Food Deprivation, Body Weight Loss and Anxiety-Related Behavior in Rats

Dietze, Silke; Lees, Katarina R.; Fink, Heidrun; Brosda, Jan; Voigt, Jörg-Peter

doi:10.3390/ani6010004

Cited by 34 publications

(25 citation statements)

References 62 publications

(76 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…However, previous data suggest that exploratory behavior is separable from seeking food and acquiring information associated with environmental aspects (Pierre et al, 2001). In addition, food deprivation for up to 48 h seemed not to alter anxiety or depression behavior (Dietze et al, 2016; Hendriksen et al, 2015). Thus, the underlying mechanism and function of the influence of acute FR on locomotor activity require further assessment.…”

Section: Discussionmentioning

confidence: 99%

“…The decreased activity could not explain changes of the retention in the Y-maze, because the total number of arm visits showed no significant difference from the control. On the other hand, previous studies have found that food deprivation for 0-48 h had no effect on the distance traveled in an open field test (Dietze et al, 2016;Pierre et al, 2001). It was assumed that the duration of fasting positively correlates the response rate of animals (Moscarello et al, 2009).…”

Section: Weight Loss Indexmentioning

confidence: 95%

See 1 more Smart Citation

Food restriction affects Y‐maze spatial recognition memory in developing mice

Chen

et al. 2017

Intl J of Devlp Neuroscience

View full text Add to dashboard Cite

The ambiguous effects of food restriction (FR) on cognition in rodents have been mostly explored in the aged brain by a variety of paradigms, in which either rewards or punishments are involved. This study aims to examine the effects of chronic and acute FR with varying intensities on spatial recognition memory in developing mice. We have used a Y-maze task that is based on the innate tendency of rodents to explore novel environments. In chronic FR, mice had 70-30% chow of control for seven weeks. In acute FR, mice were food restricted for 12-48h before the tests. We found that chronic FR had no effect on the preference of mice for novelty in the Y-maze, but severe FR (50-30% of control) caused impairment on spatial recognition memory. The impairment significantly correlated with the slow weight growth induced by FR. Acute FR also did not affect the novelty preference of mice, but either improved or impaired the memory retention. These data suggest chronic FR impairs Y-maze spatial recognition memory in developing mice depending on FR intensity and individual tolerability of the FR. Moreover, acute FR exerts diverse effects on the memory, either positive or negative. Our findings have revealed new insights on the effects of FR on spatial recognition memory in developing animals.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Weight Loss Indexmentioning

confidence: 95%

Food restriction affects Y‐maze spatial recognition memory in developing mice

Chen

et al. 2017

Intl J of Devlp Neuroscience

View full text Add to dashboard Cite

show abstract

“…This suggests that astroglial plasticity is part of a process that adapts the olfactory signal to physiological fasting. Prolonged fasting is stressful, and fasting for 24 hr to 48 hr activates the HPA axis and increases blood corticosterone in rats, depending on strain and age (Dietze, Lees, Fink, Brosda, & Voigt, 2016;Rowland, 2007). Our 48 hrfasted rats lost 18% of their body weight, probably associated with activation of the HPA axis.…”

Section: Discussionmentioning

confidence: 99%

Fasting induces astroglial plasticity in the olfactory bulb glomeruli of rats

Daumas-Meyer

Champeil‐Potokar

Chaumontet

et al. 2017

Glia

View full text Add to dashboard Cite

The detection of food odors by the olfactory system, which plays a key role in regulating food intake and elaborating the hedonic value of food, is reciprocally influenced by the metabolic state. Fasting increases olfactory performance, notably by increasing the activity of olfactory bulb (OB) neurons. The glutamatergic synapses between olfactory sensory neurons and mitral cells in the OB glomeruli are regulated by astrocytes, periglomerular neurons, and centrifugal afferents. We compared the expansion of astroglial processes by quantifying GFAP-labeled areas in fed and fasted rats to see whether OB glomerular astrocytes are involved in the metabolic sensing and adaptation of the olfactory system. Glomerular astroglial spreading was much greater in all OB regions of rats fasted for 17 hr than in controls. Intra-peritoneal administration of the anorexigenic peptide PYY or glucose in 17 hr-fasted rats respectively decreased their food intake or restored their glycemia, and reversed the fasting-induced astroglial spreading. Direct application of the orexigenic peptides ghrelin or NPY to OB slices increased astroglial spreading, whereas PYY resulted in astroglial retraction, in agreement with the in vivo effects of fasting and satiety on glomerular astrocytes. Thus the morphological plasticity of OB glomerular astrocytes depends on the metabolic state of the rats and is influenced by peptides that regulate food intake. This plasticity may be part of the mechanism by which the olfactory system adapts to food intake.

show abstract

“…At complete starvation violations of metabolic processes are observed in rats: inhibition of anabolism and generalized increase in protein catabolism. This is clinically manifested by a symptomatic complex, characterized by abrupt weight loss, agitation, and then depression, decreased diuresis, negative nitrogen balance (Dietze et al 2016).…”

Section: Resultsmentioning

confidence: 99%

Experimental research of garden spinach extract as a potential anabolic medicinal product

Nykyforuk¹,

Фіра²,

Lykhatskyi³

et al. 2020

PHAR

View full text Add to dashboard Cite

Disorders of protein metabolism – one of the pathologies, the treatment of which is an urgent problem of modern medicine and pharmacy. The importance of the problem is stipulated due to the prevalence of diseases that are accompanied by a violation of protein metabolism in the body. Restoration of protein resources during such conditions requires adequate intake of structural components from the outside – proteins, amino acids and other biologically active substances-correctors of protein metabolism. In recent decades, much attention has been paid to the discoveries of anabolic agents of natural origin, especially from plants. We conducted research on the study of the anabolic and antioxidant properties of dry extract of spinach garden leaves on the model of food deprivation in rats. Established, that the dry extract at the dose of 100 mg/kg body weight of animals prevents the development of organic disorders of protein metabolism, oxidative stress, prevents a sharp decrease in body weight and slows down the generalized catabolism caused by starvation in rats. Under the influence of the extract on the model of food deprivation, the diuretic function of the kidneys is preserved at the physiological level.

show abstract

Food Deprivation, Body Weight Loss and Anxiety-Related Behavior in Rats

Cited by 34 publications

References 62 publications

Food restriction affects Y‐maze spatial recognition memory in developing mice

Food restriction affects Y‐maze spatial recognition memory in developing mice

Fasting induces astroglial plasticity in the olfactory bulb glomeruli of rats

Experimental research of garden spinach extract as a potential anabolic medicinal product

Contact Info

Product

Resources

About