Food components and environmental chemicals of inhibiting human placental aromatase

Wang, Yiyan; Pan, Peipei; Li, Xiaoheng; Zhu, Qiqi; Huang, Tongliang

doi:10.1016/j.fct.2019.03.043

Cited by 11 publications

(5 citation statements)

References 83 publications

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“…In GCs, synthesis of E2 is regulated by many factors, including CYP19A1, which is an important rate‐limiting enzyme. Some endocrine‐disrupting compounds in the environment downregulate expression of CYP19A1, which has been linked to female infertility (Wang, Pan, et al, 2019). Hence, CYP19A1 has become an important target for the prevention and treatment of estrogen‐dependent diseases.…”

Section: Discussionmentioning

confidence: 99%

The effects of natural products and bioactive ingredients of traditional Chinese medicine on apoptosis of ovarian granulosa cells

Zhong

Luo

Zhou

et al. 2022

J of Applied Toxicology

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Abnormal ovarian function is the main manifestation of female reproductive toxicity. Granulosa cells (GCs) play an important role in determining the fate of follicles and are the main effector cells of the female reproductive system. Excessive apoptosis of GCs leads to pathological folliculogenesis and further reproductive damage. However, drugs available for treatment of female reproductive toxicity are limited. Recent studies have confirmed that various natural products and bioactive ingredients of traditional Chinese medicine (TCM) can inhibit apoptosis of GCs and protect ovarian function. In this review, the mechanisms underlying the proapoptotic and antiapoptotic effects of natural products and bioactive ingredients of TCM on the proliferation, function, and apoptosis of GCs are summarized based on the findings of reports published over the past 10 years as reference for the treatment of female reproductive toxicity.

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Section: Discussionmentioning

confidence: 99%

The effects of natural products and bioactive ingredients of traditional Chinese medicine on apoptosis of ovarian granulosa cells

Zhong

Luo

Zhou

et al. 2022

J of Applied Toxicology

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“…Interestingly, the increased T level in the serum did not reflect the change of serum E2 level. The serum estradiol level depends on not only the biosynthesis in the testis and peripheral tissues such as fat tissue due to the catalysis of aromatase but also on the metabolism in the liver 31 . However, the exact mechanism remains unclear.…”

Section: Discussionmentioning

confidence: 99%

Tetramethyl bisphenol A stimulates proliferation but inhibits fetal Leydig cell function in male rats by targeting estrogen receptor α after in utero exposure

Meng

et al. 2022

Environmental Toxicology

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Tetramethyl bisphenol A (TMBPA) is a widely used flame retardant. TMBPA has been a toxic to Leydig cells in puberty, but it remains unclear whether TMBPA has a similar inhibitor effect on fetal Leydig cells (FLCs). This study reported morphological and functional alterations of FLCs in the testes of male offspring at birth after in utero exposure to TMBPA. Pregnant Sprague Dawley rats were dosed via continuous gavage of TMBPA (0, 10, 50, and 200 mg/kg/day) from gestational day 14 to 21. TMBPA markedly raised serum total testosterone level, testicular volume, and FLC number of male offspring at 200 mg/kg dose. The up‐regulation of Insl3, Star, and Cyp11a1 mRNAs was observed after 200 mg/kg TMBPA exposure. After normalization to the number of FLCs, TMBPA significantly reduced Lhcgr and Hsd3b1 expressions at 10 mg/kg, and Cyp17a1 at 200 mg/kg paralleling with their protein levels. TMBPA compromised the expression of Esr1, while increased the expression of Cdk2 and Cdk4 as well as their protein levels. TMBPA particularly increased the phosphorylation of AKT1 and AKT2 at 200 mg/kg. In conclusion, the present study suggests that TMBPA may promote FLC proliferation via ESR1‐CDK2/4‐AKT pathway, while inhibits the function of FLCs by reducing steroidogenic enzyme activity.

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“…During pregnancy, fetal- and maternal-originated DHEAS enters the placenta, where it is metabolized into androstenedione and testosterone, which are further catalysed into estradiol and estrone by placental aromatase enzyme (CYP19A1) [ 14 ]. This potent aromatase eliminates androgen buildup in the maternal circulation and facilitates downstream placental production of estrogens [ 15 , 16 ]. In our case, both testosterone and DHEAS are secreted by SLCT and serve as the main substrates of the extremely high serum estradiol.…”

Section: Discussionmentioning

confidence: 99%

Severe intrahepatic cholestasis of pregnancy due to a Sertoli-Leydig cell tumour in a woman with polycystic ovary syndrome: a case report

Feng

et al. 2022

BMC Pregnancy Childbirth

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Background Intrahepatic cholestasis of pregnancy (ICP) is a common gestational complication characterized by pruritus and elevated bile acids, usually occurring in the third trimester when the serum estrogen and progesterone levels are highest. Hyperandrogenism during pregnancy is a pathological state that is mostly induced by polycystic ovary syndrome (PCOS) but rarely by concomitant androgen-secreting ovarian tumours. To date, no correlation has been drawn between ICP and hyperandrogenism. Case presentation Here, we present a rare case of early-onset severe ICP in a PCOS patient conceived via in vitro fertilization-embryo transfer, with worsening hirsutism and acne due to high levels of testosterone and dehydroepiandrosterone sulphate, both of which were produced by a fast-growing ovarian Sertoli–Leydig cell tumour. Her serum estradiol was also very high, which was speculated to be converted from the circulating androgens by the placenta. She had preterm premature rupture of membranes and delivered at 30 weeks, followed by a rapid remission of ICP as her serum estradiol dropped. However, the excessive androgens did not retreat until the large ovarian tumour was surgically removed. Conclusion This unusual case highlights the concurrence of original hyperandrogenism and subsequent hyperestrogenism during pregnancy and the resultant confounding manifestations. Obstetricians should be aware of the potential association between androgen excess and ICP via placental aromatization.

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Food components and environmental chemicals of inhibiting human placental aromatase

Cited by 11 publications

References 83 publications

The effects of natural products and bioactive ingredients of traditional Chinese medicine on apoptosis of ovarian granulosa cells

The effects of natural products and bioactive ingredients of traditional Chinese medicine on apoptosis of ovarian granulosa cells

Tetramethyl bisphenol A stimulates proliferation but inhibits fetal Leydig cell function in male rats by targeting estrogen receptor α after in utero exposure

Severe intrahepatic cholestasis of pregnancy due to a Sertoli-Leydig cell tumour in a woman with polycystic ovary syndrome: a case report

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