Food-anticipatory activity persists after olfactory bulb ablation in the rat

Davidson, Alec J.; Aragona, Brandon J.; Werner, R. Marshall; Schroeder, E. Todd; Smith, James C.; Stephan, Friedrich K.

doi:10.1016/s0031-9384(00)00417-0

Cited by 42 publications

(34 citation statements)

References 18 publications

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“…An example supporting this differential role of PER1 and PER2 is aPirC, the primary olfactory cortex. Ablation of the olfactory bulbs does not abolish food-anticipatory activity (Davidson et al, 2001), indicating that olfactory information is not essential for meal anticipation. It is probable though that it can reinforce feeding cues.…”

Section: Circadian Oscillations In the Forebrain Of Mice Fed With A Hmentioning

confidence: 91%

Forebrain oscillators ticking with different clock hands

Feillet

Mendoza

Albrecht

et al. 2008

Molecular and Cellular Neuroscience

133

113

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Clock proteins like PER1 and PER2 are expressed in the brain, but little is known about their functionality outside the main suprachiasmatic clock. Here we show that PER1 and PER2 were neither uniformly present nor identically phased in forebrain structures of mice fed ad libitum. Altered expression of the clock gene Cry1 was observed in respective Per1 or Per2 mutants. In response to hypocaloric feeding, PERs timing was not markedly affected in few forebrain structures (hippocampus). In most other forebrain oscillators, including those expressing only PER1 (e.g., dorsomedial hypothalamus), PER2 (e.g., paraventricular hypothalamus) or both (e.g., paraventricular thalamus), PER1 was up-regulated and PER2 largely phase-advanced. Cry1 expression was selectively modified in the forebrain of Per mutants challenged with hypocaloric feeding. Our results suggest that there is not one single cerebral clock, but a system of multiple brain oscillators ticking with different clock hands and differentially sensitive to nutritional cues.

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Section: Circadian Oscillations In the Forebrain Of Mice Fed With A Hmentioning

confidence: 91%

Forebrain oscillators ticking with different clock hands

Feillet

Mendoza

Albrecht

et al. 2008

Molecular and Cellular Neuroscience

133

113

View full text Add to dashboard Cite

show abstract

“…For example, a food entrainable (FEO) produces anticipatory behaviors when food availability is restricted daily, even when the SCN or the OB are ablated (Davidson et al, 2001;Stephan, 2002;Herzog and Muglia, 2006). Recent evidence has suggested the FEO may be within the dorsal medial hypothalamus (Gooley et al, 2006;Mieda et al, 2006; but see Landry et al, 2006).…”

Section: A Separable Circadian Timing Systemmentioning

confidence: 99%

A Circadian Clock in the Olfactory Bulb Controls Olfactory Responsivity

Granados‐Fuentes¹,

Tseng²,

Herzog³

2006

J. Neurosci.

142

127

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Recently, it has been shown that multiple mammalian cell types express daily rhythms in vitro. Although the suprachiasmatic nucleus (SCN) of the hypothalamus is known to regulate a wide range of circadian behaviors, the role for intrinsic rhythmicity in other tissues is unknown. We tested whether the main olfactory bulb (OB) of mice mediates daily changes in olfaction. We found circadian rhythms in cedar oil-induced c-Fos, a protein marker of cellular excitation, in the mitral and granular layers of the OB and in the piriform cortex (PC). These oscillations persisted in constant darkness with a fourfold change in amplitude and a peak ϳ4 h after the onset of daily locomotor activity. Electrolytic lesions of the SCN abolished circadian locomotor rhythms, but not odor-induced c-Fos rhythms in the OB or PC. Furthermore, removal of the OB abolished spontaneous circadian cycling of c-Fos in the PC, shortened the free-running period of locomotor rhythms, and accelerated re-entrainment after a 6 h advance and slowed re-entrainment after a 6 h delay in the light schedule. OB ablation or odorant altered the amplitude of c-Fos rhythms in the SCN and ablation of one OB abolished c-Fos rhythms in the ipsilateral PC, but not in the contralateral OB and PC. We conclude that the OB comprises a master circadian pacemaker, which enhances olfactory responsivity each night, drives rhythms in the PC, and interacts with the SCN to coordinate other daily behaviors.

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“…FAA is robust after a complete bilateral lesion of the suprachiasmatic nucleus (SCN) (5), indicating that it does not depend on the master clock driving circadian rhythms of behavioral activity under constant food availability. Thus was born the arduous search for the site of the postulated food-entrainable circadian clock underlying FAA (6)(7)(8)(9)(10)(11)(12)(13)(14), a clock that is privileged, like that of the SCN, to govern overt behavior, endowing it with particular importance.…”

mentioning

confidence: 99%

Daily rhythms of food-anticipatory behavioral activity do not require the known circadian clock

Storch

Weitz

2009

Proc. Natl. Acad. Sci. U.S.A.

211

209

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When food availability is restricted to a particular time each day, mammals exhibit food-anticipatory activity (FAA), a daily increase in locomotor activity preceding the presentation of food. Considerable historical evidence suggests that FAA is driven by a foodentrainable circadian clock distinct from the master clock of the suprachiasmatic nucleus. Multiple food-entrainable circadian clocks have been discovered in the brain and periphery, raising strong expectations that one or more underlie FAA. We report here that mutant mice lacking known circadian clock function in all tissues exhibit normal FAA both in a light-dark cycle and in constant darkness, regardless of whether the mutation disables the positive or negative limb of the clock feedback mechanism. FAA is thus independent of the known circadian clock. Our results indicate either that FAA is not the output of an oscillator or that it is the output of a circadian oscillator different from known circadian clocks.food-anticipatory activity ͉ mouse genetics W hen food availability is limited to a several-hour interval at a particular time each day, mammals quickly develop a new component of daily behavioral activity, a second period of arousal and increased locomotor activity that occurs shortly before the time of daily food presentation (1). This so-called food-anticipatory activity (FAA) is robust, stable over many daily cycles, and occurs even if the time of food availability lies within the light phase of the light-dark cycle, the resting period of the daily behavioral cycle for a nocturnal laboratory animal. Because feeding strategies are fundamental to survival, it is thought that FAA represents an evolutionary adaptation providing mammals with a highly flexible and efficient food-seeking program, one that is able, if necessary, to take advantage of food sources available at unusual times with respect to the animal's typical daily rest-activity cycle (2).The mechanisms underlying FAA have been under investigation for nearly 30 years. The accumulated evidence suggests that FAA is more likely to be generated by a food-entrainable circadian oscillator than by plausible alternatives, such as a passive hourglass mechanism or an associative memory process (1). In general, an unequivocal demonstration that a rhythmic process is driven by an oscillator requires observation of the persistence of the rhythm over multiple cycles following removal of the entraining stimulus. In the case of daily rhythms entrained to a light-dark cycle, testing for a postulated underlying circadian oscillator simply requires switching off the lights and monitoring the daily rhythms for persistence in constant darkness. For example, daily rhythms of locomotor activity, feeding, and drinking in a light-dark cycle persist indefinitely after a transition to constant darkness, and were thus long ago demonstrated to be driven by a light-entrainable circadian oscillator (3). In contrast, a compelling demonstration that FAA relies on a self-sustained, food-entrainable oscillator has been...

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Food-anticipatory activity persists after olfactory bulb ablation in the rat

Cited by 42 publications

References 18 publications

Forebrain oscillators ticking with different clock hands

Forebrain oscillators ticking with different clock hands

A Circadian Clock in the Olfactory Bulb Controls Olfactory Responsivity

Daily rhythms of food-anticipatory behavioral activity do not require the known circadian clock

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