Food constituents as a cause of variation of C-peptide excretion in the urine.

Takai, Keiko; Nonaka, Kyohei; Ichihara, K.; Tarui, Seiichiro

doi:10.1507/endocrj1954.31.291

Cited by 8 publications

(3 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the NIDDM subjects in our study, this figure was 14.8%. Takai et al (17) studied the reproducibility of the 24-h urinary excretion of C-peptide in 10 normal and 17 NIDDM subjects (17). The coefficient of variation of urinary C-peptide was 23.4% in the normal and 39.1% in the diabetic subjects.…”

Section: Resultsmentioning

confidence: 99%

Reproducibility of βCell Function Estimates in Non-Insulin-Dependent Diabetes Mellitus

Gjessing¹,

Damsgaard

Matzen³

et al. 1987

Diabetes Care

View full text Add to dashboard Cite

We evaluated the reproducibility of different estimates of endogenous insulin secretion in 30 patients with non-insulin-dependent diabetes mellitus (NIDDM). Fasting blood glucose concentration was similar on the 2 days of study. The coefficients of variation of fasting plasma C-peptide, plasma C-peptide 6 min after the injection of 1 mg i.v. glucagon, and the increment in plasma C-peptide after glucagon were 16.0, 14.8 and 24.1%, respectively. The coefficients of variation of the corresponding plasma insulin values were 19.2, 24.8, and 34.8%, respectively. The coefficient of variation of 24-h urinary C-peptide excretion was 22.1%. Because fasting plasma C-peptide correlated closely with plasma C-peptide 6 min after glucagon (test 1: r = .70, P less than .01; test 2: r = .76, P less than .01), it seems that these two values can be used equally well as assessment of beta-cell function in NIDDM. In conclusion, fasting plasma insulin, fasting plasma C-peptide, and plasma C-peptide 6 min after glucagon stimulation showed a similar and acceptable degree of reproducibility. Plasma insulin 6 min after glucagon and increments in plasma insulin and C-peptide, as well as urinary C-peptide, seem to be less reproducible.

show abstract

Section: Resultsmentioning

confidence: 99%

Reproducibility of βCell Function Estimates in Non-Insulin-Dependent Diabetes Mellitus

Gjessing¹,

Damsgaard

Matzen³

et al. 1987

Diabetes Care

View full text Add to dashboard Cite

show abstract

“…The reproducibilities of these two tests have not been evaluated in insulin dependent diabetic patients. Though they studied non-insulin dependent diabetic patients, Takai et al 18 ) found that the consecutive measurement of 24-h urinary C-peptide (ug/day) revealed a considerable day-to-day variation in 17 patients (the average coefficient of variation = 39.1%). They suggested that the variability could be ascribed to the change in diet, the effect of exercise, and the variable urinary clearance of C-peptide.…”

Section: Discussionmentioning

confidence: 99%

Twenty-Four Hour Urinary C-peptide and Fasting Plasma C-peptide as Indicators of Metabolic Control in 83 Insulin Dependent Diabetic Patients

Yoo

Hartling

Binder

1987

Korean J Intern Med

View full text Add to dashboard Cite

In order to evaluate the usefulness of 24-hour urinary C-peptide and fasting plasma C-peptide as metabolic index, C-peptide was measured in 24-hour urine and in fasting plasma of 83 insulin dependent diabetic patients. Using multiple linear regression, HbAlc was analyzed as a dependent variable versus independent variables such as daily insulin dose, fasting plasma C-peptide and 24-hour urinary C-peptide. Twentyfour hour urinary C-peptide was significantly correlated with fasting plasma C-peptide showed significant inverse correlations with the daily insulin dose. But neither 24-hour urinary C-peptide nor fasting plasma C-peptide was significantly correlated with HbAlc as a dependent variable. These results show that there was no difference of usefulness between 24-hour urinary C-peptide and fasting plasma C-peptide in relation to HbAlc and daily insulin dose in insulin dependent diabetic patients.

show abstract

“…Consumption of a meal including fat also permits the study of postmeal lipemia. Takai et al (34) and Hoogwerf et al (33) found that carbohydrate and protein but not fat led to additive acute increases in UCP. Clearly, studies with food as the stimulus to insulin secretion must address the need to standardize the mix of carbohydrate and protein to be used.…”

Section: Meal-stimulated Ucpmentioning

confidence: 99%

C-peptide Response to Meal Challenge in Nondiabetic and Diabetic Adults Living in Wadena, Minnesota

Jacobs

et al. 1992

Diabetes Care

View full text Add to dashboard Cite

The data suggest that two forms of NIDDM may exist, crudely distinguished by the clinical decision to use insulin to control blood glucose levels. The insulin-taking diabetic individuals may experience a greater likelihood of pancreatic failure, whereas non-insulin-taking diabetic individuals probably experience stable pancreatic function over the course of their disease. Longitudinal observation of the Wadena cohort will provide more insight into this possibility.

show abstract

Food constituents as a cause of variation of C-peptide excretion in the urine.

Abstract: Since C-peptide immunoreactivity

Cited by 8 publications

References 16 publications

Reproducibility of βCell Function Estimates in Non-Insulin-Dependent Diabetes Mellitus

Reproducibility of βCell Function Estimates in Non-Insulin-Dependent Diabetes Mellitus

Twenty-Four Hour Urinary C-peptide and Fasting Plasma C-peptide as Indicators of Metabolic Control in 83 Insulin Dependent Diabetic Patients

C-peptide Response to Meal Challenge in Nondiabetic and Diabetic Adults Living in Wadena, Minnesota

Contact Info

Product

Resources

About