly(D,L-lactide) (mPEG-PDLLA) (DTX micelles, nanoformulation) on the integrity of the intestinal barrier and the intestinal microbiota is investigated. It is found that the free DTX causes significantly greater intestinal barrier damage than the DTX micelles. The diversity of the intestinal microbiota, and the relative abundance of Akkermansia muciniphila and Ruminococcus gnavus in the DTX micelle-treated group is significantly higher than that in the free DTX-treated group. Moreover, the tumor growth rate is elevated in antibiotic mixture-pretreated mice, demonstrating that the diversity and composition of the intestinal microbiota may be associated with tumor progression. This work demonstrates that different formulations of chemotherapeutics have different effects on the integrity of the intestinal barrier and the intestinal microbiota.

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Section: Resultsmentioning

confidence: 99%

Effects of Docetaxel Injection and Docetaxel Micelles on the Intestinal Barrier and Intestinal Microbiota

Liu

Xiao

et al. 2021

Advanced Science

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“…Polysorbate 80 promotes the intestinal absorption and bioavailability of di-2-ethylhexyl phthalate (DEHP) and its primary toxic metabolite mono-2-ethylhexyl phthalate (MEHP) by disrupting the intestinal barrier through gut microbiota modifications. Alterations in the intestinal barrier after P80 administration in rats were studied with 5-aminofluorescein-MEHP (MEHP-AF), a small fluorescent molecule used as a tracker of the toxic metabolite mono-2-ethylhexyl phthalate [ 73 ]. If we consider that processed foods are often stored in packaging containing the molecules mentioned above, we realize the impact that processed foods could have on our health.…”

Section: Relationship Between Emulsifiers and Metabolic Syndrome Thro...mentioning

confidence: 99%

Food Emulsifiers and Metabolic Syndrome: The Role of the Gut Microbiota

Siena

Raoul

Costantini

et al. 2022

Foods

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The use of emulsifiers in processed foods and the rapid epidemic development of metabolic syndrome in Western countries over the past 20 years have generated growing interest. Evidence for the role of emulsifiers in metabolic syndrome through gut microbiota has not been clearly established, thus making it challenging for clinical nutritionists and dietitians to make evidence-based associations between the nature and the quantity of emulsifiers and metabolic disorders. This narrative review summarizes the highest quality clinical evidence currently available about the impact of food emulsifiers on gut microbiota composition and functions and the potential development of metabolic syndrome. The state-of-the-art of the different common emulsifiers is performed, highlighting where they are present in daily foods and their roles. Recent findings of in vitro, in vivo, and human studies assessing the effect of different emulsifiers on gut microbiota have been recently published. There is some progress in understanding how some food emulsifiers could contribute to developing metabolic diseases through gut microbiota alterations while others could have prebiotic effects. However, there are still many unanswered questions regarding daily consumption amounts and the synergic effects between emulsifiers’ intake and responses by the microbial signatures of each individual.

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“…Emulsifiers, also called surfactants, are amphipathic molecules, having both hydrophobic and hydrophilic regions that allow these molecules to interact with both oily and aqueous substances, and are commonly used in processed foods. There is accumulating evidence on the toxicity of emulsifiers as they increase TJ permeability [76,77]. The detrimental impact of the widespread use of emulsifiers in processed food is now being widely studied [78,79].…”

Section: Food Emulsifiers and Dietary Factorsmentioning

confidence: 99%

Epithelial barrier hypothesis and the development of allergic and autoimmune diseases

Yazıcı¹,

Öğülür²,

Küçükkase³

et al. 2022

Allergo J

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The "epithelial barrier hypothesis" proposes that genetic predisposition to epithelial barrier damage, exposure to various epithelial barrier-damaging agents and chronic periepithelial inflammation are responsible for the development of allergic and autoimmune diseases. Particularly, the introduction of more than 200,000 new chemicals to our daily lives since the 1960s has played a major role in the pandemic increase of these diseases. The epithelial barrier constitutes the first line of physical, chemical, and immuno-

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Food emulsifier polysorbate 80 promotes the intestinal absorption of mono-2-ethylhexyl phthalate by disturbing intestinal barrier

Cited by 20 publications

References 49 publications

Effects of Docetaxel Injection and Docetaxel Micelles on the Intestinal Barrier and Intestinal Microbiota

Effects of Docetaxel Injection and Docetaxel Micelles on the Intestinal Barrier and Intestinal Microbiota

Food Emulsifiers and Metabolic Syndrome: The Role of the Gut Microbiota

Epithelial barrier hypothesis and the development of allergic and autoimmune diseases

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