Food-drug interaction: Anabolic steroids aggravate hepatic lipotoxicity and nonalcoholic fatty liver disease induced by trans fatty acids

Santos, Jamili D.B.; Mendonça, Andréa A.S.; Sousa, Rafaela C.; Silva, Thaiany G.S.; Bigonha, Solange Mara; Santos, Eliziária Cardoso dos; Gonçalves, Reggiani Vilela; Novaes, Rômulo Dias

doi:10.1016/j.fct.2018.04.056

Cited by 28 publications

(11 citation statements)

References 67 publications

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“…In several animal studies, TFA has been verified to simultaneously induce inflammatory damage in the liver and alteration of the abovementioned factors. A diet rich in TFA can provoke hepatic oxidative stress through an increase in ROS production, a decrease in antioxidant enzymes activity in NAFLD [ 109 , 110 ]. In our study, after treating with TFA-rich diet, the elevated expression of OPN was observed both in Ppara -deficient mice and HCVcpTg mice [ 20 , 111 ].…”

Section: Role Of Tfa In the Progression Of Fibrosismentioning

confidence: 99%

Impact of Dietary Fat on the Progression of Liver Fibrosis: Lessons from Animal and Cell Studies

Jia

Kimura

2021

IJMS

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Previous studies have revealed that a high-fat diet is one of the key contributors to the progression of liver fibrosis, and increasing studies are devoted to analyzing the different influences of diverse fat sources on the progression of non-alcoholic steatohepatitis. When we treated three types of isocaloric diets that are rich in cholesterol, saturated fatty acid (SFA) and trans fatty acid (TFA) with hepatitis C virus core gene transgenic mice that spontaneously developed hepatic steatosis without apparent fibrosis, TFA and cholesterol-rich diet, but not SFA-rich diet, displayed distinct hepatic fibrosis. This review summarizes the recent advances in animal and cell studies regarding the effects of these three types of fat on liver fibrogenesis.

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Section: Role Of Tfa In the Progression Of Fibrosismentioning

confidence: 99%

Impact of Dietary Fat on the Progression of Liver Fibrosis: Lessons from Animal and Cell Studies

Jia

Kimura

2021

IJMS

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“…39 The exact mechanism remains undetermined; plausibly, it may be due to inhibition of fatty acid oxidation or due to increased synthesis of lipids. 40 We found the prevalence of glucocorticoid-induced NAFLD to be 7.7%. Out of these, one showed features of advanced fibrosis.…”

Section: Drug-induced Nafldmentioning

confidence: 69%

Primary Versus Secondary NAFLD: Perspective on Advanced Fibrosis

Shetty

Amarapurkar

Shukla³

2021

Journal of Clinical and Experimental Hepatology

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Background: The presence of macrovesicular steatosis on liver biopsy is the commonest histopathological finding. Nonalcoholic fatty liver disease (NAFLD) is the presence of $5% macrovesicular steatosis without significant alcohol use. It is subdivided into primary and secondary NAFLD; information on their differences is limited. Aim: To determine the histopathological differences between primary and secondary NAFLD and establish whether the prevalence of advanced fibrosis varies between the two types. Methodology: Three years of retrospective study of 90 liver biopsies with $5% macrovesicular steatosis. Age, gender, clinical history, serum transaminase levels were noted. The biopsy was reviewed for steatosis, inflammation, and fibrosis. Differences between primary and secondary NAFLD for age, gender, AST/ALT ratio, histopathological features were determined. Descriptive statistical analysis, 2-tailed Student's t test, Chi-square test, Fisher's exact test were used, where p < 0.05 was considered significant. Result: Primary and secondary NAFLD were 42 (46.7%) and 48 (53.3%), respectively. Inflammation was noted in 50 (55.5%) and fibrosis in 31 (34.4%). The prevalence of advanced fibrosis was 24.4%. Primary and secondary NAFLD differed significantly on ballooning degeneration, Mallory Denk bodies (MDBs), glycogenated nuclei, and fibrosis stage (p < 0.05). There were no significant differences among AST/ALT ratio, steatosis, and inflammation grade. Conclusion: Primary NAFLD is a more severe type of liver disease. On histopathology, ballooning degeneration, MDBs, glycogenated nuclei, and advanced fibrosis was more prevalent in primary than secondary NAFLD.

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“…Previous studies have demonstrated that in ammation 58 , increased blood AST levels 59 , and oxidative stress 56 are closely related to NAFLD's occurrence. Indeed, the direct disturbance effect of TFA on liver function is so that high-TFA diets have been used to induce NAFLD experimentally in some animal models [60][61][62] . Moreover, high-TFA diets might induce more severe liver steatosis than common high-fat diets, possibly through suppressing the enzyme adipose triglyceride lipase (ATGL) and subsequently promoting lipid accumulation in the liver 63 .…”

Section: Discussionmentioning

confidence: 99%

Metabolic parameters and gut microbiota composition of rats fed high-fat diets based on ruminant fat compared with hydrogenated vegetable fat

Lb¹,

Spa²,

Bessa³

et al. 2021

Preprint

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This study tested the hypothesis that naturally and industrially produced trans fatty acids (TFA) exert distinct effects on rats’ metabolic parameters. Wistar rat groups were fed the diets: CONT - without added fat; HVF − 20% hydrogenated vegetable fat (HVF); and RUM − 20% ruminant fat. Biochemical markers, cytokine levels, fatty acid (FA) composition of liver, heart and adipose tissue, liver histology and the gut microbial composition were also evaluated. Rats fed RUM presented lower deposition of adipose tissue and LDL and higher HDL and anti-inflammatory IL-10 than those fed CONT and HVF. Pro-inflammatory cytokines, malondialdehyde (MDA) and aspartate aminotransferase (AST) were higher in group HVF than CONT and RUM. In all types of tissue, the highest TFA levels were observed in rats fed HVF, which contributed to the development of fatty liver. The RUM diet led to higher concentrations of stearic acid and conjugated linoleic acid (CLA). The lower incorporation of TFA and distinct FA profile in the liver of rats fed RUM compared to HVF could be associated with protection hepatic. The microbial gut communities were significantly dissimilar among the groups. It is plausible that ruminant fat might reduce risk parameters involved in the development of cardiovascular disease.

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Food-drug interaction: Anabolic steroids aggravate hepatic lipotoxicity and nonalcoholic fatty liver disease induced by trans fatty acids

Cited by 28 publications

References 67 publications

Impact of Dietary Fat on the Progression of Liver Fibrosis: Lessons from Animal and Cell Studies

Impact of Dietary Fat on the Progression of Liver Fibrosis: Lessons from Animal and Cell Studies

Primary Versus Secondary NAFLD: Perspective on Advanced Fibrosis

Metabolic parameters and gut microbiota composition of rats fed high-fat diets based on ruminant fat compared with hydrogenated vegetable fat

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